Allicin inhibits transient outward potassium currents in mouse ventricular myocytes

  • Authors:
    • Hong Cao
    • Congxin Huang
    • Xin Wang
  • View Affiliations

  • Published online on: February 29, 2016     https://doi.org/10.3892/etm.2016.3116
  • Pages: 1896-1900
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Abstract

Allicin is the active constituent of garlic, a widely used spice and food. The remedial properties of garlic have also been extensively researched and it has been demonstrated that allicin is able to inhibit the transient outward potassium current (Ito) in atrial myocytes. However, the direct effect of allicin on Ito in ventricular myocytes has yet to be elucidated. In the present study, the effects of allicin on Ito in ventricular myocytes isolated from mice were investigated, using the whole-cell patch recording technique. The results revealed that Ito current was not significantly suppressed by allicin in the low‑dose group (10 µmol/l; P>0.05). However, Ito was significantly inhibited by higher doses of allicin (30, 100 and 300 µmol/l; P<0.05 vs. control; n=6) in a concentration-dependent manner (IC50=41.6 µmol/l). In addition, a high concentration of allicin (≥100 µmol/l) was able to accelerate the voltage‑dependent inactivation of Ito in mouse ventricular myocytes. In conclusion, the present study revealed that allicin inhibited the Ito in mouse ventricular myocytes, which may be the mechanism through which allicin exerts its antiarrhythmic effect.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cao H, Huang C and Wang X: Allicin inhibits transient outward potassium currents in mouse ventricular myocytes. Exp Ther Med 11: 1896-1900, 2016
APA
Cao, H., Huang, C., & Wang, X. (2016). Allicin inhibits transient outward potassium currents in mouse ventricular myocytes. Experimental and Therapeutic Medicine, 11, 1896-1900. https://doi.org/10.3892/etm.2016.3116
MLA
Cao, H., Huang, C., Wang, X."Allicin inhibits transient outward potassium currents in mouse ventricular myocytes". Experimental and Therapeutic Medicine 11.5 (2016): 1896-1900.
Chicago
Cao, H., Huang, C., Wang, X."Allicin inhibits transient outward potassium currents in mouse ventricular myocytes". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1896-1900. https://doi.org/10.3892/etm.2016.3116