Antiosteoporotic effects of Polycan in combination with calcium lactate‑gluconate in ovariectomized rats

  • Authors:
    • Jae‑Suk Choi
    • Joo Wan Kim
    • Ki Young Kim
    • Hyung‑Rae Cho
    • In Soon Choi
    • Sae Kwang Ku
  • View Affiliations

  • Published online on: June 20, 2014     https://doi.org/10.3892/etm.2014.1793
  • Pages: 957-967
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Abstract

The aim of the present study was to investigate the optimum composition of Polycan (β‑glucan complex) and calcium lactate‑gluconate (CaLG) that exhibited the most beneficial effects in ovariectomy (OVX)‑induced osteoporotic rats. Polycan and CaLG single formulas (100 mg/kg each), and three doses (50, 100 and 200 mg/kg) of three mixed formulas [polycan:CaLG (PCLG)=1:99, 5:95 and 10:90] were orally administered once a day for 84 days. The effects of the test materials were compared with those of a risedronate sodium‑treated group. OVX resulted in an increase in body weight, decreased bone formation, elevated serum osteocalcin levels and urine deoxypyridinoline/creatinine ratio, as well as decreased serum bone‑specific alkaline phosphatase levels, femur indices, bone mineral content, bone mineral density and failure load. However, these OVX‑induced osteoporotic changes markedly decreased following the administration of the test materials. Continuous oral treatment of Polycan or CaLG single formulas and the PCLG mixed formulas preserved bone mass and strength. The PCLG 10:90 mixed formula exhibited the most favorable synergistic antiosteoporotic effects in the OVX‑induced osteoporotic rats as compared with equal doses of the Polycan or CaLG single formulas.
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September-2014
Volume 8 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Choi JS, Kim JW, Kim KY, Cho HR, Choi IS and Ku SK: Antiosteoporotic effects of Polycan in combination with calcium lactate‑gluconate in ovariectomized rats. Exp Ther Med 8: 957-967, 2014
APA
Choi, J., Kim, J.W., Kim, K.Y., Cho, H., Choi, I.S., & Ku, S.K. (2014). Antiosteoporotic effects of Polycan in combination with calcium lactate‑gluconate in ovariectomized rats. Experimental and Therapeutic Medicine, 8, 957-967. https://doi.org/10.3892/etm.2014.1793
MLA
Choi, J., Kim, J. W., Kim, K. Y., Cho, H., Choi, I. S., Ku, S. K."Antiosteoporotic effects of Polycan in combination with calcium lactate‑gluconate in ovariectomized rats". Experimental and Therapeutic Medicine 8.3 (2014): 957-967.
Chicago
Choi, J., Kim, J. W., Kim, K. Y., Cho, H., Choi, I. S., Ku, S. K."Antiosteoporotic effects of Polycan in combination with calcium lactate‑gluconate in ovariectomized rats". Experimental and Therapeutic Medicine 8, no. 3 (2014): 957-967. https://doi.org/10.3892/etm.2014.1793