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Article

Protective mechanism of Xuebijing injection against heat stroke in rats

  • Authors:
    • Jun Ji
    • Feihu Zhou
    • Hui Yue
    • Qing Song
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China
  • Pages: 1745-1751
    |
    Published online on: March 27, 2014
       https://doi.org/10.3892/etm.2014.1639
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Abstract

This study aimed to investigate the protective mechanism of Xuebijing injection (XBJ) against heat stroke (HS) in rats. Adult male Sprague Dawley rats were randomly divided into normal control (NC), normal saline‑treated HS (NS‑HS) and XBJ‑treated HS (XBJ‑HS) groups. At 47 and 57 min from the initiation of heat stress (42.5‑43.5˚C), the plasma levels of certain cytokines [interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α], biochemical indicators (creatinine, blood urea nitrogen, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) and coagulation indicators (activated partial thromboplastin time, prothrombin time, fibrinogen degradation products and D‑dimer) were detected, and microscopy of the liver tissue of the rats was conducted. At 47 and 57 min after the initiation of the heat stress, the levels of the cytokines, coagulation indicators and biochemical indicators in the NS‑HS group were significantly higher than those in the NC group (P<0.05). In the NS‑HS group, the levels of the aforementioned indices were significantly reduced compared with those in the NC and NS‑HS groups (P<0.05). In the NS‑HS group, serious liver cell congestion, nuclear swelling and central vein dilation were visible, along with the appearance of bubbles in the liver tissue. In the XBJ‑HS group, only a small number of congestive liver cells were identified, with occasional nuclear swelling but no bubbles, which was similar to the observations in the NC group. Early intervention treatment of HS with XBJ is able to reduce the systemic inflammatory response and coagulation activity and decrease the tissue ischemia and injury degree, thus extending the survival time of rats with HS.
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View References

1 

Bouchama A and Knochel JP: Heat stroke. N Engl J Med. 346:1978–1988. 2002. View Article : Google Scholar

2 

Leon LR and Helwig BG: Heat stroke: role of the systemic inflammatory response. J Appl Physiol (1985). 109:1980–1988. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Misset B, De Jonghe B, Bastuji-Garin S, et al: Mortality of patients with heatstroke admitted to intensive care units during the 2003 heat wave in France: a national multiple-center risk-factor study. Crit Care Med. 34:1087–1092. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Grogan H and Hopkins PM: Heat stroke: implications for critical care and anaesthesia. Br J Anaesth. 88:700–707. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Sun X, Lu D, Lv T and Mao Y: Effects of Xuebijing injection on serum protein level in early phase of septic rats. Zhongguo Zhong Yao Za Zhi. 35:223–225. 2010.In Chinese).;

6 

Hashim IA, Al-Zeer A, Al-Shohaib S, Al-Ahwal M and Shenkin A: Cytokine changes in patients with heatstroke during pilgrimage to Makkah. Mediators Inflamm. 6:135–139. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Huang H, Ji L, Song S, et al: Identification of the major constituents in Xuebijing injection by HPLC-ESI-MS. Phytochem Anal. 22:330–338. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Li YP, Qiao YJ, Wu ZX, et al: Effects of Xuebijing injection on thrombomodulin and endothelial cell protein C receptor in septic rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 19:365–368. 2007.(In Chinese).

9 

Wu CC, Liao MH, Chen SJ and Yen MH: Tetramethylpyradizine prevents inducible NO synthase expression and improves survival in rodent models of endotoxic shock. Naunyn Schmiedebergs Arch Pharmacol. 360:435–444. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Wan JM, Sit WH, Lee CL, Fu KH and Chan DK: Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury. Int Immunopharmacol. 6:750–758. 2006.PubMed/NCBI

11 

Wang H, Li W, Li J, et al: The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr. 136:360–365. 2006.PubMed/NCBI

12 

Li YP, Qiao YJ, Wu ZX, Yao YM, Yu Y and Wu Y: Effects of Xuebijing injection on high-mobility group box chromosomal protein 1 in septic rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 19:239–241. 2007.(In Chinese).

