|
1
|
Carter D: New global survey shows an
increasing cancer burden. Am J Nurs. 114:172014. View Article : Google Scholar
|
|
2
|
Taha FM, Zeeneldin AA, Helal AM, Gaber AA,
Sallam YA, Ramadan H and Moneer MM: Prognostic value of serum
vascular endothelial growth factor in Egyptian females with
metastatic triple negative breast cancer. Clin Biochem.
42:1420–1426. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Coelho BA, Belo AV, Andrade SP, Amorim WC,
Uemura G and da Silva Filho AL: N-acetylglucosaminidase,
myeloperoxidase and vascular endothelial growth factor serum levels
in breast cancer patients. Biomed Pharmacother. 68:185–189. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Breidenbach M, Rein DT, Schöndorf T, Khan
KN, Herrmann I, Schmidt T, Reynolds PN, Vlodavsky I, Haviv YS and
Curiel DT: A new targeting approach for breast cancer gene therapy
using the heparanase promoter. Cancer Lett. 240:114–122. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Gnant M, Balic M, Petru E, Raunik W,
Singer CF, Steger GG, Watzke IM and Brodowicz T: Treatment of bone
metastases in patients with advanced breast cancer. Breast Care
(Basel). 7:92–98. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Coleman RE: Clinical features of
metastatic bone disease and skeletal morbidity. Clin Cancer Res.
12:6243s–6249s. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Sano M, Hayashi E, Murakami H, Kishimoto
H, Fukuzawa R and Nemoto N: Mcl-1, an anti-apoptotic Bcl-2 family
member, essentially overlaps with insulin-producing cells in
nesidioblastosis. Virchows Arch. 452:469–470. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Arnoult D, Parone P, Martinou JC,
Antonsson B, Estaquier J and Ameisen JC: Mitochondrial release of
apoptosis-inducing factor occurs downstream of cytochrome c release
in response to several proapoptotic stimuli. J Cell Biol.
159:923–929. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Fulda S and Debatin KM: Extrinsic versus
intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene.
25:4798–4811. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Debatin KM: Apoptosis pathways in cancer
and cancer therapy. Cancer Immunol Immunother. 53:153–159. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Algire C, Amrein L, Zakikhani M, Panasci L
and Pollak M: Metformin blocks the stimulative effect of a
high-energy diet on colon carcinoma growth in vivo and is
associated with reduced expression of fatty acid synthase. Endocr
Relat Cancer. 17:351–360. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhang ZJ, Zheng ZJ, Kan H, Song Y, Cui W,
Zhao G and Kip KE: Reduced risk of colorectal cancer with metformin
therapy in patients with type 2 diabetes: A meta-analysis. Diabetes
Care. 34:2323–2328. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Zhang ZJ, Zheng ZJ, Shi R, Su Q, Jiang Q
and Kip KE: Metformin for liver cancer prevention in patients with
type 2 diabetes: A systematic review and meta-analysis. J Clin
Endocrinol Metab. 97:2347–2353. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Emami Riedmaier A, Fisel P, Nies AT,
Schaeffeler E and Schwab M: Metformin and cancer: From the old
medicine cabinet to pharmacological pitfalls and prospects. Trends
Pharmacol Sci. 34:126–135. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Nair V, Pathi S, Jutooru I, Sreevalsan S,
Basha R, Abdelrahim M, Samudio I and Safe S: Metformin inhibits
pancreatic cancer cell and tumor growth and downregulates SP
transcription factors. Carcinogenesis. 34:2870–2879. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Bayraktar S, Hernadez-Aya LF, Lei X,
Meric-Bernstam F, Litton JK, Hsu L, Hortobagyi GN and
Gonzalez-Angulo AM: Effect of metformin on survival outcomes in
diabetic patients with triple receptor-negative breast cancer.
Cancer. 118:1202–1211. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
He X, Esteva FJ, Ensor J, Hortobagyi GN,
Lee MH and Yeung SC: Metformin and thiazolidinediones are
associated with improved breast cancer-specific survival of
diabetic women with HER2+ breast cancer. Ann Oncol. 23:1771–1780.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Hou G, Zhang S, Zhang X, Wang P, Hao X and
Zhang J: Clinical pathological characteristics and prognostic
analysis of 1,013 breast cancer patients with diabetes. Breast
Cancer Res Treat. 137:807–816. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Lega IC, Austin PC, Gruneir A, Goodwin PJ,
Rochon PA and Lipscombe LL: Association between metformin therapy
and mortality after breast cancer: A population-based study.
Diabetes Care. 36:3018–3026. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Shirakata Y and Koike K: Hepatitis B virus
X protein induces cell death by causing loss of mitochondrial
membrane potential. J Biol Chem. 278:22071–22078. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zamzami N, Marchetti P, Castedo M,
Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B and
Kroemer G: Sequential reduction of mitochondrial transmembrane
potential and generation of reactive oxygen species in early
programmed cell death. J Exp Med. 182:367–377. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Gottlieb E, Vander Heiden MG and Thompson
CB: Bcl-x (L) prevents the initial decrease in mitochondrial
membrane potential and subsequent reactive oxygen species
production during tumor necrosis factor alpha-induced apoptosis.
