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Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma

  • Authors:
    • Hong Yan Chen
    • Wei Yan Liu
    • Hui Zhu
    • Dao Wen Jiang
    • Dong Hua Wang
    • Yongqi Chen
    • Weihua Li
    • Gaofeng Pan
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound in Medicine, Minhang Central Hospital, Shanghai 201199, P.R. China, Department of Surgery, Minhang Central Hospital, Shanghai 201199, P.R. China, Department of Pathology, Minhang Central Hospital, Shanghai 201199, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1555-1562
    |
    Published online on: February 19, 2016
       https://doi.org/10.3892/etm.2016.3094
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Abstract

The aim of the present study was to explore the value and characteristics of contrast‑enhanced ultrasound (CEUS) in the diagnosis of papillary thyroid microcarcinoma (PTMC). By analyzing CEUS information of 130 nodules obtained from 106 patients with PTMC, who had been diagnosed by surgery and pathological analysis, CEUS characteristics of PTMC nodules were concluded. Based on the results, the PTMC nodules were divided into three groups as follows: 32 nodules (24.62%) were found to be enhanced earlier than the surrounding normal thyroid tissue, 95 nodules (73.08%) were enhanced at the same time as the normal thyroid tissue and 3 nodules (2.30%) were enhanced later than the normal thyroid tissue. The results also demonstrated that the peak enhancement intensity of the 130 nodules was lower compared with the irregular intensity of the normal parenchyma in corresponding thyroids, and that PTMC enhancement washed out faster than in normal thyroid parenchyma. In conclusion, the PTMC characteristics that CEUS can detect may improve the diagnostic accuracy and provide valuable information for the treatment of the disease.
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1 

Colonna M, Uhry Z, Guizard AV, Delafosse P, Schvartz C, Belot A and Grosclaude P: FRANCIM network: Recent trends in incidence, geographical distribution, and survival of papillary thyroid cancer in France. Cancer Epidemiol. 39:511–518. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Roti E, de Gli Uberti EC, Bondanelli M and Braverman LE: Thyroid papillary microcarcinoma: A descriptive and meta-analysis study. Eur J Endocrinol. 159:659–673. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Hughes DT, Haymart MR, Miller BS, Gauger PG and Doherty GM: The most commonly occurring papillary thyroid cancer in the United States is now a microcarcinoma in a patient older than 45 years. Thyroid. 21:231–236. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K and Miyauchi A: Papillary microcarcinoma of the thyroid: How should it be treated? World J Surg. 28:1115–1121. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Pelizzo MR, Boschin IM, Toniato A, Piotto A, Bernante P, Pagetta C, Rampin L and Rubello D: Papillary thyroid microcarcinoma (PTMC): Prognostic factors, management and outcome in 403 patients. Eur J Surg Oncol. 32:1144–1148. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Smith-Bindman R, Lebda P, Feldstein VA, Sellami D, Goldstein RB, Brasic N, Jin C and Kornak J: Risk of thyroid cancer based on thyroid ultrasound imaging characteristicscs: Results of a population-based study. JAMA Intern Med. 173:1788–1796. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Pelizzo MR, Boschin IM, Toniato A, Pagetta C, Piotto A, Bernante P, Casara D, Pennelli G and Rubello D: Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): A mono-institutional 12-year experience. Nucl Med Commun. 25:547–552. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Pelizzo MR, Boschin IM, Toniato A, Pagetta C, Piotto A, Bernante P, Casara D, Pennelli G and Rubello D: Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): A mono-institutional 12-year experience. Nucl Med Commun. 25:547–552. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Cosgrove D: Microbubble enhancement of tumour neovascularity. Eur Radiol. 9(Suppl 3): S413–S414. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Mitchell JC and Parangi S: Angiogenesis in benign and malignant thyroid disease. Thyroid. 15:494–510. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Nemec U, Nemec SF, Novotny C, Weber M, Czerny C and Krestan CR: Quantitative evaluation of contrast-enhanced ultrasound after intravenous administration of a microbubble contrast agent for differentiation of benign and malignant thyroid nodules: Assessment of diagnostic accuracy. Eur Radiol. 22:1357–1365. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Agha A, Jung EM, Janke M, Hornung M, Georgieva M, Schlitt HJ, Schreyer AG, Strosczcynski C and Schleder S: Preoperative diagnosis of thyroid adenomas using high resolution contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc. 55:403–409. 2013.PubMed/NCBI

