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Pediatric obesity: Causes, symptoms, prevention and treatment (Review)

  • Authors:
    • Shumei Xu
    • Ying Xue
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 15-20
    |
    Published online on: November 11, 2015
       https://doi.org/10.3892/etm.2015.2853
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Abstract

Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21‑24% children and adolescents are overweight, and 16‑18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults. Obesity in children is a major health concern of the developed world. The National Health and Nutrition Examination Survey has reported that the prevalence of obesity is on the increase in all the pediatric age groups, in males and females, and in various ethnic and racial groups. Factors, such as eating habits, genetics, environment, metabolism, and lifestyle play an important role in the development of obesity. Over 90% of obesity cases are idiopathic and less than 10% are associated with genetic and hormonal causes. Obesity occurs when the body consumes more calories than it burns, through overeating and underexercising. The symptoms of obesity include breathing disorders, sleep apnea, chronic obstructive pulmonary disease, certain types of cancer such as prostate, bowel, breast and uterine, coronary heart disease, diabetes (type 2 in children), depression, liver and gallbladder problems, gastro‑esophageal reflux disease, high blood pressure, high cholesterol, stroke, and joint diseases such as osteoarthritis, pain in knees and lower back. Environmental, behavioral such as consumption of convenience foods, genetic, and family factors contribute to pediatric obesity. Obesity can be countered through lower calorie consumption, weight loss and diet programs, as well as increased physical activity. A number of endogenous molecules including leptin, hypothalamic melanocortin 4 receptor, and mitochondrial uncoupling proteins, are known to affect body weight. These molecules serve as potential targets for the pharmacological manipulation of obesity. Sibutramine and orlistat are primariliy used for the treatment of adult obesity, which produces modest weight loss, of 3‑8% compared to placebo. For children and obese adolescents, metformin is used in the case of insulin resistance and hyperinsulinemia. Octreotide is used for hypothalamic obesity. Bariatric surgery is performed for the treatment of severe childhood obesity. The causes, symptoms, prevention and treatment of pediatric obesity are described in the present review.
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View References

1 

Rome ES: Obesity prevention and treatment. Pediatr Rev. 32:363–372; quiz 373. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Childhood Obesity: Assessment, Prevention & Treatment. Childhood Obesity: Overview. 2015.

3 

Centers for Disease Control and Prevention: BMI guidelines with links to the growth charts. simplecdc.gov/nccdphp/dnpa/bmi/bmi-for-age.html

4 

Rettner R: Obesity: causes, complications and treatment. Live Sc. Feb 03–2015.

5 

Hill JO and Peters JC: Environmental contribution to the obesity epidemic. Science. 280:1371–1374. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Harris DM, Seymour J, Grummer-Strawn L, Cooper A, Collins B, Di Sogra L, Marshall A and Evans N: Let's move salad bars to schools: a public-private partnership to increase student fruit and vegetable consumption. Child Obes. 8:294–297. 2012.doi: 10.1089/chi.2012.0094. PubMed/NCBI

7 

Pulgarón ER: Childhood obesity: a review of increased risk for physical and psychological comorbidities. Clin Ther. 35:A18–A32. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Han JC, Lawlor DA and Kimm SYS: Childhood obesity. Lancet. 375:1737–1748. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Nowicka P and Flodmark CE: Family in pediatric obesity management: a literature review. Int J Pediatr Obes. 3(Suppl 1): 44–50. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Ebbeling CB, Pawlak DB and Ludwig DS: Childhood obesity: Public-health crisis, common sense cure. Lancet. 360:473–482. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Freedman DS, Dietz WH, Srinivasan SR and Berenson GS: The relation of overweight to cardiovascular risk factors among children and adolescents: The Bogalusa Heart Study. Pediatrics. 103:1175–1182. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Ford ES, Galuska DA, Gillespie C, Will JC, Giles WH and Dietz WH: C-reactive protein and body mass index in children: Findings from the Third National Health and Nutrition Examination Survey, 1988–1994. J Pediatr. 138:486–492. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Ferguson MA, Gutin B, Owens S, Litaker M, Tracy RP and Allison J: Fat distribution and hemostatic measures in obese children. Am J Clin Nutr. 67:1136–1140. 1998.PubMed/NCBI

14 

Tounian P, Aggoun Y, Dubern B, Varille V, Guy-Grand B, Sidi D, Girardet JP and Bonnet D: Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet. 358:1400–1404. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Srinivasan SR, Myers L and Berenson GS: Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes. 51:204–209. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Young-Hyman D, Schlundt DG, Herman L, De Luca F and Counts D: Evaluation of the insulin resistance syndrome in 5- to 10-year-old overweight/obese African-American children. Diabetes Care. 24:1359–1364. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Strong JP, Malcom GT, McMahan CA, Tracy RE, Newman WP III, Herderick EE and Cornhill JF: Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA. 281:727–735. 1999. View Article : Google Scholar : PubMed/NCBI

18 

McGill HC Jr, McMahan CA, Zieske AW, Tracy RE, Malcom GT, Herderick EE and Strong JP: Association of Coronary Heart Disease Risk Factors with microscopic qualities of coronary atherosclerosis in youth. Circulation. 102:374–379. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Gunnell DJ, Frankel SJ, Nanchahal K, Peters TJ and Davey Smith G: Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort. Am J Clin Nutr. 67:1111–1118. 1998.PubMed/NCBI

