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Article

Ultrastructural identification of telocytes in the muscularis of chicken ileum

  • Authors:
    • Ping Yang
    • Ya'an Liu
    • Nisar Ahmed
    • Shakeeb Ullah
    • Yi Liu
    • Qiusheng Chen
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China
  • Pages: 2325-2330
    |
    Published online on: October 30, 2015
       https://doi.org/10.3892/etm.2015.2841
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Abstract

Telocytes (TCs) are a specialized type of interstitial cells, characterized by a small cell body and long, thin processes, that have recently been identified in various cavitary and non‑cavitary organs of humans and laboratory mammals. Chickens present significant economical and scientific notability; however, ultrastructural identification of TCs remains unclear in birds. The aim of the present study was to describe electron microscopic evidence for the presence of TCs in the chicken gut. The ileum of healthy adult broiler chickens (n=10) was studied by transmission electron microscopy. TCs are characterized by several, long (tens to hundreds of µm) prolongations called telopodes (Tps). Tps, which are below the resolving power of light microscopy, display podomeres (thin segments of ≤0.2 µm) and podoms (dilations accommodating caveolae, mitochondria and endoplasmic reticulum). TCs were observed in every field, but were predominantly located in the myenteric plexus and the lamina propria. Tps frequently establish close spatial relationships with immune cells, blood vessels and nerve endings. On the basis of their distribution and morphology, it was hypothesized that the different locations of TCs may be associated with different roles.
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View References

1 

Faussone-Pellegrini MS and Thuneberg L: Guide to the identification of interstitial cells of Cajal. Microsc Res Tech. 47:248–266. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Daniel EE: Physiology and pathophysiology of the interstitial cell of Cajal: From bench to bedside. III. Interaction of interstitial cells of Cajal with neuromediators: an interim assessment. Am J Physiol Gastrointest Liver Physiol. 281:G1329–G1332. 2001.PubMed/NCBI

3 

Ward SM and Sanders KM: Interstitial cells of Cajal: Primary targets of enteric motor innervation. Anat Rec. 262:125–135. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Vanderwinden JM, Rumessen JJ, Bernex F, Schiffmann SN and Panthier JJ: Distribution and ultrastructure of interstitial cells of Cajal in the mouse colon, using antibodies to Kit and Kit(W-lacZ) mice. Cell Tissue Res. 302:155–170. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Farrugia G: Interstitial cells of Cajal in health and disease. Neurogastroenterol Motil. 20(Suppl 1): 54–63. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Mikkelsen HB: Interstitial cells of Cajal, macrophages and mast cells in the gut musculature: Morphology, distribution, spatial and possible functional interactions. J Cell Mol Med. 14:818–832. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Pieri L, Vannucchi MG and Faussone-Pellegrini MS: Histochemical and ultrastructural characteristics of an interstitial cell type different from ICC and resident in the muscle coat of human gut. J Cell Mol Med. 12:1944–1955. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Popescu LM and Faussone-Pellegrini MS: Telocytes - a case of serendipity: The winding way from interstitial cells of Cajal (ICC), via interstitial Cajal-like cells (ICLC) to telocytes. J Cell Mol Med. 14:729–740. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Nicolescu MI and Popescu LM: Telocytes in the interstitium of human exocrine pancreas: Ultrastructural evidence. Pancreas. 41:949–956. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Díaz-Flores L, Gutiérrez R, Sáez FJ, Díaz-Flores L Jr and Madrid JF: Telocytes in neuromuscular spindles. J Cell Mol Med. 17:457–465. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Milia AF, Ruffo M, Manetti M, Rosa I, Conte D, Fazi M, Messerini L and Ibba-Manneschi L: Telocytes in Crohn's disease. J Cell Mol Med. 17:1525–1536. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Manetti M, Rosa I, Messerini L, Guiducci S, Matucci-Cerinic M and Ibba-Manneschi L: A loss of telocytes accompanies fibrosis of multiple organs in systemic sclerosis. J Cell Mol Med. 18:253–262. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Li L, Lin M, Li L, Wang R, Zhang C, Qi G, Xu M, Rong R and Zhu T: Renal telocytes contribute to the repair of ischemically injured renal tubules. J Cell Mol Med. 18:1144–1156. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Li H, Zhang H, Yang L, Lu S and Ge J: Telocytes in mice bone marrow: Electron microscope evidence. J Cell Mol Med. 18:975–978. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Nicolescu MI and Manole CG: Telocytes and stem cells in regenerative medicine. FASEB J. 27:752–754. 2013.

16 

Chen X, Zheng Y, Manole CG, Wang X and Wang Q: Telocytes in human oesophagus. J Cell Mol Med. 17:1506–1512. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Popescu BO, Gherghiceanu M, Kostin S, Ceafalan L and Popescu LM: Telocytes in meninges and choroid plexus. Neurosci Lett. 516:265–269. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Popescu LM, Manole E, Serboiu CS, Manole CG, Suciu LC, Gherghiceanu M and Popescu BO: Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration. J Cell Mol Med. 15:1379–1392. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Popescu LM, Gherghiceanu M, Suciu LC, Manole CG and Hinescu ME: Telocytes and putative stem cells in the lungs: Electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res. 345:391–403. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Popescu LM, Manole CG, Gherghiceanu M, Ardelean A, Nicolescu MI, Hinescu ME and Kostin S: Telocytes in human epicardium. J Cell Mol Med. 14:2085–2093. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Kostin S: Myocardial telocytes: A specific new cellular entity. J Cell Mol Med. 14:1917–1921. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Bani D, Formigli L, Gherghiceanu M and Faussone-Pellegrini MS: Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J Cell Mol Med. 14:2531–2538. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Reynhout JK and Duke GE: Identification of interstitial cells of Cajal in the digestive tract of turkeys (Meleagris gallopavo). J Exp Zool. 283:426–440. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Yang P, Wang S, Gandahi J, Bian X, Wu L, Liu Y, Zhang L, Zhang Q and Chen Q: Ultrastructural identification of different subtypes of interstitial cells of Cajal in the chicken ileum. Poult Sci. 91:1936–1940. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Cantarero Carmona I, Luesma Bartolomé MJ and Junquera Escribano C: Identification of telocytes in the lamina propria of rat duodenum: transmission electron microscopy. J Cell Mol Med. 15:26–30. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Gherghiceanu M, Manole C and Popescu L: Telocytes in endocardium: Electron microscope evidence. J Cell Mol Med. 14:2330–2334. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Suciu L, Popescu LM, Gherghiceanu M, Regalia T, Nicolescu MI, Hinescu ME and Faussone-Pellegrini MS: Telocytes in human term placenta: Morphology and phenotype. Cells Tissues Organs. 192:325–339. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Ceafalan LM, Gherghiceanu M, Popescu L and Simionescu O: Telocytes in human skin-are they involved in skin regeneration? J Cell Mol Med. 16:1405–1420. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Kostin S and Popescu L: A distinct type of cell in myocardium: Interstitial Cajal-like cells (ICLCs). J Cell Mol Med. 13:295–308. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Cretoiu SM and Popescu LM: Telocytes revisited. Biomol concepts. 5:353–369. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Popescu LM and Nicolescu MI: Telocytes and stem cells. Resident Stem Cells and Regenerative Therapy. Goldenberg and de Carvalho Campos: (Elsevier, Amsterdam). 205–231. 2013. View Article : Google Scholar

32 

Ordonez P and Di Girolamo N: Limbal epithelial stem cells: Role of the niche microenvironment. Stem Cells. 30:100–107. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Scadden DT: The stem-cell niche as an entity of action. Nature. 441:1075–1079. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Faussone-Pellegrini MS and Popescu LM: Telocytes. Biomol Concepts. 2:481–489. 2011.PubMed/NCBI

