Novel therapy for anti-glomerular basement membrane disease with IgA nephropathy: A case report

  • Authors:
    • Dechao Xu
    • Jianxiang Wu
    • Jun Wu
    • Chenggang Xu
    • Yuqiang Zhang
    • Changlin Mei
    • Xiang Gao
  • View Affiliations

  • Published online on: March 11, 2016     https://doi.org/10.3892/etm.2016.3149
  • Pages: 1889-1892
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Abstract

Anti-glomerular basement membrane (GBM) disease is characterized by circulating anti-GBM antibodies and deposition of these antibodies in the renal GBM. Renal involvement in anti‑GBM is more severe when compared with other types of immune-mediated glomerulonephritis, and the majority of patients manifest progressive renal failure, leading to end‑stage renal disease. In a limited number of cases, anti‑GBM disease has been shown to be accompanied with other immune‑mediated glomerulonephritis. The present study reported the case of a 50‑year‑old female patient presenting with rapidly progressive glomerulonephritis, who was diagnosed with anti‑GBM disease with IgA nephropathy. The patient achieved a relatively good therapeutic outcome with administration of corticosteroids plus mycophenolate mofetil (MMF), which may prove to be a novel treatment option for this rare disease; however, the exact underlying mechanism requires further in‑depth investigation.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xu D, Wu J, Wu J, Xu C, Zhang Y, Mei C and Gao X: Novel therapy for anti-glomerular basement membrane disease with IgA nephropathy: A case report. Exp Ther Med 11: 1889-1892, 2016
APA
Xu, D., Wu, J., Wu, J., Xu, C., Zhang, Y., Mei, C., & Gao, X. (2016). Novel therapy for anti-glomerular basement membrane disease with IgA nephropathy: A case report. Experimental and Therapeutic Medicine, 11, 1889-1892. https://doi.org/10.3892/etm.2016.3149
MLA
Xu, D., Wu, J., Wu, J., Xu, C., Zhang, Y., Mei, C., Gao, X."Novel therapy for anti-glomerular basement membrane disease with IgA nephropathy: A case report". Experimental and Therapeutic Medicine 11.5 (2016): 1889-1892.
Chicago
Xu, D., Wu, J., Wu, J., Xu, C., Zhang, Y., Mei, C., Gao, X."Novel therapy for anti-glomerular basement membrane disease with IgA nephropathy: A case report". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1889-1892. https://doi.org/10.3892/etm.2016.3149