Study on the behavioral changes of a post‑stroke depression rat model

  • Authors:
    • Chunfang Wu
    • Junhe Zhang
    • Yong Chen
  • View Affiliations

  • Published online on: April 24, 2015     https://doi.org/10.3892/etm.2015.2450
  • Pages: 159-163
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Abstract

The aim of this study was to observe the changes in the levels of learning and memory in a post‑stroke depression (PSD) rat model. Forty‑eight Wistar rats were randomly divided into three groups: Group A (normal group), group B (stroke group) and group C (PSD group). Each group comprised 16 rats. Three and 7 days after successful modeling, the open‑field, sucrose solution consumption and forced swimming tests were performed, so as to evaluate behavioral changes in the three groups of rats. The sucrose solution consumption of the rats in group B was lower than that in group A in the tests at the two time‑points, but only the difference after 7 days was statistically significant (P<0.05). The sucrose solution consumption of the rats in group C was lower than the consumption of those in groups A and B, and the differences were statistically significant (P<0.05). The open‑field test results showed that the horizontal and vertical activity scores of the rats in group B were significantly lower than those of the rats in group A (P<0.05). Furthermore, the two test levels and the vertical activity scores of the rats in group C were significantly lower than those of the rats in groups A and B (P<0.05). The immobility time of the rats in the forced swimming test was higher in group B than that in group A at the two time‑points, but the difference was only statistically significant after 7 days (P<0.05). The immobility time of the rats in group C was significantly higher than that in groups A and B (P<0.01). In conclusion, rats with PSD exhibited a significantly reduced memory capacity and altered behavior. The changes in the PSD rats were more severe than those in the rats in the stroke group.
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July-2015
Volume 10 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wu C, Zhang J and Chen Y: Study on the behavioral changes of a post‑stroke depression rat model. Exp Ther Med 10: 159-163, 2015
APA
Wu, C., Zhang, J., & Chen, Y. (2015). Study on the behavioral changes of a post‑stroke depression rat model. Experimental and Therapeutic Medicine, 10, 159-163. https://doi.org/10.3892/etm.2015.2450
MLA
Wu, C., Zhang, J., Chen, Y."Study on the behavioral changes of a post‑stroke depression rat model". Experimental and Therapeutic Medicine 10.1 (2015): 159-163.
Chicago
Wu, C., Zhang, J., Chen, Y."Study on the behavioral changes of a post‑stroke depression rat model". Experimental and Therapeutic Medicine 10, no. 1 (2015): 159-163. https://doi.org/10.3892/etm.2015.2450