Protective roles of erythropoiesis‑stimulating proteins in chronic heart failure with anemia

  • Authors:
    • Shuqin Zhou
    • Yugang Zhuang
    • Wei Zhao
    • Bojie Jiang
    • Hui  Pan
    • Xiangyu Zhang
    • Hu Peng
    • Yanqing Chen
  • View Affiliations

  • Published online on: July 14, 2014     https://doi.org/10.3892/etm.2014.1845
  • Pages: 863-870
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Abstract

Anemia is a common comorbidity in patients with chronic heart failure (CHF) and is frequently treated with erythropoiesis‑stimulating proteins (ESPs). Previous studies, however, have been relatively short in duration and have not provided conclusive data on the safety or clinical efficacy of ESP treatment. The aim of this study was to explore the safety and therapeutic effects of ESPs in patients with anemia and CHF. A systematic literature search in EMBASE and MEDLINE from their inception to July 2013 was performed, and clinical studies that evaluated the effects of ESPs among patients with CHF were identified. Randomized clinical trials comparing the effects of ESP treatment with those of placebo treatment or usual care regimes in anemic patients with CHF were included. Nine randomized, controlled trials were identified, comprising 750 patients with CHF and anemia receiving ESP treatment for between three months and one year. ESP treatment had a significantly lower risk of CHF hospitalization [relative risk (RR), 0.47; 95% confidence interval (CI), 0.32‑0.70; P=0.0002] and a moderate reduction in mortality risk (RR, 0.68; 95% CI, 0.38‑1.19; P=0.18). Treatment with ESPs in patients with symptomatic CHF and anemia resulted in significant improvements in hemoglobin, hematocrit and brain natriuretic peptide levels, as well as exercise capacity, renal function, New York Heart Association class and left ventricular ejection fraction. In conclusion, this study found that treatment with ESPs exerts beneficial effects against CHF and is not associated with a higher mortality rate or adverse effects. These outcomes support the instigation of a trial evaluating the treatment of anemia with ESPs in patients with chronic CHF.
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September-2014
Volume 8 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou S, Zhuang Y, Zhao W, Jiang B, Pan H, Zhang X, Peng H and Chen Y: Protective roles of erythropoiesis‑stimulating proteins in chronic heart failure with anemia. Exp Ther Med 8: 863-870, 2014
APA
Zhou, S., Zhuang, Y., Zhao, W., Jiang, B., Pan, H., Zhang, X. ... Chen, Y. (2014). Protective roles of erythropoiesis‑stimulating proteins in chronic heart failure with anemia. Experimental and Therapeutic Medicine, 8, 863-870. https://doi.org/10.3892/etm.2014.1845
MLA
Zhou, S., Zhuang, Y., Zhao, W., Jiang, B., Pan, H., Zhang, X., Peng, H., Chen, Y."Protective roles of erythropoiesis‑stimulating proteins in chronic heart failure with anemia". Experimental and Therapeutic Medicine 8.3 (2014): 863-870.
Chicago
Zhou, S., Zhuang, Y., Zhao, W., Jiang, B., Pan, H., Zhang, X., Peng, H., Chen, Y."Protective roles of erythropoiesis‑stimulating proteins in chronic heart failure with anemia". Experimental and Therapeutic Medicine 8, no. 3 (2014): 863-870. https://doi.org/10.3892/etm.2014.1845