35 

Koh BH, Roy R, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP, Hatton WJ, Ward SM, Sanders KM and Koh SD: Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells. J Cell Mol Med. 16:691–700. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Manole CG, Cismaşiu V, Gherghiceanu M and Popescu LM: Experimental acute myocardial infarction: Telocytes involvement in neo-angiogenesis. J Cell Mol Med. 15:2284–2296. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Zheng Y, Zhang M, Qian M, Wang L, Cismasiu VB, Bai C, Popescu LM and Wang X: Genetic comparison of mouse lung telocytes with mesenchymal stem cells and fibroblasts. J Cell Mol Med. 17:567–577. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Cretoiu SM, Cretoiu D, Marin A, Radu BM and Popescu LM: Telocytes: Ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium. Reproduction. 145:357–370. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Zheng Y, Cretoiu D, Yan G, Cretoiu SM, Popescu LM and Wang X: Comparative proteomic analysis of human lung telocytes with fibroblasts. J Cell Mol Med. 18:568–589. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Chen H and Wang X: Significance of bioinformatics in research of chronic obstructive pulmonary disease. J Clin Bioinforma. 1:352011. View Article : Google Scholar : PubMed/NCBI

41 

Wu D, Rice CM and Wang X: Cancer bioinformatics: A new approach to systems clinical medicine. BMC Bioinformatics. 13:712012. View Article : Google Scholar : PubMed/NCBI

42 

Gherghiceanu M and Popescu LM: Cardiac telocytes - their junctions and functional implications. Cell Tissue Res. 348:265–279. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang P, Liu Y, Ahmed N, Ullah S, Liu Y and Chen Q: Ultrastructural identification of telocytes in the muscularis of chicken ileum. Exp Ther Med 10: 2325-2330, 2015.
APA
Yang, P., Liu, Y., Ahmed, N., Ullah, S., Liu, Y., & Chen, Q. (2015). Ultrastructural identification of telocytes in the muscularis of chicken ileum. Experimental and Therapeutic Medicine, 10, 2325-2330. https://doi.org/10.3892/etm.2015.2841
MLA
Yang, P., Liu, Y., Ahmed, N., Ullah, S., Liu, Y., Chen, Q."Ultrastructural identification of telocytes in the muscularis of chicken ileum". Experimental and Therapeutic Medicine 10.6 (2015): 2325-2330.
Chicago
Yang, P., Liu, Y., Ahmed, N., Ullah, S., Liu, Y., Chen, Q."Ultrastructural identification of telocytes in the muscularis of chicken ileum". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2325-2330. https://doi.org/10.3892/etm.2015.2841
Copy and paste a formatted citation
x
Spandidos Publications style
Yang P, Liu Y, Ahmed N, Ullah S, Liu Y and Chen Q: Ultrastructural identification of telocytes in the muscularis of chicken ileum. Exp Ther Med 10: 2325-2330, 2015.
APA
Yang, P., Liu, Y., Ahmed, N., Ullah, S., Liu, Y., & Chen, Q. (2015). Ultrastructural identification of telocytes in the muscularis of chicken ileum. Experimental and Therapeutic Medicine, 10, 2325-2330. https://doi.org/10.3892/etm.2015.2841
MLA
Yang, P., Liu, Y., Ahmed, N., Ullah, S., Liu, Y., Chen, Q."Ultrastructural identification of telocytes in the muscularis of chicken ileum". Experimental and Therapeutic Medicine 10.6 (2015): 2325-2330.
Chicago
Yang, P., Liu, Y., Ahmed, N., Ullah, S., Liu, Y., Chen, Q."Ultrastructural identification of telocytes in the muscularis of chicken ileum". Experimental and Therapeutic Medicine 10, no. 6 (2015): 2325-2330. https://doi.org/10.3892/etm.2015.2841
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