Mol Cell Biol. 20:5680–5689. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Bao B, Wang Z, Ali S, Ahmad A, Azmi AS,
Sarkar SH, Banerjee S, Kong D, Li Y, Thakur S and Sarkar FH:
Metformin inhibits cell proliferation, migration and invasion by
attenuating CSC function mediated by deregulating miRNAs in
pancreatic cancer cells. Cancer Prev Res (Phila). 5:355–364. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Chen TW, Liang YN, Feng D, Tao LY, Qi K,
Zhang HY, Wang HX, Lin QS and Kong H: Metformin inhibits
proliferation and promotes apoptosis of HER-2 positive breast
cancer cells by downregulating HSP90. J BUON. 18:51–56.
2013.PubMed/NCBI
|
|
25
|
Erices R, Bravo ML, Gonzalez P, Oliva B,
Racordon D, Garrido M, Ibañez C, Kato S, Brañes J, Pizarro J, et
al: Metformin at concentrations corresponding to the treatment of
diabetes, potentiates the cytotoxic effects of carboplatin in
cultures of ovarian cancer cells. Reprod Sci. 20:1433–1446. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Xiong Y, Lu QJ, Zhao J and Wu GY:
Metformin inhibits growth of hepatocellular carcinoma cells by
inducing apoptosis via mitochondrion-mediated pathway. Asian Pac J
Cancer Prev. 13:3275–3279. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Circu ML and Aw TY: Glutathione and
modulation of cell apoptosis. Biochim Biophys Acta. 1823:1767–1777.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Smith MA and Schnellman RG: Calpains,
mitochondria and apoptosis. Cardiovasc Res. 96:32–37. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Andersen JL and Kornbluth S: The tangled
circuitry of metabolism and apoptosis. Mol Cell. 49:399–410. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Petsophonsakul P, Pompimon W and
Banjerdpongchai R: Apoptosis induction in human leukemic
promyelocytic HL-60 and monocytic U937 cell lines by goniothalamin.
Asian Pac J Cancer Prev. 14:2885–2889. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Czabotar PE, Lessene G, Strasser A and
Adams JM: Control of apoptosis by the BCL-2 protein family:
Implications for physiology and therapy. Nat Rev Mol Cell Biol.
15:49–63. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
32
|
Cory S and Adams JM: The Bcl2 family:
Regulators of the cellular life-or-death switch. Nat Rev Cancer.
2:647–656. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
33
|
Green DR and Kroemer G: The
pathophysiology of mitochondrial cell death. Science. 305:626–629.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Rondelet B, Dewachter C, Kerbaul F, Kang
X, Fesler P, Brimioulle S, Naeije R and Dewachter L: Prolonged
overcirculation-induced pulmonary arterial hypertension as a cause
of right ventricular failure. Eur Heart J. 33:1017–1026. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
El-Mir MY, Nogueira V, Fontaine E, Avéret
N, Rigoulet M and Leverve X: Dimethylbiguanide inhibits cell
respiration via an indirect effect targeted on the respiratory
chain complex 1. J Biol Chem. 275:223–228. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Owen MR, Doran E and Halestrap AP:
Evidence that metformin exerts its anti-diabetic effects through
inhibition of complex 1 of the mitochondrial respiratory chain.
Biochem J. 348:607–614. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Behrend L, Henderson G and Zwacka RM:
Reactive oxygen species in oncogenic transformation. Biochem Soc
Trans. 31:1441–1444. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Simon HU, Haj-Yehia A and Levi-Schaffer F:
Role of reactive oxygen species (ROS) in apoptosis induction.
Apoptosis. 5:415–418. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Aldea MD, Petrushev B, Soritau Q,
Tomuleasa CI, Berindan-Neagoe I, Filip AG, Chereches G, Cenariu M,
Craciun L, Tatomir C, et al: Metformin plus sorafenib high impacts
temozolomide resistant glioblastoma stem-like cells. J Buon.
19:502–511. 2014.PubMed/NCBI
|
|
40
|
Haugrud AB, Zhuang Y, Coppock JD and
Miskimins WK: Dichloroacetate enhance apoptotic cell death via
oxidative damage and attenuates lactate production in
metformin-treated breast cancer cells. Breast Cancer Res Treat.
147:539–550. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kim EH, Kim MS, Cho CK, Jung WG, Jeong YK
and Jeong JH: Low and high linear energy transfer radiation
sensitization of HCC cells by metformin. J Radiat Res. 55:432–442.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Wang X: The expanding role of mitochondria
in apoptosis. Genes Dev. 15:2922–2933. 2001.PubMed/NCBI
|
|
43
|
Ibrahim MY, Hashim NM, Mohan S, Abdulla
MA, Kamalidehghan B, Ghaderian M, Dehghan F, Ali LZ, Arbab IA,
Yahayu M, et al: α-Mangostin from Cratoxylum arborescens
demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and
Hsp70 protein modulation in vitro and tumor reduction in vivo. Drug
Des Devel Ther. 8:1629–1647. 2014. View Article : Google Scholar : PubMed/NCBI
|
