Efficacy of different irrigation solutions on the early debridement of open fracture in rats

Cheng,Qian; Zhang,Xiao‑Fei; Di,Dong‑Hua; Zhao,Guo‑Yang; Cui,Xue‑Wen

doi:10.3892/etm.2015.2325

Efficacy of different irrigation solutions on the early debridement of open fracture in rats

Authors:
- Qian Cheng
- Xiao‑Fei Zhang
- Dong‑Hua Di
- Guo‑Yang Zhao
- Xue‑Wen Cui
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Affiliations: Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China, Department of Obstetrics and Gynecology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China
Published online on: March 2, 2015 https://doi.org/10.3892/etm.2015.2325
Pages: 1589-1592
Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Contaminating bacteria are only found on wound surfaces in the initial stages of open fractures; therefore, effective debridement is critical for bacterial infection prevention and the reduction of inflammatory reactions. Various irrigation solutions are currently being used; however, a comprehensive study on their efficacy is lacking. In the present study, a comparison of the effects of normal saline, iodophor and hydrogen peroxide as the irrigation solutions for debridement of open femur fractures in rat models was conducted. It was revealed that all three solutions were comparably effective in bacterial removal while normal saline was superior in minimizing adverse wound inflammation; therefore, the use of normal saline for routine debridement is recommended in the early‑stage treatment of open fractures in the trauma clinic and in relief fieldwork.

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