Correlation between estrogen receptor β expression and the curative effect of endocrine therapy in breast cancer patients

Guo,Liying; Zhang,Yu; Zhang,Wei; Yilamu,Dilimina

doi:10.3892/etm.2014.1634

June-2014 Volume 7 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

June-2014 Volume 7 Issue 6

Full Size Image

Article

Correlation between estrogen receptor β expression and the curative effect of endocrine therapy in breast cancer patients

Authors:
- Liying Guo
- Yu Zhang
- Wei Zhang
- Dilimina Yilamu
View Affiliations / Copyright

Affiliations: Department of Breast Cancer, Digestive and Vascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Department of General Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China, Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
Pages: 1568-1572
|
Published online on: March 27, 2014

https://doi.org/10.3892/etm.2014.1634
Expand metrics +

Abstract

The aim of the present study was to investigate the association between the expression levels of estrogen receptor (ER)β and the curative effect of endocrine therapy in breast cancer patients. Cancer tissues were collected from 583 breast cancer patients between January 2000 and December 2010 and used for analysis. ERβ expression levels were determined using immunohistochemical staining. The Kaplan‑Meier method was used for survival analysis and the log‑rank test was conducted for difference analysis between survival times. In addition, Cox multivariate analysis was performed to analyze prognostic factors for breast cancer. In the immunohistochemical staining assay, a positive ERβ expression rate of <10% was defined as ERβ low expression, while >10% was defined as ERβ high expression. In patients expressing low levels of ERβ, the median tumor‑free survival time of the patients who received endocrine therapy was significantly higher compared with that of the patients who did not receive endocrine therapy. By contrast, in patients with high ERβ expression levels, there was no significant difference in the median tumor‑free survival time between the patients who received endocrine therapy and those who did not. In addition, compared with ERβ low expression patients, ERβ high expression patients had a significantly lower median tumor‑free survival time. Furthermore, ERβ expression, human epidermal growth factor receptor 2 expression, tumor size, lymph node metastasis, postoperative chemotherapy, radiotherapy and endocrine therapy were identified to be independent prognostic factors for breast cancer. Therefore, high ERβ expression in breast cancer indicates poor prognosis for endocrine therapy.

View Figures

View References

1	Kuiper GG, Enmark E, Pelto-Huikko M, et al: Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA. 93:5925–5930. 1996. View Article : Google Scholar : PubMed/NCBI
2	Yuan MQ, Ping GF and Nan KJ: Progress in research of estrogen receptor beta and primary liver cancer. Xian Dai Zhong Liu Yi Xue. 16:1826–1829. 2008.(In Chinese).
3	Yager JD and Davidson NE: Estrogen carcinogenesis in breast cancer. New Engl J Med. 354:270–282. 2006. View Article : Google Scholar : PubMed/NCBI
4	Esslimani-Sahla M, Simony-Lafontaine J, Kramar A, et al: Estrogen receptor beta (ERbeta) level not its ER beta cx variant helps to predict tamoxifen resistance in breast cancer. Clin Cancer Res. 10:5769–5776. 2004. View Article : Google Scholar : PubMed/NCBI
5	Hopp TA, Weiss HL, Parra IS, et al: Low levels of estrogen receptor beta protein predict resistance to tomoxifen therapy in breast cancer. Clin Cancer Res. 10:7490–7499. 2004. View Article : Google Scholar : PubMed/NCBI
6	Borgquist S, Holm C, Stendahl M, et al: Oestrogen receptors alpha and beta show different associations to clinicopathological parameters and their co-expression might predict a better response to endocrine treatment in breast cancer. J Clin Pathol. 61:197–203. 2008. View Article : Google Scholar
7	Lee H and Bai W: Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. Mol Cell Biol. 22:5835–5845. 2002. View Article : Google Scholar : PubMed/NCBI
8	Pettersson K and Gustafsson JA: Role of estrogen receptor beta in estrogen action. Annu Rev Physiol. 63:165–192. 2001. View Article : Google Scholar : PubMed/NCBI
9	Osborne CK and Schiff R: Estrogen-receptor biology: continuing progress and therapeutic implications. J Clin Oncol. 23:1616–1622. 2005. View Article : Google Scholar : PubMed/NCBI
10	Chung YL, Sheu ML, Yang SC, et al: Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her-2/neu and cell membrane estrogen receptor in breast cancer. Int J Cancer. 97:306–312. 2002. View Article : Google Scholar : PubMed/NCBI
11	Jensen EV, Cheng G, Palmieri C, et al: Estrogen receptors and proliferation markers in primary and recurrent breast cancer. Proc Natl Acad Sci USA. 98:15197–15202. 2001. View Article : Google Scholar : PubMed/NCBI
12	Razandi M, Pedram A and Levin ER: Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol Endocrinol. 14:1434–1447. 2000. View Article : Google Scholar : PubMed/NCBI
13	Sun H, Zhang J, Zhan ZG and Hao XS: Estrogen receptor β and related genes of its signaling pathway in development of different models of breast cancer. Zhonghua Shi Yan Wai Ke Za Zhi. 23:1422–1423. 2006.(In Chinese).
14	Yang SE and Li X: Expression and significance of ERβ and HER2 in breast cancer. Zhonghua Zhong Liu Za Zhi. 29:767–768. 2007.(In Chinese).

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation between estrogen receptor β expression and the curative effect of endocrine therapy in breast cancer patients

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles