Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2015 Volume 10 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 10 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy

  • Authors:
    • Xiao‑Bo Liu
    • Shu Pan
    • Xi‑Ge Yang
    • Zhi‑Wen Li
    • Qing‑Shan Sun
    • Zhuang Zhao
    • Hai‑Chun Ma
    • Cheng‑Ri Cui
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 181-186
    |
    Published online on: May 18, 2015
       https://doi.org/10.3892/etm.2015.2497
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In order to evaluate the effect of different doses of penehyclidine hydrochloride (penehyclidine) on heart rate (HR) and HR variability (HRV) in hysteroscopy, 180 patients (American Society of Anesthesiologists grade I‑II) were randomized equally to three groups: 0.5 mg penehyclidine and intravenous anesthesia (group I), 1.0 mg penehyclidine and intravenous anesthesia (group II) and saddle anesthesia combined with intravenous anesthesia (control group). HR and HRV, including total power (TP), low‑frequency power (LF), high‑frequency power (HF) and the LF to HF ratio (LF/HF), were recorded prior and subsequent to the induction of anesthesia (T0 and T1, respectively), following the start of surgery (T2) and following completion of surgery (T3). HR was lower at T2 than at T0 in the control patients, but no differences were observed in groups I and II. The HR at T2 was increased in group II compared with that in group I. TP in group II was significantly higher compared with that in group I at T2. At T1 and at T2, the LF and HF values were lower in group I than those in the controls. Patients in group II also had higher LF and HF at T2 than patients in group I. The HF was higher at T2 than that at T0 in the controls; however, the HF and LF did not change significantly within groups I and II. No significant differences were observed in the LF/HF ratio among the three groups. At a dose of 0.5 mg, penehyclidine stabilized HRV and did not alter the autonomic nervous modulation of HR. A penehyclidine dose of 1.0 mg may be superior to a dose of 0.5 mg in maintaining HR, but is less effective at balancing sympathetic and parasympathetic activity.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Xiao HT, Liao Z and Tong RS: Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 6:317–322. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Wang J, Ren Y, Zhu Y, et al: Effect of penehyclidine hydrochloride on the incidence of intra-operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia. Anaesthesia. 68:136–141. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Sun YJ, Song DD, Diao YG, Zhou J and Zhang TZ: Penehyclidine hydrochloride preserves the intestinal barrier function in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg. 146:179–185. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Patterson TA, Lipton JR, Bennett EL and Rosenzweig MR: Cholinergic receptor antagonists impair formation of intermediate-term memory in the chick. Behav Neural Biol. 54:63–74. 1990. View Article : Google Scholar : PubMed/NCBI

5 

Rossman AC: The physiology of the nicotinic acetylcholine receptor and its importance in the administration of anesthesia. AANA J. 79:433–440. 2011.PubMed/NCBI

6 

Harvey RD: Muscarinic receptor agonists and antagonists: effects on cardiovascular function. Handb Exp Pharmacol. 299–316. 2012.PubMed/NCBI

7 

Xiao HT, Liao Z, Meng XM, Yan XY, Chen SJ and Mo ZJ: Underlying mechanism of penehyclidine hydrochloride on isolated rat uterus. Fundam Clin Pharmacol. 23:419–421. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Z, Zhuang Y, Ouyang F, Zhang A, Zeng B and Gu M: Penehyclidine enhances the efficacy of tropisetron in prevention of PONV following gynecological laparoscopic surgery. J Anesth. 26:864–869. 2012. View Article : Google Scholar : PubMed/NCBI

9 

No authors listed. Heart rate variability. Standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 17:354–381. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC and Cohen RJ: Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science. 213:220–222. 1981. View Article : Google Scholar : PubMed/NCBI

11 

Di Iorio C, Cafiero T and Di Minno RM: The effects of pneumoperitoneum and head-up position on heart rate variability and QT interval dispersion during laparoscopic cholecystectomy. Minerva Anestesiol. 76:882–889. 2010.PubMed/NCBI

12 

Sugiura H, Chinushi M, Komura S, Hirono T and Aizawa Y: Heart rate variability is a useful parameter for evaluation of anticholinergic effect associated with inducibility of atrial fibrillation. Pacing Clin Electrophysiol. 28:1208–1214. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Fujiwara Y, Kurokawa S, Shibata Y, Asakura Y, Harado M and Komatsu T: Sympathovagal effects of spinal anaesthesia with intrathecal or intravenous fentanyl assessed by heart rate variability. Acta Anaesthesiol Scand. 53:476–482. 2009. View Article : Google Scholar : PubMed/NCBI

14 

No authors listed. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 93:1043–1065. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Banz VM, Jakob SM and Inderbitzin D: Review article: improving outcome after major surgery: pathophysiological considerations. Anesth Analg. 112:1147–1155. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Riznyk L, Fijałkowska M and Przesmycki K: Effects of thiopental and propofol on heart rate variability during fentanyl-based induction of general anesthesia. Pharmacol Rep. 57:128–134. 2005.PubMed/NCBI

17 

Lowe NK: The nature of labor pain. Am J Obstet Gynecol. 186:(5 Suppl Nature). S16–S24. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Alici G, Ozkan B, Acar G, et al: Evaluation of autonomic functions by heart rate variability after stenting in patients with carotid artery stenosis. Ann Noninvasive Electrocardiol. 18:126–129. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Sato R, Mizuno M, Miura T, et al: Angiotensin receptor blockers regulate the synchronization of circadian rhythms in heart rate and blood pressure. J Hypertens. 31:1233–1238. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Kaneshiro B, Grimes DA and Lopez LM: Pain management for tubal sterilization by hysteroscopy. Cochrane Database Syst Rev. 8:CD0092512012.PubMed/NCBI

21 

Griffis CA, Crabb Breen E, Compton P, et al: Acute painful stress and inflammatory mediator production. Neuroimmunomodulation. 20:127–133. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Florio P, Puzzutiello R, Filippeschi M, et al: Low-dose spinal anesthesia with hyperbaric bupivacaine with intrathecal fentanyl for operative hysteroscopy: a case series study. J Minim Invasive Gynecol. 19:107–112. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Cesur M, Alici HA, Erdem AF, Borekci B and Silbir F: Spinal anesthesia with sequential administration of plain and hyperbaric bupivacaine provides satisfactory analgesia with hemodynamic stability in cesarean section. Int J Obstet Anesth. 17:217–222. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Guo SB, Lin M and Hao ZB: The application of combination of spinal anesthesia and intraveous anesthesia in gynecological laproscopy. Zhong Guo Xian Dai Yao Wu Ying Yong. 3:902009.(In Chinese).

25 

Geffin B and Shapiro L: Sinus bradycardia and asystole during spinal and epidural anesthesia: a report of 13 cases. J Clin Anesth. 10:278–285. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Lesser JB, Sanborn KV, Valskys R and Kuroda M: Severe bradycardia during spinal and epidural anesthesia recorded by an anesthesia information management system. Anesthesiology. 99:859–866. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Malliani A, Pagani M, Lombardi F and Cerutti S: Cardiovascular neural regulation explored in the frequency domain. Circulation. 84:482–492. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Carr DB and Goudas LC: Acute pain. Lancet. 353:2051–2058. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Weissman A, Torkhov O, Weissman AI and Drugan A: The effects of meperidine and epidural analgesia in labor on maternal heart rate variability. Int J Obstet Anesth. 18:118–124. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Hanss R, Ohnesorge H, Kaufmann M, et al: Changes in heart rate variability may reflect sympatholysis during spinal anaesthesia. Acta Anaesthesiol Scand. 51:1297–1304. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Nakatsuka I, Ochiai R and Takeda J: Changes in heart rate variability in sevoflurane and nitrous oxide anesthesia: effects of respiration and depth of anesthesia. J Clin Anesth. 14:196–200. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Fujiwara Y, Sato Y, Shibata Y, Asakura Y, Nishiwaki K and Komatsu T: A greater decrease in blood pressure after spinal anaesthesia in patients with low entropy of the RR interval. Acta Anaesthesiol Scand. 51:1161–1165. 2007.PubMed/NCBI

33 

Haney MF and Wiklund U: Can heart rate variability become a screening tool for anesthesia-related hypotension? Acta Anaesthesiol Scand. 51:1289–1291. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Vettorello M, Colombo R, De Grandis CE, Costantini E and Raimondi F: Effect of fentanyl on heart rate variability during spontaneous and paced breathing in healthy volunteers. Acta Anaesthesiol Scand. 52:1064–1070. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Parati G, Mancia G, Di Rienzo M and Castiglioni P: Point: cardiovascular variability is/is not an index of autonomic control of circulation. J Appl Physiol (1985). 101:676–678; discussion 681–682. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu XB, Pan S, Yang XG, Li ZW, Sun QS, Zhao Z, Ma HC and Cui CR: Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy. Exp Ther Med 10: 181-186, 2015.
APA
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z. ... Cui, C. (2015). Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy. Experimental and Therapeutic Medicine, 10, 181-186. https://doi.org/10.3892/etm.2015.2497
MLA
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z., Ma, H., Cui, C."Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy". Experimental and Therapeutic Medicine 10.1 (2015): 181-186.
Chicago
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z., Ma, H., Cui, C."Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy". Experimental and Therapeutic Medicine 10, no. 1 (2015): 181-186. https://doi.org/10.3892/etm.2015.2497
Copy and paste a formatted citation
x
Spandidos Publications style
Liu XB, Pan S, Yang XG, Li ZW, Sun QS, Zhao Z, Ma HC and Cui CR: Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy. Exp Ther Med 10: 181-186, 2015.
APA
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z. ... Cui, C. (2015). Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy. Experimental and Therapeutic Medicine, 10, 181-186. https://doi.org/10.3892/etm.2015.2497
MLA
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z., Ma, H., Cui, C."Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy". Experimental and Therapeutic Medicine 10.1 (2015): 181-186.
Chicago
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z., Ma, H., Cui, C."Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy". Experimental and Therapeutic Medicine 10, no. 1 (2015): 181-186. https://doi.org/10.3892/etm.2015.2497
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team