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Article

Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis

  • Authors:
    • Minoru Tomizawa
    • Fuminobu Shinozaki
    • Kazunori Fugo
    • Takafumi Sunaoshi
    • Eriko Sugiyama
    • Daisuke Kano
    • Misaki Shite
    • Ryouta Haga
    • Yoshiya Fukamizu
    • Satoshi Kagayama
    • Rumiko Hasegawa
    • Yoshinori Shirai
    • Yasufumi Motoyoshi
    • Takao Sugiyama
    • Shigenori Yamamoto
    • Takashi Kishimoto
    • Naoki Ishige
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chuo, Chiba 260‑8670, Japan, Department of Surgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Neurology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan
  • Pages: 1777-1780
    |
    Published online on: March 2, 2016
       https://doi.org/10.3892/etm.2016.3126
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Abstract

Differentiation between adenomyomatosis (ADM) and cancer of the gallbladder is necessary during diagnosis. Diffusion‑weighted whole body imaging with background body signal suppression (DWIBS) images are able to indicate cancer and inflammation. The fusion of a DWIBS with a T2 weighted image (DWIBS/T2) facilitates both functional and anatomical investigations. In the present study, patient records and images from patients with surgically confirmed ADM from April 2012 to October 2014 were analyzed retrospectively. The enrolled patients, including 6 men (64.2±13.1 years) and 4 women (57.3±12.4 years) were subjected to DWIBS/T2 during routine clinical practice. The diagnosis of ADM was based on magnetic resonance cholangiopancreatography, transabdominal ultrasonography, and endoscopic ultrasonography; ADM was diagnosed definitively when cystic lesions were observed, indicating the Rokitansky‑Aschoff sinus. A single patient was indicated to be positive by DWIBS/T2 imaging. The Rokitansky‑Aschoff sinus revealed a relatively high signal intensity; however, it was not as strong as that of the spleen. The signal intensity was also high on an apparent diffusion coefficient map, suggesting T2 shine‑through. The thickened wall displayed low signal intensity. The aforementioned results indicate that ADM may be negative upon DWIBS/T2 imaging; one false positive case was determined to be ADM, accompanied by chronic cholecystitis. The majority of patients with ADM displayed negative findings upon DWIBS/T2 imaging, and chronic cholecystitis may cause false positives.
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1 

Colquhoun J: Adenomyomatosis of the gall-bladder (intramural diverticulosis). Br J Radiol. 34:101–112. 1961. View Article : Google Scholar : PubMed/NCBI

2 

Williams I, Slavin G, Cox A, Simpson P and de Lacey G: Diverticular disease (adenomyomatosis) of the gallbladder: A radiological-pathological survey. Br J Radiol. 59:29–34. 1986. View Article : Google Scholar : PubMed/NCBI

3 

Kim JH, Jeong IH, Han JH, Kim JH, Hwang JC, Yoo BM, Kim JH, Kim MW and Kim WH: Clinical/pathological analysis of gallbladder adenomyomatosis; Type and pathogenesis. Hepatogastroenterology. 57:420–425. 2010.PubMed/NCBI

4 

Kim BS, Oh JY, Nam KJ, Cho JH, Kwon HJ, Yoon SK, Jeong JS and Noh MH: Focal thickening at the fundus of the gallbladder: Computed tomography differentiation of fundal type adenomyomatosis and localized chronic cholecystitis. Gut Liver. 8:219–223. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Imazu H, Mori N, Kanazawa K, Chiba M, Toyoizumi H, Torisu Y, Koyama S, Hino S, Ang TL and Tajiri H: Contrast-enhanced harmonic endoscopic ultrasonography in the differential diagnosis of gallbladder wall thickening. Dig Dis Sci. 59:1909–1916. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Joo I, Lee JY, Kim JH, Kim SJ, Kim MA, Han JK and Choi BI: Differentiation of adenomyomatosis of the gallbladder from early-stage, wall-thickening-type gallbladder cancer using high-resolution ultrasound. Eur Radiol. 23:730–738. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Yoshimitsu K, Irie H, Aibe H, Tajima T, Nishie A, Asayama Y, Matake K, Yamaguchi K, Matsuura S and Honda H: Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: A mimicker of adenomyomatosis. Eur Radiol. 15:229–233. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S and Van Cauteren M: Diffusion weighted whole body imaging with background body signal suppression (DWIBS): Technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med. 22:275–282. 2004.PubMed/NCBI

9 

Sehy JV, Ackerman JJ and Neil JJ: Apparent diffusion of water, ions and small molecules in the Xenopus oocyte is consistent with Brownian displacement. Magn Reson Med. 48:42–51. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Koike N, Cho A, Nasu K, Seto K, Nagaya S, Ohshima Y and Ohkohchi N: Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions. World J Gastroenterol. 15:5805–5812. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Kwee TC, Takahara T, Ochiai R, Nievelstein RA and Luijten PR: Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): Features and potential applications in oncology. Eur Radiol. 18:1937–1952. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Ohno Y, Koyama H, Onishi Y, Takenaka D, Nogami M, Yoshikawa T, Matsumoto S, Kotani Y and Sugimura K: Non-small cell lung cancer: Whole-body MR examination for M-stage assessment-utility for whole-body diffusion-weighted imaging compared with integrated FDG PET/CT. Radiology. 248:643–654. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Fischer MA, Nanz D, Hany T, Reiner CS, Stolzmann P, Donati OF, Breitenstein S, Schneider P, Weishaupt D, von Schulthess GK and Scheffel H: Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: A comparison with PET/CT. Eur Radiol. 21:246–255. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Sommer G, Wiese M, Winter L, Lenz C, Klarhöfer M, Forrer F, Lardinois D and Bremerich J: Preoperative staging of non-small-cell lung cancer: Comparison of whole-body diffusion-weighted magnetic resonance imaging and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography. Eur Radiol. 22:2859–2867. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Nechifor-Boilă IA, Bancu S, Buruian M, Charlot M, Decaussin-Petrucci M, Krauth JS, Nechifor-Boilă AC and Borda A: Diffusion weighted imaging with background body signal suppression/T2 image fusion in magnetic resonance mammography for breast cancer diagnosis. Chirurgia (Bucur). 108:199–205. 2013.PubMed/NCBI

