Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis

  • Authors:
    • Zhifa Lv
    • Ben Wang
    • Xiaojiang Zhou
    • Fucai Wang
    • Yong Xie
    • Huilie Zheng
    • Nonghua Lv
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China, School of Public Health, Nanchang University, Nanchang, Jiangxi, P.R. China
  • Pages: 707-716
    |
    Published online on: January 9, 2015
       https://doi.org/10.3892/etm.2015.2174
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine whether probiotics could help to improve the eradication rates and reduce the side effects associated with anti‑Helicobacter pylori treatment, and to investigate the optimal time and duration of probiotic administration during the treatment, thus providing clinical practice guidelines for eradication success worldwide. By searching Pubmed, Embase, the Cochrane Central Register of Controlled Trials and the Science Citation Index, all the randomized controlled trials (RCTs) comparing probiotics as adjuvant agents of anti‑H. pylori standard triple‑therapy regimens with placebo or no treatment were selected. Statistical analysis was performed with the Comprehensive Meta Analysis Software. Subgroup, meta‑regression and sensitivity analyses were also carried out. Twenty‑one RCTs involving a total of 3,814 participants met the inclusion criteria. The pooled eradication rates of the probiotic group were 80.3% (1,709/2,128) by intention‑to‑treat (ITT) and 83.8% (1,709/2,039) by pro‑protocol analyses; the pooled relative risk (RR) by ITT for probiotic supplementation versus treatment without probiotics was 1.12 [95% confidence interval (CI), 1.06‑1.19]. A reduced risk of overall H. pylori therapy‑related adverse effects was also found with probiotic supplementation (RR, 0.60; 95% CI, 0.40‑0.91). The subgroup analyses showed that probiotic supplementation prior and subsequent to the treatment regimen both improved eradication rates for H. pylori infection. Furthermore, probiotic treatment lasting >2 weeks and including Lactobacillus or multiple probiotic strains significantly enhanced the efficacy. In conclusion, supplementation with probiotics for H. pylori eradication may be effective in increasing eradication rates and decreasing therapy‑related side effects. Probiotic administration prior or subsequent to therapy and for a duration of >2 weeks may increase the eradication efficacy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Go MF: Review article: natural history and epidemiology of Helicobacter pylori infection. Aliment Pharmacol Ther. 16(Suppl 1): 3–15. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Chey WD and Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 102:1808–1825. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Malfertheiner P, Megraud F, O’Morain CA, et al: Management of Helicobacter pylori infection - the Maastricht IV/Florence consensus report. Gut. 61:646–664. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Bell GD, Powell K, Burridge SM, et al: Experience with ‘triple’ anti-Helicobacter pylori eradication therapy: side effects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance. Aliment Pharmacol Ther. 6:427–435. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Bhatia SJ, Kochar N, Abraham P, Nair NG and Mehta AP: Lactobacillus acidophilus inhibits growth of Campylobacter pylori in vitro. J Clin Microbiol. 27:2328–2330. 1989.PubMed/NCBI

6 

Mukai T, Asasaka T, Sato E, et al: Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. FEMS Immunol Med Microbiol. 32:105–110. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Johnson-Henry KC, Mitchell DJ, Avitzur Y, et al: Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice. Dig Dis Sci. 49:1095–1102. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Hsieh PS, Tsai YC, Chen YC, et al: Eradication of Helicobacter pylori infection by the probiotic strains Lactobacillus johnsonii MH-68 and L. salivarius ssp salicinius AP-32. Helicobacter. 17:466–477. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Tursi A, Brandimarte G, Giorgetti GM and Modeo ME: Effect of Lactobacillus casei supplementation on the effectiveness and tolerability of a new second-line 10-day quadruple therapy after failure of a first attempt to cure Helicobacter pylori infection. Med Sci Monit. 10:CR662–CR666. 2004.PubMed/NCBI

