Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome

Pan,Zhe; Zhuang,Xianghua; Li,Xiaobo; Huang,Shaoyi; Zhang,Liang; Lou,Fuchen; Chen,Shihong; Ni,Yihong

doi:10.3892/etm.2016.2997

Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome

Authors:
- Zhe Pan
- Xianghua Zhuang
- Xiaobo Li
- Shaoyi Huang
- Liang Zhang
- Fuchen Lou
- Shihong Chen
- Yihong Ni
View Affiliations

Affiliations: Department of Endocrinology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
Published online on: January 15, 2016 https://doi.org/10.3892/etm.2016.2997
Pages: 841-845
Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Obstructive sleep apnea‑hypopnea syndrome (OSAHS) is a commonly‑diagnosed chronic sleep disorder. It is considered to be an important independent risk factor in the development of insulin resistance (IR). Patients with OSAHS exhibit a variety of metabolic disorders, including obesity and metabolic syndrome. Visceral adipose tissue‑derived serpin (vaspin) is an adipokine that is considered to be a link between obesity and IR. The present study aimed to evaluate the levels of plasma vaspin in patients with OSAHS and examine their potential correlation with sleep characteristics. A total of 20 healthy male subjects and 42 male patients with OSAHS were selected, and patients were divided into mild (n=22) and severe (n=20) OSAHS groups. The 20 patients in the severe OSAHS group received nasal continuous positive airway pressure (nCPAP) treatment for 2 months. Venous blood samples were drawn from all patients in a fasting state prior to and subsequent to nCPAP treatment, which were used to measure the levels of biochemical indicators. The sleep parameters and serologic index changes were compared prior to and following treatment. The values of contractive pressure (SBP), neck circumference (NC), waist circumference (WC), waist‑to‑hip ratio (WHR), body mass index (BMI) and hip circumference (HC) in the two OSAHS groups were significantly increased compared with those in the control group. In addition, the levels of vaspin in OSAHS patients were markedly increased and vaspin was revealed to be positively associated with fasting blood sugar, fasting insulin, triglycerides, homeostasis model assessment‑IR, apnea‑hypopnea index (AHI), NC, WC, BMI and WHR (P<0.05). After 2 months of nCPAP treatment, the SBP and AHI were significantly reduced. In conclusion, vaspin may have an important role in OSAHS patients with IR and treatment using nCPAP may improve the condition of OSAHS patients.

