Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2015 Volume 10 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 10 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer

  • Authors:
    • Jun Liu
    • Yang Xiao
    • Wei Wei
    • Jian‑Xiong Guo
    • Yang‑Chen Liu
    • Xiao‑Hong Huang
    • Rong‑Xia Zhang
    • Yi‑Jia Wu
    • Juan Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Taixing People's Hospital, Medical School of Yangzhou University, Taixing, Jiangsu 225400, P.R. China
  • Pages: 379-385
    |
    Published online on: May 12, 2015
       https://doi.org/10.3892/etm.2015.2489
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Triple‑negative breast cancer (TNBC) is not amenable to current targeted therapies and carries a poor prognosis; however, a specific systemic regimen cannot yet be recommended. The optimal duration of oxaliplatin (OXA) and S‑1 combinatorial chemotherapy in patients with advanced breast cancer is not currently known and is likely to be patient‑specific based on efficacy and toxicity. In the present study, 52 patients with advanced TNBC received OXA and S‑1 chemotherapy. The efficacy and toxicity were observed. The results showed that the median number of regimens was 4 (range 2‑6). The therapeutic efficacy was evaluated in all patients. The complete response, partial response, overall response and disease control rates were 3.8, 30.8, 34.6 and 69.2%, respectively. Four patients were lost to follow‑up, and the median follow‑up time was 13.7 months. The median progression‑free survival time was 6.7 months [95% confidence interval (CI), 4.5‑9.0] and the median overall survival (OS) time was 13.3 months (95% CI, 9.1‑17.5). From the subgroup analysis, it was found that the median OS time of patients with stage IV disease and ≥2 metastases was significantly shorter than that of patients with stage IIIC disease and only 1 metastasis [11.3 vs. 22.7 months, P=0.010 (stage IV vs. stage IIC); 11.3 vs. 15.7 months, P=0.048 (≥2 vs. 1 metastasis)]. The main grade 3/4 toxic effects were neutropenia (11.5%), nausea (7.7%) and nerve toxicity (3.8%). The other toxic effects were mainly of grades 1‑2 and included diarrhea, liver dysfunction, stomatitis, anemia and hand‑foot syndrome. In conclusion, OXA combined with S‑1 is an effective and tolerable regimen for the treatment of patients with advanced TNBC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Vrdoljak E, Miše BP, Lukić B, et al: Long-lasting control of triple-negative metastatic breast cancer with the novel drug combination ixabepilone and capecitabine - case report. Onkologie. 33:53–56. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Rakha EA and Ellis IO: Triple-negative/basal-like breast cancer: Review. Pathology. 41:40–47. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Fei F, Chen C, Xue J, et al: Efficacy and safety of docetaxel combined with oxaliplatin as a neoadjuvant chemotherapy regimen for Chinese triple-negative local advanced breast cancer patients. A prospective, open, and unicentric Phase II clinical trial. Am J Clin Oncol. 36:545–551. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Oakman C, Viale G and Di Leo A: Management of triple negative breast cancer. Breast. 19:312–321. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Tan DS, Marchió C, Jones RL, et al: Triple negative breast cancer: Molecular profiling and prognostic impact in adjuvant anthracycline-treated patients. Breast Cancer Res Treat. 111:27–44. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Liu M, Mo QG, Wei CY, et al: Platinum-based chemotherapy in triple-negative breast cancer: A meta-analysis. Oncol Lett. 5:983–991. 2013.PubMed/NCBI

7 

Sumpter K, Harper-Wynne C, Cunningham D, et al: Report of two protocol planned interim analyses in a randomised multicentre phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer receiving ECF. Br J Cancer. 92:1976–1983. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Huang J, Cao Y, Wu L, et al: S-1-based therapy versus 5-FU-based therapy in advanced gastric cancer: A meta-analysis. Med Oncol. 28:1004–1011. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Hara F, Kiyoto S, Takahashi M, et al: Efficacy and safety of S-1 in patients with metastatic breast cancer: Retrospective review in a single institution. Oncology. 79:273–277. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 92:205–216. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Trotti A, Colevas AD, Setser A, et al: CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 13:176–181. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Perou CM, Sørlie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Rastelli F, Biancanelli S, Falzetta A, et al: Triple-negative breast cancer: Current state of the art. Tumori. 96:875–888. 2010.PubMed/NCBI

