Efficacy of different irrigation solutions on the early debridement of open fracture in rats

Cheng,Qian; Zhang,Xiao‑Fei; Di,Dong‑Hua; Zhao,Guo‑Yang; Cui,Xue‑Wen

doi:10.3892/etm.2015.2325

May-2015 Volume 9 Issue 5

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May-2015 Volume 9 Issue 5

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Article Open Access

Efficacy of different irrigation solutions on the early debridement of open fracture in rats

Authors:
- Qian Cheng
- Xiao‑Fei Zhang
- Dong‑Hua Di
- Guo‑Yang Zhao
- Xue‑Wen Cui
View Affiliations / Copyright

Affiliations: Department of Orthopedics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China, Department of Obstetrics and Gynecology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China

Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1589-1592
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Published online on: March 2, 2015

https://doi.org/10.3892/etm.2015.2325
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Abstract

Contaminating bacteria are only found on wound surfaces in the initial stages of open fractures; therefore, effective debridement is critical for bacterial infection prevention and the reduction of inflammatory reactions. Various irrigation solutions are currently being used; however, a comprehensive study on their efficacy is lacking. In the present study, a comparison of the effects of normal saline, iodophor and hydrogen peroxide as the irrigation solutions for debridement of open femur fractures in rat models was conducted. It was revealed that all three solutions were comparably effective in bacterial removal while normal saline was superior in minimizing adverse wound inflammation; therefore, the use of normal saline for routine debridement is recommended in the early‑stage treatment of open fractures in the trauma clinic and in relief fieldwork.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Efficacy of different irrigation solutions on the early debridement of open fracture in rats

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