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Article

Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension

  • Authors:
    • Ying Zhang
    • Hong Wang
    • Huan-Wen Sun
    • Yu-Lan Chen
    • Ju‑Yan  Ouyang
    • Yu Wang
    • Ling Wang
    • Xiang-Yang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cadre Ward, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
  • Pages: 713-718
    |
    Published online on: June 23, 2014
       https://doi.org/10.3892/etm.2014.1799
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Abstract

The present study aimed to investigate the correlation between cystathionine β‑synthase (CBS) T833C polymorphisms and primary hypertension. A case‑control study was conducted by genotyping the representative variation in 545 hypertensive individuals (aged 49.23±7.56 years) and 500 normotensive individuals (aged 49.90±10.01 years). The T833C genetic polymorphisms of the CBS enzyme were detected in all subjects by amplification refractory mutation system polymerase chain reaction (PCR) analysis. The CBS T833C polymorphism was successfully genotyped in the general population with a sample size of 1,045 (545+500) individuals. The genotypic and allelic frequency distributions of the CBS T833C polymorphism were not significantly different between the hypertensive and normotensive groups (P>0.05). The CC genotype was significantly different (P<0.05) from the CT and TT genotypes in terms of body mass index (BMI), and the levels of triglycerides (TG) and homocysteine (Hcy). Multiple logistic regression analysis revealed that BMI, total cholesterol (TC) level, smoking, plasma Hcy level and a family history of hypertension were the independent risk factors for hypertension in the population studied. The results indicate that the level of plasma Hcy was a risk factor for hypertension in the population studied. However, the mutation of the CBS T833C gene was not concluded to be an important hereditary factor for influencing the level of plasma Hcy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Wang H, Sun H, Chen Y, Ouyang JY, Wang Y, Wang L and Zhang X: Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension. Exp Ther Med 8: 713-718, 2014.
APA
Zhang, Y., Wang, H., Sun, H., Chen, Y., Ouyang, J., Wang, Y. ... Zhang, X. (2014). Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension. Experimental and Therapeutic Medicine, 8, 713-718. https://doi.org/10.3892/etm.2014.1799
MLA
Zhang, Y., Wang, H., Sun, H., Chen, Y., Ouyang, J., Wang, Y., Wang, L., Zhang, X."Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension". Experimental and Therapeutic Medicine 8.3 (2014): 713-718.
Chicago
Zhang, Y., Wang, H., Sun, H., Chen, Y., Ouyang, J., Wang, Y., Wang, L., Zhang, X."Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension". Experimental and Therapeutic Medicine 8, no. 3 (2014): 713-718. https://doi.org/10.3892/etm.2014.1799
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Wang H, Sun H, Chen Y, Ouyang JY, Wang Y, Wang L and Zhang X: Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension. Exp Ther Med 8: 713-718, 2014.
APA
Zhang, Y., Wang, H., Sun, H., Chen, Y., Ouyang, J., Wang, Y. ... Zhang, X. (2014). Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension. Experimental and Therapeutic Medicine, 8, 713-718. https://doi.org/10.3892/etm.2014.1799
MLA
Zhang, Y., Wang, H., Sun, H., Chen, Y., Ouyang, J., Wang, Y., Wang, L., Zhang, X."Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension". Experimental and Therapeutic Medicine 8.3 (2014): 713-718.
Chicago
Zhang, Y., Wang, H., Sun, H., Chen, Y., Ouyang, J., Wang, Y., Wang, L., Zhang, X."Correlation between cystathionine β-synthase T883C genetic polymorphism and primary hypertension". Experimental and Therapeutic Medicine 8, no. 3 (2014): 713-718. https://doi.org/10.3892/etm.2014.1799
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