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Article

Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study

Corrigendum in: /etm/10/3/1239
  • Authors:
    • Abdel-Majeed Safer
    • Mohamad Afzal
    • Nemany Hanafy
    • Shaker Mousa
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City 13060, Kuwait, Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA
  • Pages: 787-794
    |
    Published online on: December 24, 2014
       https://doi.org/10.3892/etm.2014.2158
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Abstract

The aim of the present study was to investigate the hepatoprotective effect of green tea extract (GTE) against the hepatic fibrosis induced by carbon tetrachloride (CCl4), ethanol, and dual exposure to CCl4 plus ethanol in rats. In particular, an investigation of the three‑dimensional architecture was conducted using scanning electron microscopy. Various techniques revealed that hepatic fibrosis with intermingled fibers was located between cells in the CCl4, ethanol and combined CCl4 plus ethanol groups. The hepatic fibrosis differed among the ethanol, CCl4 and CCl4 plus ethanol groups in terms of the type, thickness and distribution of fibers. The fibrotic lesions virtually disappeared in all the groups after 25 days of treatment with GTE, returning the architecture of the liver tissue to its normal status. The rats were also found to regain normal body weight and fur color, which had earlier been discolored due to weight loss. The autopsy results also showed that the animal livers returned to the normal shape and color. GTE demonstrated the same clear action in attenuating the hepatofibrosis for all three inducing treatments, by impairing collagen fibers, eliminating lipid peroxidation and returning the liver architecture to normal. GTE presents a safe therapeutic strategy for hepatic fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Safer A, Afzal M, Hanafy N and Mousa S: Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239. Exp Ther Med 9: 787-794, 2015.
APA
Safer, A., Afzal, M., Hanafy, N., & Mousa, S. (2015). Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239. Experimental and Therapeutic Medicine, 9, 787-794. https://doi.org/10.3892/etm.2014.2158
MLA
Safer, A., Afzal, M., Hanafy, N., Mousa, S."Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239". Experimental and Therapeutic Medicine 9.3 (2015): 787-794.
Chicago
Safer, A., Afzal, M., Hanafy, N., Mousa, S."Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239". Experimental and Therapeutic Medicine 9, no. 3 (2015): 787-794. https://doi.org/10.3892/etm.2014.2158
Copy and paste a formatted citation
x
Spandidos Publications style
Safer A, Afzal M, Hanafy N and Mousa S: Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239. Exp Ther Med 9: 787-794, 2015.
APA
Safer, A., Afzal, M., Hanafy, N., & Mousa, S. (2015). Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239. Experimental and Therapeutic Medicine, 9, 787-794. https://doi.org/10.3892/etm.2014.2158
MLA
Safer, A., Afzal, M., Hanafy, N., Mousa, S."Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239". Experimental and Therapeutic Medicine 9.3 (2015): 787-794.
Chicago
Safer, A., Afzal, M., Hanafy, N., Mousa, S."Green tea extract therapy diminishes hepatic fibrosis mediated by dual exposure to carbon tetrachloride and ethanol: A histopathological study Corrigendum in /etm/10/3/1239". Experimental and Therapeutic Medicine 9, no. 3 (2015): 787-794. https://doi.org/10.3892/etm.2014.2158
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