Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease

  • Authors:
    • Yan Zhu
    • Chengshan Li
    • Aichen Sun
    • Yuanye Wang
    • Shengnian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of ICU, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277102, P.R. China, Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 1013-1017
    |
    Published online on: January 14, 2015
       https://doi.org/10.3892/etm.2015.2179
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the potential clinical application of the genetic marker microRNA (miRNA)‑210 in the cerebrospinal fluid (CSF) and serum of patients with Alzheimer's disease (AD). The enrolled patients were divided into the mild cognitive impairment (MCI) and AD groups. Healthy individuals were used as the controls. The mRNA and protein expression of vascular endothelial growth factor (VEGF) in the CSF and serum samples was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis, respectively. The expression of miRNA‑210 in the CSF and serum was detected by RT‑qPCR. The results revealed that the mRNA and protein expression levels of VEGF in the CSF and serum were decreased in the MCI and AD groups compared with those in the control group. The greater the severity of the dementia, the lower the mRNA and protein expression of VEGF. Similar to the trend observed for VEGF, the miRNA‑210 expression in the CSF and serum decreased as the severity of the AD increased. miRNA‑210 is thus not only indicative of AD pathogenesis, but may also provide novel insights into the prevention and treatment of the disease.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Duran-Aniotz C, Martínez G and Hetz C: Memory loss in Alzheimer’s disease: are the alterations in the UPR network involved in the cognitive impairment? Front Aging Neurosci. 6:82014. View Article : Google Scholar

2 

de la Monte SM and Tong M: Brain metabolic dysfunction at the core of Alzheimer’s disease. Biochem Pharmacol. 88:548–559. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Roberts E, Cossigny DA and Quan GM: The role of vascular endothelial growth factor in metastatic prostate cancer to the skeleton. Prostate Cancer. 2013:4183402013. View Article : Google Scholar

4 

Mao X, Wang T, Liu Y, et al: N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring VEGF/HO-1 signaling in diabetic rats. PLoS One. 8:e689492013. View Article : Google Scholar

5 

In Lee S, Ji MR, Jang YJ, et al: Characterization and miRNA-mediated posttranscriptional regulation of vitelline membrane outer layer protein I in the adult chicken oviduct. In Vitro Cell Dev Biol Anim. Nov 8–2014.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

6 

Liu SC, Chuang SM, Hsu CJ, et al: CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression. Cell Death Dis. 5:e14852014. View Article : Google Scholar : PubMed/NCBI

7 

Li H, Wang Y, Liu F, et al: Dynamic expressions of hypoxia-inducible factor-1α and its target gene miRNA-210 and vascular endothelial growth factor after renal ischemia-reperfusion injury. Zhong Hua Shi Yan Wai Ke Za Zhi. 28:2074–2076. 2011.(In Chinese).

8 

Azheimer’s Association. 2011 Alzheimer’s disease facts and figures. Alzheimers Dement. 7:208–244. 2011. View Article : Google Scholar

9 

Petrella JR: Neuroimaging and the search for a cure for Alzheimer disease. Radiology. 269:671–691. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Li S, Okonkwo O, Albert M and Wang MC: Variation in variables that predict progression from MCI to AD dementia over duration of follow-up. Am J Alzheimers Dis (Columbia). 2:12–28. 2013.

11 

Hill CB, Grandgeorge SH and Bavis RW: Developmental hyperoxia alters CNS mechanisms underlying hypoxic ventilatory depression in neonatal rats. Respir Physiol Neurobiol. 189:489–505. 2013. View Article : Google Scholar

12 

Sopova K, Gatsiou K, Stellos K and Laske C: Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer’s disease: from pathophysiology to novel treatment strategies. Curr Alzheimer Res. 11:27–39. 2014. View Article : Google Scholar

13 

Damodaran T, Hassan Z, Navaratnam V, et al: Time course of motor and cognitive functions after chronic cerebral ischemia in rats. Behav Brain Res. 275:252–258. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Solerte SB, Ferrari E, Cuzzoni G, et al: Decreased release of the angiogenic peptide vascular endothelial growth factor in Alzheimer’s disease: recovering effect with insulin and DHEA sulfate. Dement Geriatr Cogn Disord. 19:1–10. 2005. View Article : Google Scholar

15 

Pikula A, Beiser AS, Chen TC, et al: Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. Stroke. 44:2768–2775. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Cheng CJ, Bahal R, Babar IA, et al: MicroRNA silencing for cancer therapy targeted to the tumor microenvironment. Nature. Nov 17–2014.(Epub ahead of print). View Article : Google Scholar

17 

Jayanthy A and Selaturi V: Light regulated microRNAs. Photochem Photobiol. Nov 10–2014.(epub ahead of print).

18 

Alaiti MA, Ishikawa M, Masuda H, et al: Up-regulation of miR-210 by vascular endothelial growth factor in ex vivo expanded CD34+ cells enhances cell-mediated angiogenesis. J Cell Mol Med. 16:2413–2421. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Zeng L, He X, Wang Y, et al: MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain. Gene Ther. 21:37–43. 2014. View Article : Google Scholar

20 

Lou Y, Gao F, Xie A, et al: MicroRNA-210 modified human umbilical vein endothelial cells induce capillary formation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 26:587–591. 2012.(In Chinese). PubMed/NCBI

21 

Shoji T, Nakasa T, Yamasaki K, et al: The effect of intra-articular injection of microRNA-210 on ligament healing in a rat model. Am J Sports Med. 40:2470–2478. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Nagpure BV and Bian JS: Hydrogen sulfide inhibits A2A adenosine receptor agonist induced β-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway. PLoS One. 9:e885082014. View Article : Google Scholar

23 

Zhang Y, Pan C, Wu X, et al: Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons. Front Cell Neurosci. 8:142014. View Article : Google Scholar : PubMed/NCBI

24 

Chen Y, Wang B, Liu D, et al: Hsp90 chaperone inhibitor 17-AAG attenuates A β-induced synaptic toxicity and memory impairment. J Neurosci. 34:2464–2470. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Li C, Sun A, Wang Y and Zhou S: Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease. Exp Ther Med 9: 1013-1017, 2015.
APA
Zhu, Y., Li, C., Sun, A., Wang, Y., & Zhou, S. (2015). Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease. Experimental and Therapeutic Medicine, 9, 1013-1017. https://doi.org/10.3892/etm.2015.2179
MLA
Zhu, Y., Li, C., Sun, A., Wang, Y., Zhou, S."Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease". Experimental and Therapeutic Medicine 9.3 (2015): 1013-1017.
Chicago
Zhu, Y., Li, C., Sun, A., Wang, Y., Zhou, S."Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1013-1017. https://doi.org/10.3892/etm.2015.2179
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Li C, Sun A, Wang Y and Zhou S: Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease. Exp Ther Med 9: 1013-1017, 2015.
APA
Zhu, Y., Li, C., Sun, A., Wang, Y., & Zhou, S. (2015). Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease. Experimental and Therapeutic Medicine, 9, 1013-1017. https://doi.org/10.3892/etm.2015.2179
MLA
Zhu, Y., Li, C., Sun, A., Wang, Y., Zhou, S."Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease". Experimental and Therapeutic Medicine 9.3 (2015): 1013-1017.
Chicago
Zhu, Y., Li, C., Sun, A., Wang, Y., Zhou, S."Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease". Experimental and Therapeutic Medicine 9, no. 3 (2015): 1013-1017. https://doi.org/10.3892/etm.2015.2179
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team