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Article

Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients

  • Authors:
    • Biqiang Li
    • Wei Lin
    • Nan Lin
    • Xiaowen Dong
    • Libin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cadre Ward, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China, Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
  • Pages: 1671-1676
    |
    Published online on: April 7, 2014
       https://doi.org/10.3892/etm.2014.1668
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Abstract

The present study aimed to explore the correlation between serum ferritin (SF) levels and the aggregation of metabolic disorders in non-diabetic elderly patients. A total of 2,600 patients were enrolled in the study. Various parameters, including blood pressure (BP), height, weight, lipid profiles, blood glucose (BG), body mass index (BMI), fasting insulin (FINS), serum uric acid (SUA), the urinary albumin/creatinine ratio (UACR) and SF levels were measured. A homeostatic model was used to evaluate insulin resistance (HOMA-IR) and β-cell function (HOMA-β). The quantitative insulin sensitivity check index (QUICKI) and disposition index (DI) were calculated. The QUICKI and DI decreased significantly and other parameters increased significantly when the number of metabolic disorders increased. Patients with high triglycerides (TG), high total cholesterol (TC), high SUA and obesity demonstrated higher SF levels than those with normal TG, normal TC, normal SUA and normal weight, respectively (P<0.01). Male patients with metabolic disorders (high TG, high TC, high BP, high SUA and obesity) had higher SF levels than female patients with the corresponding disorders (P<0.01). BG, FINS, BMI, TC, TG, SUA, HOMA-IR and HOMA-β were positively correlated with SF, while DI and QUICKI were negatively correlated with SF (P<0.01). Stepwise regression analysis showed that HOMA-IR, BMI, TC, TG and SUA were risk factors for elevated SF levels. In conclusion, the SF levels in non-diabetic, elderly individuals with metabolic disorders may be significantly related to the clustering of the metabolic disorders. Dyslipidemia, obesity, disorders of purine metabolism and insulin resistance may be important risk factors for higher SF levels in the elderly.
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Copy and paste a formatted citation
Spandidos Publications style
Li B, Lin W, Lin N, Dong X and Liu L: Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients. Exp Ther Med 7: 1671-1676, 2014.
APA
Li, B., Lin, W., Lin, N., Dong, X., & Liu, L. (2014). Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients. Experimental and Therapeutic Medicine, 7, 1671-1676. https://doi.org/10.3892/etm.2014.1668
MLA
Li, B., Lin, W., Lin, N., Dong, X., Liu, L."Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients". Experimental and Therapeutic Medicine 7.6 (2014): 1671-1676.
Chicago
Li, B., Lin, W., Lin, N., Dong, X., Liu, L."Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1671-1676. https://doi.org/10.3892/etm.2014.1668
Copy and paste a formatted citation
x
Spandidos Publications style
Li B, Lin W, Lin N, Dong X and Liu L: Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients. Exp Ther Med 7: 1671-1676, 2014.
APA
Li, B., Lin, W., Lin, N., Dong, X., & Liu, L. (2014). Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients. Experimental and Therapeutic Medicine, 7, 1671-1676. https://doi.org/10.3892/etm.2014.1668
MLA
Li, B., Lin, W., Lin, N., Dong, X., Liu, L."Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients". Experimental and Therapeutic Medicine 7.6 (2014): 1671-1676.
Chicago
Li, B., Lin, W., Lin, N., Dong, X., Liu, L."Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients". Experimental and Therapeutic Medicine 7, no. 6 (2014): 1671-1676. https://doi.org/10.3892/etm.2014.1668
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