An unusual case of anaplastic lymphoma kinase‑positive large B‑cell lymphoma in an elderly patient: A case report and discussion

Xiong,Hanzhen; Liu,Shao‑Yan; Yang,Yue‑Xin; Tan,Xue‑Xian; Luo,Qiu‑Ping; Peng,Juan; Xiong,Zhong‑Tang; Chen,Hui; Chen,Juan; Li,Zhi; Jiang,Qing‑Ping

doi:10.3892/etm.2016.3129

May-2016 Volume 11 Issue 5

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May-2016 Volume 11 Issue 5

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Case Report

An unusual case of anaplastic lymphoma kinase‑positive large B‑cell lymphoma in an elderly patient: A case report and discussion

Authors:
- Hanzhen Xiong
- Shao‑Yan Liu
- Yue‑Xin Yang
- Xue‑Xian Tan
- Qiu‑Ping Luo
- Juan Peng
- Zhong‑Tang Xiong
- Hui Chen
- Juan Chen
- Zhi Li
- Qing‑Ping Jiang
View Affiliations / Copyright

Affiliations: Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China, Department of Pathology, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
Pages: 1799-1802
|
Published online on: March 2, 2016

https://doi.org/10.3892/etm.2016.3129
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Abstract

We present an unusual case of anaplastic lymphoma kinase (ALK)‑positive large B‑cell lymphoma, with rapid clinical progression, which occurred in a 90‑year‑old male patient. The patient presented with numerous enlarged lymph nodes in the neck and mediastinum. Histopathological analysis of a single lymph node detected diffuse large immunoblastic‑ or plasmablastic‑like tumor cells, which were strongly immunoreactive for ALK in a granular cytoplasmic distribution, but negative for the expression of CD20 and CD79a. In addition, polymerase chain reaction assays were unable to detect clonal rearrangements of the T cell receptor‑γ and immunoglobulin heavy chain genes in the tumor lesion, and in situ hybridization tested negative for infection with Epstein‑Barr virus. The patient underwent a single cycle of chemotherapy using the cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (E‑CHOP) regimen; however, the patient developed pleural effusions with respiratory distress, associated with clinical deterioration. The patient succumbed to the disease within 4 months of initial presentation. To the best of our knowledge, this is the eldest patient with this type of lymphoma to be reported in the literature.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

An unusual case of anaplastic lymphoma kinase‑positive large B‑cell lymphoma in an elderly patient: A case report and discussion

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