10 

Lionetti E, Indrio F, Pavone L, et al: Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 15:79–87. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Ozdil K, Calhan T, Sahin A, et al: Levofloxacin based sequential and triple therapy compared with standard plus probiotic combination for Helicobacter pylori eradication. Hepatogastroenterology. 58:1148–1152. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Yoon H, Kim N, Kim JY, et al: Effects of multistrain probiotic-containing yogurt on second-line triple therapy for Helicobacter pylori infection. J Gastroenterol Hepatol. 26:44–48. 2011. View Article : Google Scholar

13 

Scaccianoce G, Zullo A, Hassan C, et al: Triple therapies plus different probiotics for Helicobacter pylori eradication. Eur Rev Med Pharmacol Sci. 12:251–256. 2008.PubMed/NCBI

14 

Ahmad K, Fatemeh F, Mehri N and Maryam S: Probiotics for the treatment of pediatric Helicobacter pylori infection: a randomized double blind clinical trial. Iran J Pediatr. 23:79–84. 2013.PubMed/NCBI

15 

Tong JL, Ran ZH, Shen J, Zhang CX and Xiao SD: Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther. 25:155–168. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Szajewska H, Horvath A and Piwowarczyk A: Meta-analysis: the effects of Saccharomyces boulardii supplementation on Helicobacter pylori eradication rates and side effects during treatment. Aliment Pharmacol Ther. 32:1069–1079. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Zou J, Dong J and Yu X: Meta-analysis: Lactobacillus containing quadruple therapy versus standard triple first-line therapy for Helicobacter pylori eradication. Helicobacter. 14:97–107. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Wang ZH, Gao QY and Fang JY: Meta-analysis of the efficacy and safety of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation in Helicobacter pylori eradication therapy. J Clin Gastroenterol. 47:25–32. 2013. View Article : Google Scholar

19 

Sachdeva A and Nagpal J: Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials. Eur J Gastroenterol Hepatol. 21:45–53. 2009. View Article : Google Scholar

20 

Zheng X, Lyu L and Mei Z: Lactobacillus-containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis. Rev Esp Enferm Dig. 105:445–453. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Shavakhi A, Tabesh E, Yaghoutkar A, et al: The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-controlled triple-blind study. Helicobacter. 18:280–284. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Navarro-Rodriguez T, Silva FM, Barbuti RC, et al: Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study. BMC Gastroenterol. 13:562013. View Article : Google Scholar : PubMed/NCBI

23 

Matsushima M and Takagi A: ‘Is it effective?’ to ‘How to use it?’: the era has changed in probiotics and functional food products against Helicobacter pylori infection. J Gastroenterol Hepatol. 27:851–853. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Boyanova L and Mitov I: Coadministration of probiotics with antibiotics: why, when and for how long? Expert Rev Anti Infect Ther. 10:407–409. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Liberati A, Altman DG, Tetzlaff J, et al: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 339:b27002009. View Article : Google Scholar : PubMed/NCBI

26 

Jadad AR, Moore RA, Carroll D, et al: Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 17:1–12. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Downs SH and Black N: The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 52:377–384. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Sahagún-Flores JE, López-Peña LS, de la Cruz-Ramírez Jaimes J, et al: Eradication of Helicobacter pylori: triple treatment scheme plus Lactobacillus vs. triple treatment alone. Cir Cir. 75:333–336. 2007.(In Spanish).

