Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis

Tomizawa,Minoru; Shinozaki,Fuminobu; Fugo,Kazunori; Sunaoshi,Takafumi; Sugiyama,Eriko; Kano,Daisuke; Shite,Misaki; Haga,Ryouta; Fukamizu,Yoshiya; Kagayama,Satoshi; Hasegawa,Rumiko; Shirai,Yoshinori; Motoyoshi,Yasufumi; Sugiyama,Takao; Yamamoto,Shigenori; Kishimoto,Takashi; Ishige,Naoki

doi:10.3892/etm.2016.3126

Negative signals for adenomyomatosis of the gallbladder upon diffusion‑weighted whole body imaging with background body signal suppression/T2‑weighted image fusion analysis

Authors:
- Minoru Tomizawa
- Fuminobu Shinozaki
- Kazunori Fugo
- Takafumi Sunaoshi
- Eriko Sugiyama
- Daisuke Kano
- Misaki Shite
- Ryouta Haga
- Yoshiya Fukamizu
- Satoshi Kagayama
- Rumiko Hasegawa
- Yoshinori Shirai
- Yasufumi Motoyoshi
- Takao Sugiyama
- Shigenori Yamamoto
- Takashi Kishimoto
- Naoki Ishige
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Affiliations: Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Radiology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chuo, Chiba 260‑8670, Japan, Department of Surgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Neurology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan, Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, Yotsukaido, Chiba 284‑0003, Japan
Published online on: March 2, 2016 https://doi.org/10.3892/etm.2016.3126
Pages: 1777-1780

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Abstract

Differentiation between adenomyomatosis (ADM) and cancer of the gallbladder is necessary during diagnosis. Diffusion‑weighted whole body imaging with background body signal suppression (DWIBS) images are able to indicate cancer and inflammation. The fusion of a DWIBS with a T2 weighted image (DWIBS/T2) facilitates both functional and anatomical investigations. In the present study, patient records and images from patients with surgically confirmed ADM from April 2012 to October 2014 were analyzed retrospectively. The enrolled patients, including 6 men (64.2±13.1 years) and 4 women (57.3±12.4 years) were subjected to DWIBS/T2 during routine clinical practice. The diagnosis of ADM was based on magnetic resonance cholangiopancreatography, transabdominal ultrasonography, and endoscopic ultrasonography; ADM was diagnosed definitively when cystic lesions were observed, indicating the Rokitansky‑Aschoff sinus. A single patient was indicated to be positive by DWIBS/T2 imaging. The Rokitansky‑Aschoff sinus revealed a relatively high signal intensity; however, it was not as strong as that of the spleen. The signal intensity was also high on an apparent diffusion coefficient map, suggesting T2 shine‑through. The thickened wall displayed low signal intensity. The aforementioned results indicate that ADM may be negative upon DWIBS/T2 imaging; one false positive case was determined to be ADM, accompanied by chronic cholecystitis. The majority of patients with ADM displayed negative findings upon DWIBS/T2 imaging, and chronic cholecystitis may cause false positives.

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