Preparation of a novel composite nanofiber gel‑encapsulated human placental extract through layer‑by‑layer self‑assembly

  • Authors:
    • Guohui Liu
    • Xi Chen
    • Wu Zhou
    • Shuhua Yang
    • Shunan Ye
    • Faqi Cao
    • Yi Liu
    • Yuan Xiong
  • View Affiliations

  • Published online on: February 17, 2016     https://doi.org/10.3892/etm.2016.3084
  • Pages: 1447-1452
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Abstract

Aqueous human placenta extract (HPE) has been previously used to treat chronic soft tissue ulcer; however, the optimal dosage of HPE has yet to be elucidated. The present study investigated a novel nanofiber gel composed through layer‑by‑layer (LbL) self‑assembly, in which HPE was encapsulated. IKVAV, RGD, RAD16 and FGL‑PA were screened and combined to produce an optimal vehicle nanofiber gel through LbL assembly. Subsequently, the aqueous HPE was encapsulated into this nanofiber at the appropriate concentration, and the morphology, particle size, drug loading efficacy, encapsulation rate, release efficiency and structure validation were detected. The encapsulation efficiency of all three HPE samples was >90%, the nanofiber gel exhibited a slow releasing profile, and the structure of HPE encapsulated in the nanofiber gel was unvaried. In conclusion, this type of novel composite nanocapsules may offer a promising delivery system for HPE.
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April-2016
Volume 11 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu G, Chen X, Zhou W, Yang S, Ye S, Cao F, Liu Y and Xiong Y: Preparation of a novel composite nanofiber gel‑encapsulated human placental extract through layer‑by‑layer self‑assembly. Exp Ther Med 11: 1447-1452, 2016
APA
Liu, G., Chen, X., Zhou, W., Yang, S., Ye, S., Cao, F. ... Xiong, Y. (2016). Preparation of a novel composite nanofiber gel‑encapsulated human placental extract through layer‑by‑layer self‑assembly. Experimental and Therapeutic Medicine, 11, 1447-1452. https://doi.org/10.3892/etm.2016.3084
MLA
Liu, G., Chen, X., Zhou, W., Yang, S., Ye, S., Cao, F., Liu, Y., Xiong, Y."Preparation of a novel composite nanofiber gel‑encapsulated human placental extract through layer‑by‑layer self‑assembly". Experimental and Therapeutic Medicine 11.4 (2016): 1447-1452.
Chicago
Liu, G., Chen, X., Zhou, W., Yang, S., Ye, S., Cao, F., Liu, Y., Xiong, Y."Preparation of a novel composite nanofiber gel‑encapsulated human placental extract through layer‑by‑layer self‑assembly". Experimental and Therapeutic Medicine 11, no. 4 (2016): 1447-1452. https://doi.org/10.3892/etm.2016.3084