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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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March-2015 Volume 9 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Concurrent insulinoma with mosaic Turner syndrome: A case report

  • Authors:
    • Shaoyun Wang
    • Lijuan Yang
    • Jie Li
    • Yiming Mu
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing 100853, P.R. China, Department of Pathology, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing 100853, P.R. China
  • Pages: 801-804
    |
    Published online on: January 5, 2015
       https://doi.org/10.3892/etm.2015.2167
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Abstract

Turner syndrome is a chromosomal abnormality in which the majority of patients have a 45XO karyotype, while a small number have a 45XO/47XXX karyotype. Congenital adrenal hyperplasia has been previously reported in patients with Turner syndrome. Although insulinomas are the most common type of functioning pancreatic neuroendocrine tumor and have been reported in patients with multiple endocrine neoplasias, the tumors have not been reported in patients with mosaic Turner syndrome. The present study reports the first case of an insulinoma in a patient with 45XO/47XXX mosaic Turner syndrome. The patient suffered from recurrent hypoglycemia, which was relieved following ingestion of glucose or food. A 5‑h glucose tolerance test was performed and the levels of glucose, C‑Peptide and insulin were detected. In addition, computed tomography (CT) and ultrasound scanning were performed to evaluate the possibility of an insulinoma. Pathological examination and karyotyping were performed on a surgical specimen and a whole blood sample, respectively. The patient was found to suffer from premature ovarian failure, and a physical examination was consistent with a diagnosis of Turner syndrome. An ultrasound scan demonstrated streak ovaries and the patient was found to have a 45XO/47XXX karyotype. Furthermore, a lesion was detected in the pancreas following CT scanning, which was identified as an insulinoma following surgical removal and histological examination. In conclusion, the present study reports the first case of an insulinoma in a patient with mosaic Turner syndrome. Since mosaic Turner syndrome and insulinoma are rare diseases, an association may exist that has not been previously identified.
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Copy and paste a formatted citation
Spandidos Publications style
Wang S, Yang L, Li J and Mu Y: Concurrent insulinoma with mosaic Turner syndrome: A case report. Exp Ther Med 9: 801-804, 2015.
APA
Wang, S., Yang, L., Li, J., & Mu, Y. (2015). Concurrent insulinoma with mosaic Turner syndrome: A case report. Experimental and Therapeutic Medicine, 9, 801-804. https://doi.org/10.3892/etm.2015.2167
MLA
Wang, S., Yang, L., Li, J., Mu, Y."Concurrent insulinoma with mosaic Turner syndrome: A case report". Experimental and Therapeutic Medicine 9.3 (2015): 801-804.
Chicago
Wang, S., Yang, L., Li, J., Mu, Y."Concurrent insulinoma with mosaic Turner syndrome: A case report". Experimental and Therapeutic Medicine 9, no. 3 (2015): 801-804. https://doi.org/10.3892/etm.2015.2167
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Yang L, Li J and Mu Y: Concurrent insulinoma with mosaic Turner syndrome: A case report. Exp Ther Med 9: 801-804, 2015.
APA
Wang, S., Yang, L., Li, J., & Mu, Y. (2015). Concurrent insulinoma with mosaic Turner syndrome: A case report. Experimental and Therapeutic Medicine, 9, 801-804. https://doi.org/10.3892/etm.2015.2167
MLA
Wang, S., Yang, L., Li, J., Mu, Y."Concurrent insulinoma with mosaic Turner syndrome: A case report". Experimental and Therapeutic Medicine 9.3 (2015): 801-804.
Chicago
Wang, S., Yang, L., Li, J., Mu, Y."Concurrent insulinoma with mosaic Turner syndrome: A case report". Experimental and Therapeutic Medicine 9, no. 3 (2015): 801-804. https://doi.org/10.3892/etm.2015.2167
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