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Article

Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients

  • Authors:
    • Jia Jiao
    • Min Wang
    • Jianfeng Zhang
    • Kangjun Shen
    • Xiaobo Liao
    • Xinmin Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 1051-1057
    |
    Published online on: January 9, 2015
       https://doi.org/10.3892/etm.2015.2175
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Abstract

The aim of the present study was to assess whether procalcitonin (PCT) can be used as a diagnostic marker for ventilator‑associated pneumonia (VAP) in cardiac surgery patients. Between January 2012 and June 2013, a total of 92 patients were recruited and divided into non‑VAP (59 patients) and VAP (33 patients) groups. The preoperative and postoperative characteristics of the patients were recorded. Serum levels of PCT, interleukin (IL)‑6 and C‑reactive protein (CRP) were measured using an electrochemiluminescence immunoassay. Subsequently, receiver operating characteristic curves of the PCT, IL‑6 and CRP levels were constructed. In addition, associations between the sequential organ failure assessment (SOFA) scores and the serum levels of PCT, IL‑6 and CRP in the VAP patients were analyzed. No statistically significant difference was observed between the non‑VAP and VAP patients in the occurrence of postoperative complications. However, the SOFA scores (days 1 and 7), the duration of stay in the intensive care unit and the mechanical ventilation time were all significantly higher in the VAP group when compared with the non‑VAP group (P<0.05). The optimum PCT cut‑off value for VAP diagnosis on day 1 was 5.0 ng/ml, with a sensitivity of 91% and a specificity of 71%. The serum PCT levels on days 1 and 7 were found to correlate positively with the SOFA scores (r=0.54 and r=0.66 for days 1 and 7, respectively). Therefore, the results suggested that serum PCT may be used as diagnostic marker for VAP in patients following cardiac surgery.
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1 

Hortal J, Giannella M, Pérez MJ, et al: Incidence and risk factors for ventilator-associated pneumonia after major heart surgery. Intensive Care Med. 35:1518–1525. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Vijarnsorn C, Winijkul G, Laohaprasitiporn D, et al: Postoperative fever and major infections after pediatric cardiac surgery. J Med Assoc Thai. 95:761–770. 2012.PubMed/NCBI

3 

Melsen WG, Rovers MM, Groenwold RH, et al: Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis. 13:665–671. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Hortal J, Muñoz P, Cuerpo G, Litvan H, Rosseel PM and Bouza E; European Study Group on Nosocomial Infections; European Workgroup of Cardiothoracic Intensivists. Ventilator-associated pneumonia in patients undergoing major heart surgery: an incidence study in Europe. Crit Care. 13:R802009. View Article : Google Scholar : PubMed/NCBI

5 

Roeleveld PP, Guijt D, Kuijper EJ, Hazekamp MG, de Wilde RB and de Jonge E: Ventilator-associated pneumonia in children after cardiac surgery in The Netherlands. Intensive Care Med. 37:1656–1663. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Tamayo E, Álvarez FJ, Martínez-Rafael B, et al: Valladolid Sepsis Study Group: Ventilator-associated pneumonia is an important risk factor for mortality after major cardiac surgery. J Crit Care. 27:18–25. 2012. View Article : Google Scholar

7 

Becker KL, Snider R and Nylen ES: Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med. 36:941–952. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J and Bohuon C: High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 341:515–518. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Riedel S: Procalcitonin and the role of biomarkers in the diagnosis and management of sepsis. Diagn Microbiol Infect Dis. 73:221–227. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Rea-Neto A, Youssef NC, Tuche F, et al: Diagnosis of ventilator-associated pneumonia: a systematic review of the literature. Crit Care. 12:R562008. View Article : Google Scholar : PubMed/NCBI

11 

Sponholz C, Sakr Y, Reinhart K and Brunkhorst F: Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. Crit Care. 10:R1452006. View Article : Google Scholar : PubMed/NCBI

12 

Adib-Conquy M, Monchi M, Goulenok C, et al: Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection. Shock. 28:406–410. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Sinning JM, Scheer AC, Adenauer V, et al: Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantation. Eur Heart J. 33:1459–1468. 2012. View Article : Google Scholar : PubMed/NCBI

14 

American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 171:388–416. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 22:707–710. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Duflo F, Debon R, Monneret G, Bienvenu J, Chassard D and Allaouchiche B: Alveolar and serum procalcitonin: diagnostic and prognostic value in ventilator-associated pneumonia. Anesthesiology. 96:74–79. 2002. View Article : Google Scholar