13 

Genfa L, Jiang Z, Hong Z, et al: The screening and isolation of an effective anti-endotoxin monomer from Radix Paeoniae Rubra using affinity biosensor technology. Int Immunopharmacol. 5:1007–1017. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Bouchama A, Parhar RS, el-Yazigi A, Sheth K and al-Sedairy S: Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke. J Appl Physiol (1985). 70:2640–2644. 1991.PubMed/NCBI

15 

Koch AE, Kunkel SL and Strieter RM: Cytokines in rheumatoid arthritis. J Investig Med. 43:28–38. 1995.PubMed/NCBI

16 

Chang DM: The role of cytokines in heatstroke. Immunol Invest. 22:553–561. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Lin MT, Liu HH and Yang YL: Involvement of interleukin-1 receptor mechanisms in development of arterial hypotension in rat heatstroke. Am J Physiol. 273:H2072–H2077. 1997.PubMed/NCBI

18 

Chiu WT, Kao TY and Lin MT: Increased survival in experimental rat heatstroke by continuous perfusion of interleukin-1 receptor antagonist. Neurosci Res. 24:159–163. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Roberts GT, Ghebeh H, Chishti MA, et al: Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model. Arterioscler Thromb Vasc Biol. 28:1130–1136. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Yao XQ, Zhang YH and Sun CH: Protective effects of Xuebijing effervescent tablet on vital organs in rats with toxic injury induced by endotoxin. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 24:357–359. 2012.(In Chinese).

21 

Lee JJ, Lin MT, Wang NL, Lin CL and Chang CK: Platonin, a cyanine photosensitizing dye, causes attenuation of circulatory shock, hypercoagulable state, and tissue ischemia during heat stroke. Shock. 24:577–582. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Jilma B and Derhaschnig U: Disseminated intravascular coagulation in heat stroke: a hot topic. Crit Care Med. 40:1370–1372. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Li CS, Jin M, Wu JY and Wu CJ: Effect of XueBiJing injection upon related proinflammatory factors and blood coagulation factors of vascular endothelial cells in severe septic patients. Zhonghua Yi Xue Za Zhi. 89:2744–2747. 2009.(In Chinese).

24 

Yin DM, Sun Q, Li YP, Dong N and Yao YM: Effects of Xuebijing injection on levels of tissue factor-bearing microparticles in peripheral blood in septic rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 21:564–565. 2009.(In Chinese).

25 

Sun X, Lu D, Lv T and Mao Y: Effects of Xuebijing injection on serum protein level in early phase of septic rats. Zhongguo Zhong Yao Za Zhi. 35:223–225. 2010.(In Chinese).

26 

Gao YL, Chai YF and Yao YM: Advancement in the research of mechanism of immune dysfunction in sepsis and the regulatory effects of Xuebijing injection. Zhonghua Shao Shang Za Zhi. 29:162–165. 2013.(In Chinese).

27 

Diller KR and Zhu L: Hypothermia therapy for brain injury. Annu Rev Biomed Eng. 11:135–162. 2009. View Article : Google Scholar

28 

Yenari MA and Hemmen TM: Therapeutic hypothermia for brain ischemia: where have we come and where do we go? Stroke. 41(10 Suppl): S72–S74. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Mattis JG and Yates AM: Heat stroke: helping patients keep their cool. Nurse Pract. 36:48–52. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ji J, Zhou F, Yue H and Song Q: Protective mechanism of Xuebijing injection against heat stroke in rats. Exp Ther Med 7: 1745-1751, 2014.
APA
Ji, J., Zhou, F., Yue, H., & Song, Q. (2014). Protective mechanism of Xuebijing injection against heat stroke in rats. Experimental and Therapeutic Medicine, 7, 1745-1751. https://doi.org/10.3892/etm.2014.1639
MLA
Ji, J., Zhou, F., Yue, H., Song, Q."Protective mechanism of Xuebijing injection against heat stroke in rats". Experimental and Therapeutic Medicine 7.6 (2014): 1745-1751.
Chicago
Ji, J., Zhou, F., Yue, H., Song, Q."Protective mechanism of Xuebijing injection against heat stroke in rats". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1745-1751. https://doi.org/10.3892/etm.2014.1639
Copy and paste a formatted citation
x
Spandidos Publications style
Ji J, Zhou F, Yue H and Song Q: Protective mechanism of Xuebijing injection against heat stroke in rats. Exp Ther Med 7: 1745-1751, 2014.
APA
Ji, J., Zhou, F., Yue, H., & Song, Q. (2014). Protective mechanism of Xuebijing injection against heat stroke in rats. Experimental and Therapeutic Medicine, 7, 1745-1751. https://doi.org/10.3892/etm.2014.1639
MLA
Ji, J., Zhou, F., Yue, H., Song, Q."Protective mechanism of Xuebijing injection against heat stroke in rats". Experimental and Therapeutic Medicine 7.6 (2014): 1745-1751.
Chicago
Ji, J., Zhou, F., Yue, H., Song, Q."Protective mechanism of Xuebijing injection against heat stroke in rats". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1745-1751. https://doi.org/10.3892/etm.2014.1639
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