13 

Seo YL, Yoon DY, Baek S, Ku YJ, Rho YS, Chung EJ and Koh SH: Detection of neck recurrence in patients with differentiated thyroid cancer: comparison of ultrasound, contrast-enhanced CT and (18)F-FDG PET/CT using surgical pathology as a reference standard: (ultrasound vs. CT vs. (18)F-FDG PET/CT in recurrent thyroid cancer). Eur Radiol. 22:2246–2254. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Molinari F, Mantovani A, Deandrea M, Limone P, Garberoglio R and Suri JS: Characterization of single thyroid nodules by contrast-enhanced 3-D ultrasound. Ultrasound Med Biol. 36:1616–1625. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Deng J, Zhou P, Tian SM, Zhang L, Li JL and Qian Y: Comparison of diagnostic efficacy of contrast-enhanced ultrasound, acoustic radiation force impulse imaging, and their combined use in differentiating focal solid thyroid nodules. PLoS One. 9:e906742014. View Article : Google Scholar : PubMed/NCBI

16 

Acharya UR, Sree Vinitha S, Krishnan MM, Molinari F, Garberoglio R and Suri JS: Non-invasive automated 3D thyroid lesion classification in ultrasound: A class of ThyroScan™ systems. Ultrasonics. 52:508–520. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Hornung M, Jung EM, Georgieva M, Schlitt HJ, Stroszczynski C and Agha A: Detection of microvascularization of thyroid carcinomas using linear high resolution contrast-enhanced ultrasonography (CEUS). Clin Hemorheol Microcirc. 52:197–203. 2012.PubMed/NCBI

18 

Cantisani V, Consorti F, Guerrisi A, Guerrisi I, Ricci P, Di Segni M, Mancuso E, Scardella L, Milazzo F, D'Ambrosio F and Antonaci A: Prospective comparative evaluation of quantitative-elastosonography (Q-elastography) and contrast-enhanced ultrasound for the evaluation of thyroid nodules: Preliminary experience. Eur J Radio. 182:1892–1898. 2013. View Article : Google Scholar

19 

Giusti M, Orlandi D, Melle G, Massa B, Silvestri E, Minuto F and Turtulici G: Is there a real diagnostic impact of elastosonography and contrast-enhanced ultrasonography in the management of thyroid nodules? J Zhejiang Univ Sci B. 14:195–206. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Agha A, Hornung M, Rennert J, Uller W, Lighvani H, Schlitt HJ and Jung EM: Contrast-enhanced ultrasonography for localization of pathologic glands in patients with primary hyperparathyroidism. Surgery. 151:580–586. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Dietrich CF, Ignee A, Hocke M, Schreiber-Dietrich D and Greis C: Pitfalls and artefacts using contrast enhanced ultrasound. Z Gastroenterol. 49:350–356. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Friedrich-Rust M, Sperber A, Holzer K, Diener J, Grünwald F, Badenhoop K, Weber S, Kriener S, Herrmann E, Bechstein WO, Zeuzem S and Bojunga J: Real-time elastography and contrast-enhanced ultrasound for the assessment of thyroid nodules. Exp Clin Endocrinol Diabetes. 118:602–609. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen HY, Liu WY, Zhu H, Jiang DW, Wang DH, Chen Y, Li W and Pan G: Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma. Exp Ther Med 11: 1555-1562, 2016.
APA
Chen, H.Y., Liu, W.Y., Zhu, H., Jiang, D.W., Wang, D.H., Chen, Y. ... Pan, G. (2016). Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma. Experimental and Therapeutic Medicine, 11, 1555-1562. https://doi.org/10.3892/etm.2016.3094
MLA
Chen, H. Y., Liu, W. Y., Zhu, H., Jiang, D. W., Wang, D. H., Chen, Y., Li, W., Pan, G."Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 11.5 (2016): 1555-1562.
Chicago
Chen, H. Y., Liu, W. Y., Zhu, H., Jiang, D. W., Wang, D. H., Chen, Y., Li, W., Pan, G."Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1555-1562. https://doi.org/10.3892/etm.2016.3094
Copy and paste a formatted citation
x
Spandidos Publications style
Chen HY, Liu WY, Zhu H, Jiang DW, Wang DH, Chen Y, Li W and Pan G: Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma. Exp Ther Med 11: 1555-1562, 2016.
APA
Chen, H.Y., Liu, W.Y., Zhu, H., Jiang, D.W., Wang, D.H., Chen, Y. ... Pan, G. (2016). Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma. Experimental and Therapeutic Medicine, 11, 1555-1562. https://doi.org/10.3892/etm.2016.3094
MLA
Chen, H. Y., Liu, W. Y., Zhu, H., Jiang, D. W., Wang, D. H., Chen, Y., Li, W., Pan, G."Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 11.5 (2016): 1555-1562.
Chicago
Chen, H. Y., Liu, W. Y., Zhu, H., Jiang, D. W., Wang, D. H., Chen, Y., Li, W., Pan, G."Diagnostic value of contrast‑enhanced ultrasound in papillary thyroid microcarcinoma". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1555-1562. https://doi.org/10.3892/etm.2016.3094
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