Neonatal hypoglycemic brain injury is a cause of infantile spasms

  • Authors:
    • Guang Yang
    • Li‑Ping Zou
    • Jing Wang
    • Xiuyu Shi
    • Shuping Tian
    • Xiaofan Yang
    • Jun Ju
    • Hongxiang Yao
    • Yujie Liu
  • View Affiliations

  • Published online on: February 25, 2016     https://doi.org/10.3892/etm.2016.3107
  • Pages: 2066-2070
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Abstract

Neonatal hypoglycemic brain injury is one of the causes of infantile spasms. In the present study, the clinical history and auxiliary examination results of 18 patients who developed infantile spasms several months after neonatal hypoglycemia were retrospectively analyzed. Among the 666 patients with infantile spasms admitted to two pediatric centers between January 2008 and October 2012, 18 patients developed infantile spasms after being diagnosed with neonatal hypoglycemia, defined as a whole blood glucose concentration of <2.6 mmol/l. These patients developed infantile spasms from between 2 and 10 months (mean, 4.9 months) following the diagnosis of neonatal hypoglycemia. All 18 patients had abnormal electroencephalographic findings with either classical or modified hypsarrhythmia. Upon examination using brain magnetic resonance imaging (MRI), 10 patients (55.6%) exhibited abnormalities. The MRI results principally showed a disproportional involvement of parietal and occipital cortices and sub‑cortical white matter lesions. In conclusion, the results of this study indicate that neonatal hypoglycemic brain injury is associated with the subsequent development of infantile spasms.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang G, Zou LP, Wang J, Shi X, Tian S, Yang X, Ju J, Yao H and Liu Y: Neonatal hypoglycemic brain injury is a cause of infantile spasms. Exp Ther Med 11: 2066-2070, 2016
APA
Yang, G., Zou, L., Wang, J., Shi, X., Tian, S., Yang, X. ... Liu, Y. (2016). Neonatal hypoglycemic brain injury is a cause of infantile spasms. Experimental and Therapeutic Medicine, 11, 2066-2070. https://doi.org/10.3892/etm.2016.3107
MLA
Yang, G., Zou, L., Wang, J., Shi, X., Tian, S., Yang, X., Ju, J., Yao, H., Liu, Y."Neonatal hypoglycemic brain injury is a cause of infantile spasms". Experimental and Therapeutic Medicine 11.5 (2016): 2066-2070.
Chicago
Yang, G., Zou, L., Wang, J., Shi, X., Tian, S., Yang, X., Ju, J., Yao, H., Liu, Y."Neonatal hypoglycemic brain injury is a cause of infantile spasms". Experimental and Therapeutic Medicine 11, no. 5 (2016): 2066-2070. https://doi.org/10.3892/etm.2016.3107