14 

Turner N, Tutt A and Ashworth A: Hallmarks of ‘BRCAness’ in sporadic cancers. Nat Rev Cancer. 4:814–819. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Fornier M and Fumoleau P: The paradox of triple negative breast cancer: Novel approaches to treatment. Breast J. 18:41–51. 2012. View Article : Google Scholar : PubMed/NCBI

16 

De Laurentiis M, Cianniello D, Caputo R, et al: Treatment of triple negative breast cancer (TNBC): Current options and future perspectives. Cancer Treat Rev. 36:(Suppl 3). S80–S86. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Rakha EA, El-Sayed ME, Green AR, et al: Prognostic markers in triple-negative breast cancer. Cancer. 109:25–32. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Rhee J, Han SW, Oh DY, et al: The clinicopathologic characteristics and prognostic significance of triple-negativity in node-negative breast cancer. BMC Cancer. 8:3072008. View Article : Google Scholar : PubMed/NCBI

19 

Geisler S, Lønning PE, Aas T, et al: Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res. 61:2505–2512. 2001.PubMed/NCBI

20 

Gadhikar MA, Sciuto MR, Alves MV, Pickering CR, Osman AA, Neskey DM, Zhao M, Fitzgerald AL, Myers JN and Frederick MJ: Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53. Mol Cancer Ther. 12:1860–1873. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Dookeran KA, Dignam JJ, Ferrer K, et al: p53 as a marker of prognosis in African-American women with breast cancer. Ann Surg Oncol. 17:1398–1405. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Chae BJ, Bae JS, Lee A, et al: p53 as a specific prognostic factor in triple-negative breast cancer. Jpn J Clin Oncol. 39:217–224. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Hernandez-Aya LF, Chavez-Macgregor M, Lei X, et al: Nodal status and clinical outcomes in a large cohort of patients with triple-negative breast cancer. J Clin Oncol. 29:2628–2634. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Lower EE, Glass E, Blau R and Harman S: HER-2/neu expression in primary and metastatic breast cancer. Breast Cancer Res Treat. 113:301–306. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Lower EE, Glass EL, Bradley DA, et al: Impact of metastatic estrogen receptor and progesterone receptor status on survival. Breast Cancer Res Treat. 90:65–70. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Lippman ME, Allegra JC, Thompson EB, et al: The relation between estrogen receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N Engl J Med. 298:1223–1228. 1978. View Article : Google Scholar : PubMed/NCBI

27 

Keam B, Im SA, Kim HJ, et al: Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: Paradoxical features of the triple negative breast cancer. BMC Cancer. 7:2032007. View Article : Google Scholar : PubMed/NCBI

28 

Roy V, Pockaj BA, Allred JB, et al: A Phase II trial of docetaxel and carboplatin administered every 2 weeks as preoperative therapy for stage II or III breast cancer: NCCTG study N0338. Am J Clin Oncol. 36:540–544. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Villarreal-Garza C, Khalaf D, Bouganim N, et al: Platinum-based chemotherapy in triple-negative advanced breast cancer. Breast Cancer Res Treat. 146:567–572. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Sirohi B, Arnedos M, Popat S, et al: Platinum-based chemotherapy in triple-negative breast cancer. Ann Oncol. 19:1847–1852. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Virag P, Perde-Schrepler M, Fischer-Fodor E, et al: Superior cytotoxicity and DNA cross-link induction by oxaliplatin versus cisplatin at lower cellular uptake in colorectal cancer cell lines. Anticancer Drugs. 23:1032–1038. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Dunn TA, Schmoll HJ, Grünwald V, Bokemeyer C and Casper J: Comparative cytotoxicity of oxaliplatin and cisplatin in non-seminomatous germ cell lines. Invest New Drugs. 15:109–114. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Kang M, Jiang H, Wang S, et al: Efficacy of docetaxel combined with oxaliplatin by different administration routes in treatment of anthracycline-resistant metastatic breast cancer. Zhong Guo Zhong Liu Lin Chuang Yu Kang Fu. 12:527–529. 2005.(In Chinese).