29 

Ziemniak W: Efficacy of Helicobacter pylori eradication taking into account its resistance to antibiotics. J Physiol Pharmacol. 57(Suppl 3): 123–141. 2006.PubMed/NCBI

30 

Sheu BS, Cheng HC, Kao AW, et al: Pretreatment with Lactobacillus- and Bifidobacterium-containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr. 83:864–869. 2006.PubMed/NCBI

31 

Lionetti E, Miniello VL, Castellaneta SP, et al: Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial. Aliment Pharmacol Ther. 24:1461–1468. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Manfredi M, Bizzarri B, Sacchero RI, et al: Helicobacter pylori infection in clinical practice: probiotics and a combination of probiotics + lactoferrin improve compliance, but not eradication, in sequential therapy. Helicobacter. 17:254–263. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Xu C, Xiao L and Zou H: Effect of birid triple viable on peptic ulcer patients with Helicobacter pylori infection. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 35:1000–1004. 2010.(In Chinese). PubMed/NCBI

34 

Park SK, Park DI, Choi JS, et al: The effect of probiotics on Helicobacter pylori eradication. Hepatogastroenterology. 54:2032–2036. 2007.

35 

Bekar O, Yilmaz Y and Gulten M: Kefir improves the efficacy and tolerability of triple therapy in eradicating Helicobacter pylori. J Med Food. 14:344–347. 2011. View Article : Google Scholar

36 

Nista EC, Candelli M, Cremonini F, et al: Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial. Aliment Pharmacol Ther. 20:1181–1188. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Canducci F, Armuzzi A, Cremonini F, et al: A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. Aliment Pharmacol Ther. 14:1625–1629. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Wang YH and Huang Y: Effect of Lactobacillus acidophilus and Bifidobacterium bifidum supplementation to standard triple therapy on Helicobacter pylori eradication and dynamic changes in intestinal flora. World J Microbiol Biotechnol. 30:847–853. 2014. View Article : Google Scholar

39 

Dajani AI, Abu Hammour AM, Yang DH, et al: Do probiotics improve eradication response to Helicobacter pylori on standard triple or sequential therapy? Saudi J Gastroenterol. 19:113–120. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Armuzzi A, Cremonini F, Bartolozzi F, et al: The effect of oral administration of Lactobacillus GG on antibiotic-associated gastrointestinal side-effects during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther. 15:163–169. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Armuzzi A, Cremonini F, Ojetti V, et al: Effect of Lactobacillus GG supplementation on antibiotic-associated gastrointestinal side effects during Helicobacter pylori eradication therapy: a pilot study. Digestion. 63:1–7. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Cremonini F, Di Caro S, Covino M, et al: Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol. 97:2744–2749. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Sheu BS, Wu JJ, Lo CY, et al: Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther. 16:1669–1675. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Myllyluoma E, Veijola L, Ahlroos T, et al: Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy - a placebo-controlled, double-blind randomized pilot study. Aliment Pharmacol Ther. 21:1263–1272. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Sýkora J, Valecková K, Amlerová J, et al: Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study. J Clin Gastroenterol. 39:692–698. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Plewińska EM, Płaneta-Małecka I, Bąk-Romaniszyn L, Czkwianianc E and Małecka-Panas E: Probiotics in the treatment of Helicobacter pylori infection in children. Gastroenterologia Polska. 13:315–319. 2006.

47 

de Bortoli N, Leonardi G, Ciancia E, et al: Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics. Am J Gastroenterol. 102:951–956. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Cindoruk M, Erkan G, Karakan T, Dursun A and Unal S: Efficacy and safety of Saccharomyces boulardii in the 14-day triple anti-Helicobacter pylori therapy: a prospective randomized placebo-controlled double-blind study. Helicobacter. 12:309–316. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Kim MN, Kim N, Lee SH, et al: The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication. Helicobacter. 13:261–268. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Hurduc V, Plesca D, Dragomir D, Sajin M and Vandenplas Y: A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children. Acta Paediatr. 98:127–131. 2009. View Article : Google Scholar

51 

Szajewska H, Albrecht P and Topczewska-Cabanek A: Randomized, double-blind, placebo-controlled trial: effect of Lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. J Pediatr Gastroenterol Nutr. 48:431–436. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Song MJ, Park DI, Park JH, et al: The effect of probiotics and mucoprotective agents on PPI-based triple therapy for eradication of Helicobacter pylori. Helicobacter. 15:206–213. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Yaşar B, Abut E, Kayadıbı H, et al: Efficacy of probiotics in Helicobacter pylori eradication therapy. Turk J Gastroenterol. 21:212–217. 2010.