View Figures

View References

1	Sunitha C and Aravindkumar S: Obstructive sleep apnea: Clinical and diagnostic features. Indian J Dent Res. 20:487–491. 2009. View Article : Google Scholar : PubMed/NCBI
2	Banno K and Kryger MH: Sleep apnea: Clinical investigations in humans. Sleep Med. 8:400–426. 2007. View Article : Google Scholar : PubMed/NCBI
3	Chen X, Niu X, Xiao Y, Dong J, Lu M and Kong W: Effect of continuous positive airway pressure on leptin levels in patients with obstructive sleep apnea: A meta-analysis. Otolaryngol Head Neck Surg. 152:610–618. 2015. View Article : Google Scholar : PubMed/NCBI
4	Riha RL, Gislasson T and Diefenbach K: The phenotype and genotype of adult obstructive sleep apnoea/hypopnoea syndrome. Eur Respir J. 33:646–655. 2009. View Article : Google Scholar : PubMed/NCBI
5	Tamada D, Otsuki M, Kashine S, Hirata A, Onodera T, Kitamura T and Shimomura I: Obstructive sleep apnea syndrome causes a pseudo-Cushing's state in Japanese obese patients with type 2 diabetes mellitus. Endocr J. 60:1289–1294. 2013. View Article : Google Scholar : PubMed/NCBI
6	Trujillo ME and Scherer PE: Adipose tissue-derived factors: Impact on health and disease. Endocr Rev. 27:762–778. 2006. View Article : Google Scholar : PubMed/NCBI
7	Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, et al: Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA. 102:10610–10615. 2005. View Article : Google Scholar : PubMed/NCBI
8	Li K, Li L, Yang M, Liu H, Liu D, Yang H, Boden G and Yang G: Short-term continuous subcutaneous insulin infusion decreases the plasma vaspin levels in patients with type 2 diabetes mellitus concomitant with improvement in insulin sensitivity. Eur J Endocrinol. 164:905–910. 2011. View Article : Google Scholar : PubMed/NCBI
9	Körner A, Neef M, Friebe D, Erbs S, Kratzsch J, Dittrich K, Blüher S, Kapellen TM, Kovacs P, Stumvoll M, et al: Vaspin is related to gender, puberty and deteriorating insulin sensitivity in children. Int J Obes. 35:578–86. 2011. View Article : Google Scholar
10	Quintas Dacal R, Novoa Tumbeiro M, Alves Pérez MT, Martínez Santalla ML, Fernández Acuña A and Velázquez Marcos P: Obstructive sleep apnea in normal weight patients: Characteristics and comparison with overweight and obese patients. Arch Bronconeumol. 49:513–517. 2013. View Article : Google Scholar : PubMed/NCBI
11	Kingsley GR and Getchell G: Direct ultramicro glucose oxidase method for determination of glucose in biologic fluids. Clin Chem. 6:466–475. 1960.PubMed/NCBI
12	Chokroverty S: Overview of sleep & sleep disorders. Indian J Med Res. 131:126–140. 2010.PubMed/NCBI
13	Iguchi A, Yamakage H, Tochiya M, Muranaka K, Sasaki Y, Kono S, Shimatsu A and Satoh-Asahara N: Effects of weight reduction therapy on obstructive sleep apnea syndrome and arterial stiffness in patients with obesity and metabolic syndrome. J Atheroscler Thromb. 20:807–820. 2013. View Article : Google Scholar : PubMed/NCBI
14	Kelishadi R, Nilforoushan N, Okhovat A, Amra B, Poursafa P and Rogha M: Effects of adenoidectomy on markers of endothelial function and inflammation in ormal-weight and overweight prepubescent children with sleep apnea. J Res Med Sci. 16(Suppl 1): S387–S394. 2011.PubMed/NCBI
15	Hida K, Wada J, Zhang H, Hiragushi K, Tsuchiyama Y, Shikata K and Makino H: Identification of genes specifically expressed in the accumulated visceral adipose tissue of OLETF rats. J Lipid Res. 41:1615–1622. 2000.PubMed/NCBI
16	Meslier N, Gagnadoux F, Giraud P, Person C, Ouksel H, Urban T and Racineux JL: Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur Respir J. 22:156–160. 2003. View Article : Google Scholar : PubMed/NCBI
17	Harwood HJ Jr.: The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology. 63:57–75. 2012. View Article : Google Scholar : PubMed/NCBI
18	Pérez PM, Moore-Carrasco R, González DR, Fuentes EQ and Palomo IG: Gene expression of adipose tissue, endothelial cells and platelets in subjects with metabolic syndrome (Review). Mol Med Rep. 5:1135–1140. 2012.PubMed/NCBI
19	Wada J: Vaspin: A novel serpin with insulin-sensitizing effects. Expert Opin Investig Drugs. 17:327–333. 2008. View Article : Google Scholar : PubMed/NCBI
20	Pedrosa RP, Krieger EM, Lorenzi-Filho G and Drager LF: Recent advances of the impact of obstructive sleep apnea on systemic hypertension. Arq Bras Cardiol. 97:e40–e47. 2011.(In English, Portuguese, Spanish). PubMed/NCBI
21	Douglas NJ and Martin SE: Arousals and the sleep apnea/hypopnea syndrome. Sleep. 19:S196–S197. 1996.PubMed/NCBI
22	Zamarrón C, Cuadrado Valdés L and Alvarez-Sala R: Pathophysiologic mechanisms of cardiovascular disease in obstructive sleep apnea syndrome. Pulm Med. 521087:2013.
23	Lurie A: Metabolic disorders associated with obstructive sleep apnea in adults. Adv Cardiol. 46:67–138. 2011. View Article : Google Scholar : PubMed/NCBI
24	Ruhle KH, Domanski U and Nilius G: Obstructive pressure peak: A new method for differentiation of obstructive and central apneas under auto-CPAP therapy. Sleep Breath. 17:111–115. 2013. View Article : Google Scholar : PubMed/NCBI
25	Oyama J, Yamamoto H, Maeda T, Ito A, Node K and Makino N: Continuous positive airway pressure therapy improves vascular dysfunction and decreases oxidative stress in patients with the metabolic syndrome and obstructive sleep apnea syndrome. Clin Cardiol. 35:231–236. 2012. View Article : Google Scholar : PubMed/NCBI