34 

Thuss-Patience PC, von Minckwitz G, Kretzschmar A, et al: Oxaliplatin and 5-fluorouracil for heavily pretreated metastatic breast cancer: A preliminary phase II study. Anticancer Drugs. 14:549–553. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Miura K, Kinouchi M, Ishida K, et al: 5-fu metabolism in cancer and orally-administrable 5-fu drugs. Cancers (Basel). 2:1717–1730. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Lee JL, Kang YK, Kang HJ, et al: A randomised multicentre phase II trial of capecitabine vs S-1 as first-line treatment in elderly patients with metastatic or recurrent unresectable gastric cancer. Br J Cancer. 99:584–590. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Lv H, Yan M, Zhang M, et al: Efficacy of capecitabine-based combination therapy and single-agent capecitabine maintenance therapy in patients with metastatic breast cancer. Chin J Cancer Res. 26:692–697. 2014.PubMed/NCBI

38 

Gelmon K, Chan A and Harbeck N: The role of capecitabine in first-line treatment for patients with metastatic breast cancer. Oncologist. 11:(Suppl 1). 42–51. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Shirasaka T, Tsukuda M, Inuyama Y and Taguchi T: New oral anticancer drug, TS-1 (S-1) - from bench to clinic. Gan To Kagaku Ryoho. 28:855–864. 2001.(In Japanese). PubMed/NCBI

40 

Koizumi W, Narahara H, Hara T, et al: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): A phase III trial. Lancet Oncol. 9:215–221. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Boku N: Gastrointestinal Oncology Study Group of Japan Clinical Oncology Group: Chemotherapy for metastatic disease: Review from JCOG trials. Int J Clin Oncol. 13:196–200. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Shien T, Shimizu C, Akashi-Tanaka S, et al: Clinical efficacy of S-1 in pretreated metastatic breast cancer patients. Jpn J Clin Oncol. 38:172–175. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Yamamoto D, Iwase S, Yoshida H, et al: Efficacy of S-1 in patients with capecitabine-resistant breast cancer-Japan Breast Cancer Research Network (JBCRN) 04-1 trial. Anticancer Res. 30:3827–3831. 2010.PubMed/NCBI

44 

Fujii K, Kosaka J, Mouri Y, et al: Chemotherapy of a 2-week S-1 administration followed by 1-week rest for advanced and metastatic breast cancer. Gan To Kagaku Ryoho. 38:1467–1470. 2011.(In Japanese). PubMed/NCBI

45 

Saeki T: Clinical benefit of S-1 in metastatic breast cancer. Gan To Kagaku Ryoho. 33:(Suppl 1). 202–206. 2006.(In Japanese). PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Xiao Y, Wei W, Guo JX, Liu YC, Huang XH, Zhang RX, Wu YJ and Zhou J: Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer. Exp Ther Med 10: 379-385, 2015.
APA
Liu, J., Xiao, Y., Wei, W., Guo, J., Liu, Y., Huang, X. ... Zhou, J. (2015). Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer. Experimental and Therapeutic Medicine, 10, 379-385. https://doi.org/10.3892/etm.2015.2489
MLA
Liu, J., Xiao, Y., Wei, W., Guo, J., Liu, Y., Huang, X., Zhang, R., Wu, Y., Zhou, J."Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer". Experimental and Therapeutic Medicine 10.1 (2015): 379-385.
Chicago
Liu, J., Xiao, Y., Wei, W., Guo, J., Liu, Y., Huang, X., Zhang, R., Wu, Y., Zhou, J."Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer". Experimental and Therapeutic Medicine 10, no. 1 (2015): 379-385. https://doi.org/10.3892/etm.2015.2489
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Xiao Y, Wei W, Guo JX, Liu YC, Huang XH, Zhang RX, Wu YJ and Zhou J: Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer. Exp Ther Med 10: 379-385, 2015.
APA
Liu, J., Xiao, Y., Wei, W., Guo, J., Liu, Y., Huang, X. ... Zhou, J. (2015). Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer. Experimental and Therapeutic Medicine, 10, 379-385. https://doi.org/10.3892/etm.2015.2489
MLA
Liu, J., Xiao, Y., Wei, W., Guo, J., Liu, Y., Huang, X., Zhang, R., Wu, Y., Zhou, J."Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer". Experimental and Therapeutic Medicine 10.1 (2015): 379-385.
Chicago
Liu, J., Xiao, Y., Wei, W., Guo, J., Liu, Y., Huang, X., Zhang, R., Wu, Y., Zhou, J."Clinical efficacy of administering oxaliplatin combined with S‑1 in the treatment of advanced triple‑negative breast cancer". Experimental and Therapeutic Medicine 10, no. 1 (2015): 379-385. https://doi.org/10.3892/etm.2015.2489
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team