54 

Medeiros JA, Gonçalves TM, Boyanova L, et al: Evaluation of Helicobacter pylori eradication by triple therapy plus Lactobacillus acidophilus compared to triple therapy alone. Eur J Clin Microbiol Infect Dis. 30:555–559. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Deguchi R, Nakaminami H, Rimbara E, et al: Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy. J Gastroenterol Hepatol. 27:888–892. 2012. View Article : Google Scholar :

56 

Du YQ, Su T, Fan JG, et al: Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection. World J Gastroenterol. 18:6302–6307. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Tolone S, Pellino V, Vitaliti G, Lanzafame A and Tolone C: Evaluation of Helicobacter pylori eradication in pediatric patients by triple therapy plus lactoferrin and probiotics compared to triple therapy alone. Ital J Pediatr. 38:632012. View Article : Google Scholar : PubMed/NCBI

58 

Gotteland M, Brunser O and Cruchet S: Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori? Aliment Pharmacol Ther. 23:1077–1086. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Yang YJ and Sheu BS: Probiotics-containing yogurts suppress Helicobacter pylori load and modify immune response and intestinal microbiota in the Helicobacter pylori-infected children. Helicobacter. 17:297–304. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Kwon HK, Kim GC, Kim Y, et al: Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clin Immunol. 146:217–227. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Sultana R, McBain AJ and O’Neill CA: Strain-dependent augmentation of tight-junction barrier function in human primary epidermal keratinocytes by Lactobacillus and Bifidobacterium lysates. Appl Environ Microbiol. 79:4887–4894. 2013. View Article : Google Scholar : PubMed/NCBI

62 

Yeung CY, Chiang Chiau JS, Chan WT, et al: In vitro prevention of Salmonella lipopolysaccharide-induced damages in epithelial barrier function by various Lactobacillus strains. Gastroenterol Res Pract. 2013:9732092013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lv Z, Wang B, Zhou X, Wang F, Xie Y, Zheng H and Lv N: Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis. Exp Ther Med 9: 707-716, 2015.
APA
Lv, Z., Wang, B., Zhou, X., Wang, F., Xie, Y., Zheng, H., & Lv, N. (2015). Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis. Experimental and Therapeutic Medicine, 9, 707-716. https://doi.org/10.3892/etm.2015.2174
MLA
Lv, Z., Wang, B., Zhou, X., Wang, F., Xie, Y., Zheng, H., Lv, N."Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis". Experimental and Therapeutic Medicine 9.3 (2015): 707-716.
Chicago
Lv, Z., Wang, B., Zhou, X., Wang, F., Xie, Y., Zheng, H., Lv, N."Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis". Experimental and Therapeutic Medicine 9, no. 3 (2015): 707-716. https://doi.org/10.3892/etm.2015.2174
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Z, Wang B, Zhou X, Wang F, Xie Y, Zheng H and Lv N: Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis. Exp Ther Med 9: 707-716, 2015.
APA
Lv, Z., Wang, B., Zhou, X., Wang, F., Xie, Y., Zheng, H., & Lv, N. (2015). Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis. Experimental and Therapeutic Medicine, 9, 707-716. https://doi.org/10.3892/etm.2015.2174
MLA
Lv, Z., Wang, B., Zhou, X., Wang, F., Xie, Y., Zheng, H., Lv, N."Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis". Experimental and Therapeutic Medicine 9.3 (2015): 707-716.
Chicago
Lv, Z., Wang, B., Zhou, X., Wang, F., Xie, Y., Zheng, H., Lv, N."Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta‑analysis". Experimental and Therapeutic Medicine 9, no. 3 (2015): 707-716. https://doi.org/10.3892/etm.2015.2174
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team