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Article

Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3

  • Authors:
    • Chaoyu Sun
    • Lei Tong
    • Wenran Zhao
    • Yan Wang
    • Yuan Meng
    • Lexun Lin
    • Bingchen Liu
    • Yujia Zhai
    • Zhaohua Zhong
    • Xueqi Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Cell Biology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
  • Pages: 2220-2226
    |
    Published online on: August 22, 2016
       https://doi.org/10.3892/etm.2016.3607
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Abstract

Coxsackievirus B3 (CVB3) is a common causative agent in the development of inflammatory cardiomyopathy. However, whether the expression of peripheral blood microRNAs (miRNAs) is altered in this process is unknown. The present study investigated changes to miRNA expression in the peripheral blood of CVB3‑infected mice. Utilizing miRNA microarray technology, differential miRNA expression was examined between normal and CVB3‑infected mice. The present results suggest that specific miRNAs were differentially expressed in the peripheral blood of mice infected with CVB3, varying with infection duration. Using miRNA microarray analysis, a total of 96 and 89 differentially expressed miRNAs were identified in the peripheral blood of mice infected with CVB3 for 3 and 6 days, respectively. Quantitative polymerase chain reaction was used to validate differentially expressed miRNAs, revealing a consistency of these results with the miRNA microarray analysis results. The biological functions of the differentially expressed miRNAs were then predicted by bioinformatics analysis. The potential biological roles of differentially expressed miRNAs included hypertrophic cardiomyopathy, dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. These results may provide important insights into the mechanisms responsible for the progression of CVB3 infection.
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Copy and paste a formatted citation
Spandidos Publications style
Sun C, Tong L, Zhao W, Wang Y, Meng Y, Lin L, Liu B, Zhai Y, Zhong Z, Li X, Li X, et al: Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3. Exp Ther Med 12: 2220-2226, 2016.
APA
Sun, C., Tong, L., Zhao, W., Wang, Y., Meng, Y., Lin, L. ... Li, X. (2016). Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3. Experimental and Therapeutic Medicine, 12, 2220-2226. https://doi.org/10.3892/etm.2016.3607
MLA
Sun, C., Tong, L., Zhao, W., Wang, Y., Meng, Y., Lin, L., Liu, B., Zhai, Y., Zhong, Z., Li, X."Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3". Experimental and Therapeutic Medicine 12.4 (2016): 2220-2226.
Chicago
Sun, C., Tong, L., Zhao, W., Wang, Y., Meng, Y., Lin, L., Liu, B., Zhai, Y., Zhong, Z., Li, X."Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2220-2226. https://doi.org/10.3892/etm.2016.3607
Copy and paste a formatted citation
x
Spandidos Publications style
Sun C, Tong L, Zhao W, Wang Y, Meng Y, Lin L, Liu B, Zhai Y, Zhong Z, Li X, Li X, et al: Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3. Exp Ther Med 12: 2220-2226, 2016.
APA
Sun, C., Tong, L., Zhao, W., Wang, Y., Meng, Y., Lin, L. ... Li, X. (2016). Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3. Experimental and Therapeutic Medicine, 12, 2220-2226. https://doi.org/10.3892/etm.2016.3607
MLA
Sun, C., Tong, L., Zhao, W., Wang, Y., Meng, Y., Lin, L., Liu, B., Zhai, Y., Zhong, Z., Li, X."Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3". Experimental and Therapeutic Medicine 12.4 (2016): 2220-2226.
Chicago
Sun, C., Tong, L., Zhao, W., Wang, Y., Meng, Y., Lin, L., Liu, B., Zhai, Y., Zhong, Z., Li, X."Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2220-2226. https://doi.org/10.3892/etm.2016.3607
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