16 

Stunell H, Buckley O, Geoghegan T, O'Brien J, Ward E and Torreggiani W: Imaging of adenomyomatosis of the gall bladder. J Med Imaging Radiat Oncol. 52:109–117. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Kim HJ, Park JH, Park DI, Cho YK, Sohn CI, Jeon WK, Kim BI and Choi SH: Clinical usefulness of endoscopic ultrasonography in the differential diagnosis of gallbladder wall thickening. Dig Dis Sci. 57:508–515. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Akatsu T, Aiura K, Shimazu M, Ueda M, Wakabayashi G, Tanabe M, Kawachi S and Kitajima M: Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps? Dig Dis Sci. 51:416–421. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Ching BH, Yeh BM, Westphalen AC, Joe BN, Qayyum A and Coakley FV: CT differentiation of adenomyomatosis and gallbladder cancer. AJR Am J Roentgenol. 189:62–66. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y, Miller FH, Chen ZE, Merrick L, Mortele KJ, Hoff FL, Hammond NA, Yaghmai V and Nikolaidis P: Diffusion-weighted MR imaging of solid and cystic lesions of the pancreas. Radiographics. 31:E47–E64. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Haradome H, Ichikawa T, Sou H, Yoshikawa T, Nakamura A, Araki T and Hachiya J: The pearl necklace sign: An imaging sign of adenomyomatosis of the gallbladder at MR cholangiopancreatography. Radiology. 227:80–88. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Lee NK, Kim S, Kim TU, Kim DU, Seo HI and Jeon TY: Diffusion-weighted MRI for differentiation of benign from malignant lesions in the gallbladder. Clin Radiol. 69:e78–e85. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Yoshioka M, Watanabe G, Uchinami H, Miyazawa H, Abe Y, Ishiyama K, Hashimoto M, Nakamura A and Yamamoto Y: Diffusion-weighted MRI for differential diagnosis in gallbladder lesions with special reference to ADC cut-off values. Hepatogastroenterology. 60:692–698. 2013.PubMed/NCBI

24 

Ogawa T, Horaguchi J, Fujita N, Noda Y, Kobayashi G, Ito K, Koshita S, Kanno Y, Masu K and Sugita R: High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: Differentiation between benignity and malignancy. J Gastroenterol. 47:1352–1360. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Padhani AR, Koh DM and Collins DJ: Whole-body diffusion-weighted MR imaging in cancer: Current status and research directions. Radiology. 261:700–718. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tomizawa M, Shinozaki F, Fugo K, Sunaoshi T, Sugiyama E, Kano D, Shite M, Haga R, Fukamizu Y, Kagayama S, Kagayama S, et al: Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis. Exp Ther Med 11: 1777-1780, 2016.
APA
Tomizawa, M., Shinozaki, F., Fugo, K., Sunaoshi, T., Sugiyama, E., Kano, D. ... Ishige, N. (2016). Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis. Experimental and Therapeutic Medicine, 11, 1777-1780. https://doi.org/10.3892/etm.2016.3126
MLA
Tomizawa, M., Shinozaki, F., Fugo, K., Sunaoshi, T., Sugiyama, E., Kano, D., Shite, M., Haga, R., Fukamizu, Y., Kagayama, S., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Kishimoto, T., Ishige, N."Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis". Experimental and Therapeutic Medicine 11.5 (2016): 1777-1780.
Chicago
Tomizawa, M., Shinozaki, F., Fugo, K., Sunaoshi, T., Sugiyama, E., Kano, D., Shite, M., Haga, R., Fukamizu, Y., Kagayama, S., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Kishimoto, T., Ishige, N."Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1777-1780. https://doi.org/10.3892/etm.2016.3126
Copy and paste a formatted citation
x
Spandidos Publications style
Tomizawa M, Shinozaki F, Fugo K, Sunaoshi T, Sugiyama E, Kano D, Shite M, Haga R, Fukamizu Y, Kagayama S, Kagayama S, et al: Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis. Exp Ther Med 11: 1777-1780, 2016.
APA
Tomizawa, M., Shinozaki, F., Fugo, K., Sunaoshi, T., Sugiyama, E., Kano, D. ... Ishige, N. (2016). Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis. Experimental and Therapeutic Medicine, 11, 1777-1780. https://doi.org/10.3892/etm.2016.3126
MLA
Tomizawa, M., Shinozaki, F., Fugo, K., Sunaoshi, T., Sugiyama, E., Kano, D., Shite, M., Haga, R., Fukamizu, Y., Kagayama, S., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Kishimoto, T., Ishige, N."Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis". Experimental and Therapeutic Medicine 11.5 (2016): 1777-1780.
Chicago
Tomizawa, M., Shinozaki, F., Fugo, K., Sunaoshi, T., Sugiyama, E., Kano, D., Shite, M., Haga, R., Fukamizu, Y., Kagayama, S., Hasegawa, R., Shirai, Y., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Kishimoto, T., Ishige, N."Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1777-1780. https://doi.org/10.3892/etm.2016.3126
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