Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients

Li,Biqiang; Lin,Wei; Lin,Nan; Dong,Xiaowen; Liu,Libin

doi:10.3892/etm.2014.1668

Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients

Authors:
- Biqiang Li
- Wei Lin
- Nan Lin
- Xiaowen Dong
- Libin Liu
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Affiliations: Department of Cadre Ward, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China, Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
Published online on: April 7, 2014 https://doi.org/10.3892/etm.2014.1668
Pages: 1671-1676

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Abstract

The present study aimed to explore the correlation between serum ferritin (SF) levels and the aggregation of metabolic disorders in non-diabetic elderly patients. A total of 2,600 patients were enrolled in the study. Various parameters, including blood pressure (BP), height, weight, lipid profiles, blood glucose (BG), body mass index (BMI), fasting insulin (FINS), serum uric acid (SUA), the urinary albumin/creatinine ratio (UACR) and SF levels were measured. A homeostatic model was used to evaluate insulin resistance (HOMA-IR) and β-cell function (HOMA-β). The quantitative insulin sensitivity check index (QUICKI) and disposition index (DI) were calculated. The QUICKI and DI decreased significantly and other parameters increased significantly when the number of metabolic disorders increased. Patients with high triglycerides (TG), high total cholesterol (TC), high SUA and obesity demonstrated higher SF levels than those with normal TG, normal TC, normal SUA and normal weight, respectively (P<0.01). Male patients with metabolic disorders (high TG, high TC, high BP, high SUA and obesity) had higher SF levels than female patients with the corresponding disorders (P<0.01). BG, FINS, BMI, TC, TG, SUA, HOMA-IR and HOMA-β were positively correlated with SF, while DI and QUICKI were negatively correlated with SF (P<0.01). Stepwise regression analysis showed that HOMA-IR, BMI, TC, TG and SUA were risk factors for elevated SF levels. In conclusion, the SF levels in non-diabetic, elderly individuals with metabolic disorders may be significantly related to the clustering of the metabolic disorders. Dyslipidemia, obesity, disorders of purine metabolism and insulin resistance may be important risk factors for higher SF levels in the elderly.

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1	Leiva E, Mujica V, Palomo I, Orrego R, Guzmán L, Núñez S, Moore-Carrasco R, Icaza G and Díaz N: High-sensitivity C-reactive protein and liver enzymes in individuals with metabolic syndrome in Talca, Chile. Exp Ther Med. 1:175–179. 2010.PubMed/NCBI
2	Jennings JR, Heim AF, Kuan DC, Gianaros PJ, Muldoon MF and Manuck SB: Use of total cerebral blood flow as an imaging biomarker of known cardiovascular risks. Stroke. 44:2480–2485. 2013. View Article : Google Scholar : PubMed/NCBI
3	Ginsberg H: Statins in cardiometabolic disease: what makes pitavastatin different? Cardiovasc Diabetol. 12(Suppl 1): S12013. View Article : Google Scholar : PubMed/NCBI
4	Haraguchi K, Uto H, Ohnou N, Tokunaga M, Tokunaga M, Utsunomiya A, Hanada S and Tsubouchi H: Serum prohepcidin levels are potential prognostic markers in patients with multiple myeloma. Exp Ther Med. 4:581–588. 2012.PubMed/NCBI
5	Wilson JG, Lindquist JH, Grambow SC, Crook ED and Maher JF: Potential role of increased iron stores in diabetes. Am J Med Sci. 325:332–339. 2003. View Article : Google Scholar : PubMed/NCBI
6	Wolff SP: Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br Med Bull. 49:642–652. 1993.PubMed/NCBI
7	George DK, Goldwurm S, MacDonald GA, Cowley LL, Walker NI, Ward PJ, Jazwinska EC and Powell LW: Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology. 114:311–318. 1998. View Article : Google Scholar : PubMed/NCBI
8	Williams MJ, Poulton R and Williams S: Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis. 165:179–184. 2002. View Article : Google Scholar : PubMed/NCBI
9	Piperno A, Trombini P, Gelosa M, Mauri V, Pecci V, Vergani A, Salvioni A, Mariani R and Mancia G: Increased serum ferritin is common in men with essential hypertension. J Hypertens. 20:1513–1518. 2002. View Article : Google Scholar : PubMed/NCBI
10	Sharifi F, Nasab NM and Zadeh HJ: Elevated serum ferritin concentrations in prediabetic subjects. Diab Vasc Dis Res. 5:15–18. 2008. View Article : Google Scholar : PubMed/NCBI
11	Mainous AG, Weinberg ED, Diaz VA, Johnson SP, Hulihan MM and Grant AM: Calcium channel blocker use and serum ferritin in adults with hypertension. Biometals. 25:563–568. 2012. View Article : Google Scholar : PubMed/NCBI
12	Deng X, Ma C-M and Liu B: The metabolism of healthy crowd in syndrome study on the correlation between diabetes and serum ferritin. Chin J Heal Manag. 6:271–272. 2012.
13	Bozzini C, Girelli D, Olivieri O, Martinelli N, Bassi A, De Matteis G, Tenuti I, Lotto V, Friso S, Pizzolo F and Corrocher R: Prevalance of body iron excess in the metabolic syndrome. Diabetes Care. 28:2061–2063. 2005. View Article : Google Scholar : PubMed/NCBI
14	Fernández-Real JM1, Peñarroja G, Castro A, García-Bragado F, Hernández-Aguado I and Ricart W: Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function. Diabetes. 51:1000–1004. 2002.PubMed/NCBI
15	Vari IS, Balkau B, Kettaneh A, Andre P, Tichet J, Fumeron F, Caces E, Marre M and Grandchamp B: Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population. Diabetes Care. 30:1795–1801. 2007. View Article : Google Scholar : PubMed/NCBI
16	Wärnberg J and Marcos A: Low grade inflammation and the metabolic syndrome in children and adolescents. Curr Opin Lipidol. 19:11–15. 2008.PubMed/NCBI
17	Lu Y, Shen ZH and Li HW: Effect of lifestyle intervention on metabolic syndrome artery in patients with early lesion detection index. Chinese Journal of Health Management. 6:45–49. 2012.(In Chinese).
18	El-Gebali HH, Tahir SA, Haider SS and El-Fakhri MM: Lipid peroxidative damage in the erythrocytes and elevation of serum LDL-cholesterol, apolipoprotein-B, ferritin and uric with age and in coronary heart disease patients. Saudi Med J. 21:184–189. 2000.PubMed/NCBI
19	Zhang J, Liu ZJ and Sun LP: Obesity children blood lipid, serum ferritin and fatty liver in simple. Chinese Journal of Child Health Care. 14:231–232. 2006.(In Chinese).
20	Piperno A, Trombini P, Gelosa M, Mauri V, Pecci V, Vergani A, Salvioni A, Mariani R and Mancia G: Increased serum ferritin is common in men with essential hypertension. J Hypertens. 20:1513–1518. 2002. View Article : Google Scholar : PubMed/NCBI