20 

Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, Beckles GL, Saaddine J, Gregg EW, Williamson DF, et al: Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr. 136:664–672. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, et al: Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med. 346:802–810. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Redline S, Tishler PV, Schluchter M, Aylor J, Clark K and Graham G: Risk factors for sleep-disordered breathing in children. associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med. 159:1527–1532. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Figueroa-Muñoz JI, Chinn S and Rona RJ: Association between obesity and asthma in 4–11 year old children in the UK. Thorax. 56:133–137. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Reybrouck T, Mertens L, Schepers D, Vinckx J and Gewillig M: Assessment of cardiorespiratory exercise function in obese children and adolescents by body mass-independent parameters. Eur J Appl Physiol Occup Physiol. 75:478–483. 1997. View Article : Google Scholar : PubMed/NCBI

25 

McNutt SW, Hu Y, Schreiber GB, Crawford PB, Obarzanek E and Mellin L: A longitudinal study of the dietary practices of black and white girls 9 and 10 years old at enrollment: the NHLBI Growth and Health Study. J Adolesc Health. 20:27–37. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Zoumas-Morse C, Rock CL, Sobo EJ and Neuhouser ML: Children's patterns of macronutrient intake and associations with restaurant and home eating. J Am Diet Assoc. 101:923–925. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Wiecha JL, Sobol AM, Peterson KE and Gortmaker SL: Household television access: associations with screen time, reading, and homework among youth. Ambul Pediatr. 1:244–251. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Gillman MW, Rifas-Shiman SL, Frazier AL, Rockett HR, Camargo CA Jr, Field AE, Berkey CS and Colditz GA: Family dinner and diet quality among older children and adolescents. Arch Fam Med. 9:235–240. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Sallis JF, Prochaska JJ and Taylor WC: A review of correlates of physical activity of children and adolescents. Med Sci Sports Exerc. 32:963–975. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Williams CL, Hayman LL, Daniels SR, Robinson TN, Steinberger J, Paridon S and Bazzarre T: Cardiovascular health in childhood: A statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 106:143–160. 2002. View Article : Google Scholar : PubMed/NCBI

31 

No authors listed: Methods for voluntary weight loss and control. NIH Technology Assessment Conference Panel. Consensus Development Conference. 30 March to 1 April 1992. Ann Intern Med. 119:764–770. 1993.

32 

Barlow SE and Dietz WH: Obesity evaluation and treatment: Expert Committee recommendations. The Maternal and Child Health Bureau, Health Resources and Services Administration and the Department of Health and Human Services. Pediatrics. 102:E291998. View Article : Google Scholar : PubMed/NCBI

33 

Glazer G: Long-term pharmacotherapy of obesity 2000: A review of efficacy and safety. Arch Intern Med. 161:1814–1824. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Freemark M and Bursey D: The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics. 107:E552001. View Article : Google Scholar : PubMed/NCBI

35 

Lustig RH, Rose SR, Burghen GA, Velasquez-Mieyer P, Broome DC, Smith K, Li H, Hudson MM, Heideman RL and Kun LE: Hypothalamic obesity caused by cranial insult in children: Altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr. 135:162–168. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Myers SE, Carrel AL, Whitman BY and Allen DB: Sustained benefit after 2 years of growth hormone on body composition, fat utilization, physical strength and agility, and growth in Prader-Willi syndrome. J Pediatr. 137:42–49. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA and O'Rahilly S: Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med. 341:879–884. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Yanovski JA: Intensive therapies for pediatric obesity. Pediatr Clin North Am. 48:1041–1053. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Strauss RS, Bradley LJ and Brolin RE: Gastric bypass surgery in adolescents with morbid obesity. J Pediatr. 138:499–504. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Hossain P, Kawar B and El Nahas M: Obesity and diabetes in the developing world - a growing challenge. N Engl J Med. 356:213–215. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Daniels SR, Arnett DK, Eckel RH, et al: Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment. Circulation. 111:1999–2002. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu S and Xue Y: Pediatric obesity: Causes, symptoms, prevention and treatment (Review). Exp Ther Med 11: 15-20, 2016.
APA
Xu, S., & Xue, Y. (2016). Pediatric obesity: Causes, symptoms, prevention and treatment (Review). Experimental and Therapeutic Medicine, 11, 15-20. https://doi.org/10.3892/etm.2015.2853
MLA
Xu, S., Xue, Y."Pediatric obesity: Causes, symptoms, prevention and treatment (Review)". Experimental and Therapeutic Medicine 11.1 (2016): 15-20.
Chicago
Xu, S., Xue, Y."Pediatric obesity: Causes, symptoms, prevention and treatment (Review)". Experimental and Therapeutic Medicine 11, no. 1 (2016): 15-20. https://doi.org/10.3892/etm.2015.2853
Copy and paste a formatted citation
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Spandidos Publications style
Xu S and Xue Y: Pediatric obesity: Causes, symptoms, prevention and treatment (Review). Exp Ther Med 11: 15-20, 2016.
APA
Xu, S., & Xue, Y. (2016). Pediatric obesity: Causes, symptoms, prevention and treatment (Review). Experimental and Therapeutic Medicine, 11, 15-20. https://doi.org/10.3892/etm.2015.2853
MLA
Xu, S., Xue, Y."Pediatric obesity: Causes, symptoms, prevention and treatment (Review)". Experimental and Therapeutic Medicine 11.1 (2016): 15-20.
Chicago
Xu, S., Xue, Y."Pediatric obesity: Causes, symptoms, prevention and treatment (Review)". Experimental and Therapeutic Medicine 11, no. 1 (2016): 15-20. https://doi.org/10.3892/etm.2015.2853
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