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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Article

Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction

  • Authors:
    • Yang Yan
    • Yuan Feng
    • Wei Li
    • Jian-Ping Che
    • Guang-Chun Wang
    • Min Liu
    • Jun-Hua Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, P.R. China, Department of Nephrology, Nanjing University Affiliated Drum Tower Hospital, Nanjing, Jiangsu, P.R. China
  • Pages: 727-730
    |
    Published online on: July 14, 2014
       https://doi.org/10.3892/etm.2014.1841
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Abstract

Prevention of renal fibrosis is an important therapeutic strategy in the treatment of obstructive nephropathy. The purpose of the present study was to identify whether the combination of two natural plant‑derived flavanoids, quercetin and hyperoside (QH), could inhibit renal fibrosis in the model of unilateral ureteral obstruction (UUO) in rats. QH mixtures (1:1) were fed to Wistar rats, and UUO ligation was performed on all the rats with the exception of the sham group. Masson's trichrome staining was used for interstitial fibrosis, while immunohistochemistry and western blot analysis were used to detect the expression of α‑smooth muscle actin (SMA) and fibronectin (FN). In the QH group, the expression of SMA and FN was significantly lower than that in the untreated UUO group. In addition, QH administration significantly inhibited the SMA and FN expression of mesangial cells induced by interleukin-1β. Consequently, it was evident that combinational QH therapy prevented UUO‑induced renal fibrosis.Based on these findings, the combinatorial intervention of phytomedicine may present an improved treatment strategy for renal fibrotic disease.
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Copy and paste a formatted citation
Spandidos Publications style
Yan Y, Feng Y, Li W, Che J, Wang G, Liu M and Zheng J: Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction. Exp Ther Med 8: 727-730, 2014.
APA
Yan, Y., Feng, Y., Li, W., Che, J., Wang, G., Liu, M., & Zheng, J. (2014). Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction. Experimental and Therapeutic Medicine, 8, 727-730. https://doi.org/10.3892/etm.2014.1841
MLA
Yan, Y., Feng, Y., Li, W., Che, J., Wang, G., Liu, M., Zheng, J."Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction". Experimental and Therapeutic Medicine 8.3 (2014): 727-730.
Chicago
Yan, Y., Feng, Y., Li, W., Che, J., Wang, G., Liu, M., Zheng, J."Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction". Experimental and Therapeutic Medicine 8, no. 3 (2014): 727-730. https://doi.org/10.3892/etm.2014.1841
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Y, Feng Y, Li W, Che J, Wang G, Liu M and Zheng J: Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction. Exp Ther Med 8: 727-730, 2014.
APA
Yan, Y., Feng, Y., Li, W., Che, J., Wang, G., Liu, M., & Zheng, J. (2014). Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction. Experimental and Therapeutic Medicine, 8, 727-730. https://doi.org/10.3892/etm.2014.1841
MLA
Yan, Y., Feng, Y., Li, W., Che, J., Wang, G., Liu, M., Zheng, J."Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction". Experimental and Therapeutic Medicine 8.3 (2014): 727-730.
Chicago
Yan, Y., Feng, Y., Li, W., Che, J., Wang, G., Liu, M., Zheng, J."Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction". Experimental and Therapeutic Medicine 8, no. 3 (2014): 727-730. https://doi.org/10.3892/etm.2014.1841
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