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Article Open Access

Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome

  • Authors:
    • Zhe Pan
    • Xianghua Zhuang
    • Xiaobo Li
    • Shaoyi Huang
    • Liang Zhang
    • Fuchen Lou
    • Shihong Chen
    • Yihong Ni
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 841-845
    |
    Published online on: January 15, 2016
       https://doi.org/10.3892/etm.2016.2997
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Abstract

Obstructive sleep apnea‑hypopnea syndrome (OSAHS) is a commonly‑diagnosed chronic sleep disorder. It is considered to be an important independent risk factor in the development of insulin resistance (IR). Patients with OSAHS exhibit a variety of metabolic disorders, including obesity and metabolic syndrome. Visceral adipose tissue‑derived serpin (vaspin) is an adipokine that is considered to be a link between obesity and IR. The present study aimed to evaluate the levels of plasma vaspin in patients with OSAHS and examine their potential correlation with sleep characteristics. A total of 20 healthy male subjects and 42 male patients with OSAHS were selected, and patients were divided into mild (n=22) and severe (n=20) OSAHS groups. The 20 patients in the severe OSAHS group received nasal continuous positive airway pressure (nCPAP) treatment for 2 months. Venous blood samples were drawn from all patients in a fasting state prior to and subsequent to nCPAP treatment, which were used to measure the levels of biochemical indicators. The sleep parameters and serologic index changes were compared prior to and following treatment. The values of contractive pressure (SBP), neck circumference (NC), waist circumference (WC), waist‑to‑hip ratio (WHR), body mass index (BMI) and hip circumference (HC) in the two OSAHS groups were significantly increased compared with those in the control group. In addition, the levels of vaspin in OSAHS patients were markedly increased and vaspin was revealed to be positively associated with fasting blood sugar, fasting insulin, triglycerides, homeostasis model assessment‑IR, apnea‑hypopnea index (AHI), NC, WC, BMI and WHR (P<0.05). After 2 months of nCPAP treatment, the SBP and AHI were significantly reduced. In conclusion, vaspin may have an important role in OSAHS patients with IR and treatment using nCPAP may improve the condition of OSAHS patients.
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Copy and paste a formatted citation
Spandidos Publications style
Pan Z, Zhuang X, Li X, Huang S, Zhang L, Lou F, Chen S and Ni Y: Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome. Exp Ther Med 11: 841-845, 2016.
APA
Pan, Z., Zhuang, X., Li, X., Huang, S., Zhang, L., Lou, F. ... Ni, Y. (2016). Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome. Experimental and Therapeutic Medicine, 11, 841-845. https://doi.org/10.3892/etm.2016.2997
MLA
Pan, Z., Zhuang, X., Li, X., Huang, S., Zhang, L., Lou, F., Chen, S., Ni, Y."Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome". Experimental and Therapeutic Medicine 11.3 (2016): 841-845.
Chicago
Pan, Z., Zhuang, X., Li, X., Huang, S., Zhang, L., Lou, F., Chen, S., Ni, Y."Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome". Experimental and Therapeutic Medicine 11, no. 3 (2016): 841-845. https://doi.org/10.3892/etm.2016.2997
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Z, Zhuang X, Li X, Huang S, Zhang L, Lou F, Chen S and Ni Y: Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome. Exp Ther Med 11: 841-845, 2016.
APA
Pan, Z., Zhuang, X., Li, X., Huang, S., Zhang, L., Lou, F. ... Ni, Y. (2016). Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome. Experimental and Therapeutic Medicine, 11, 841-845. https://doi.org/10.3892/etm.2016.2997
MLA
Pan, Z., Zhuang, X., Li, X., Huang, S., Zhang, L., Lou, F., Chen, S., Ni, Y."Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome". Experimental and Therapeutic Medicine 11.3 (2016): 841-845.
Chicago
Pan, Z., Zhuang, X., Li, X., Huang, S., Zhang, L., Lou, F., Chen, S., Ni, Y."Significance of vaspin in obstructive sleep apnea‑hypopnea syndrome". Experimental and Therapeutic Medicine 11, no. 3 (2016): 841-845. https://doi.org/10.3892/etm.2016.2997
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