17 

Oppert M, Reinicke A, Müller C, Barckow D, Freix U and Eckardt KU: Elevations in procalcitonin but not C-reactive protein are associated with pneumonia after cardiopulmonary resuscitation. Resuscitation. 53:167–170. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Luyt CE, Combes A, Reynaud C, et al: Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia. Intensive Care Med. 34:1434–1440. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Hensel M, Volk T, Döcke WD, et al: Hyperprocalcitonemia in patients with noninfectious SIRS and pulmonary dysfunction associated with cardiopulmonary bypass. Anesthesiology. 89:93–104. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Amin DN, Pruitt JC and Schuetz P: Influence of major cardiopulmonary surgery on serum levels of procalcitonin and other inflammatory markers. Anaesth Intensive Care. 40:760–766. 2012.PubMed/NCBI

21 

Beghetti M, Rimensberger PC, Kalangos A, Habre W and Gervaix A: Kinetics of procalcitonin, interleukin 6 and C-reactive protein after cardiopulmonary-bypass in children. Cardiol Young. 13:161–167. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Meisner M, Rauschmayer C, Schmidt J, et al: Early increase of procalcitonin after cardiovascular surgery in patients with postoperative complications. Intensive Care Med. 28:1094–1102. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Jebali MA, Hausfater P, Abbes Z, Aouni Z, Riou B and Ferjani M: Assessment of the accuracy of procalcitonin to diagnose postoperative infection after cardiac surgery. Anesthesiology. 107:232–238. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Prat C, Ricart P, Ruyra X, et al: Serum concentrations of procalcitonin after cardiac surgery. J Card Surg. 23:627–632. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Meisner M, Tschaikowsky K, Palmaers T and Schmidt J: Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. Crit Care. 3:45–50. 1999. View Article : Google Scholar

26 

Haasper C, Kalmbach M, Dikos GD, et al: Prognostic value of procalcitonin (PCT) and/or interleukin-6 (IL-6) plasma levels after multiple trauma for the development of multi organ dysfunction syndrome (MODS) or sepsis. Technol Health Care. 18:89–100. 2010.PubMed/NCBI

27 

Ramirez P, Garcia MA, Ferrer M, et al: Sequential measurements of procalcitonin levels in diagnosing ventilator-associated pneumonia. Eur Respir J. 31:356–362. 2008. View Article : Google Scholar

28 

Hammer S, Fuchs AT, Rinker C, et al: Interleukin-6 and procalcitonin in serum of children undergoing cardiac surgery with cardiopulmonary bypass. Acta Cardiol. 59:624–629. 2004. View Article : Google Scholar

29 

Denizot Y, Lorgeot V, Cornu E and Nathan N: Plasma leukaemia inhibitory factor, interleukin 6 and soluble interleukin 6 receptor levels during cardiopulmonary bypass with extracorporeal circulation. Cytokine. 10:303–306. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Póvoa P: C-reactive protein: a valuable marker of sepsis. Intensive Care Med. 28:235–243. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiao J, Wang M, Zhang J, Shen K, Liao X and Zhou X: Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients. Exp Ther Med 9: 1051-1057, 2015.
APA
Jiao, J., Wang, M., Zhang, J., Shen, K., Liao, X., & Zhou, X. (2015). Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients. Experimental and Therapeutic Medicine, 9, 1051-1057. https://doi.org/10.3892/etm.2015.2175
MLA
Jiao, J., Wang, M., Zhang, J., Shen, K., Liao, X., Zhou, X."Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients". Experimental and Therapeutic Medicine 9.3 (2015): 1051-1057.
Chicago
Jiao, J., Wang, M., Zhang, J., Shen, K., Liao, X., Zhou, X."Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1051-1057. https://doi.org/10.3892/etm.2015.2175
Copy and paste a formatted citation
x
Spandidos Publications style
Jiao J, Wang M, Zhang J, Shen K, Liao X and Zhou X: Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients. Exp Ther Med 9: 1051-1057, 2015.
APA
Jiao, J., Wang, M., Zhang, J., Shen, K., Liao, X., & Zhou, X. (2015). Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients. Experimental and Therapeutic Medicine, 9, 1051-1057. https://doi.org/10.3892/etm.2015.2175
MLA
Jiao, J., Wang, M., Zhang, J., Shen, K., Liao, X., Zhou, X."Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients". Experimental and Therapeutic Medicine 9.3 (2015): 1051-1057.
Chicago
Jiao, J., Wang, M., Zhang, J., Shen, K., Liao, X., Zhou, X."Procalcitonin as a diagnostic marker of ventilator‑associated pneumonia in cardiac surgery patients". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1051-1057. https://doi.org/10.3892/etm.2015.2175
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