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Article

FeNO for detecting lower airway involvement in patients with allergic rhinitis

  • Authors:
    • Zheng Zhu
    • Yanqing Xie
    • Weijie Guan
    • Yi Gao
    • Shu Xia
    • Nanshan Zhong
    • Jinping Zheng
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Respiratory Disease, China Clinical Research Center of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 2336-2340
    |
    Published online on: August 23, 2016
       https://doi.org/10.3892/etm.2016.3616
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Abstract

Allergic rhinitis (AR) is a risk factor for asthma development. The value of fractional exhaled nitric oxide (FeNO) in detecting lower airway involvement in the progress of AR‑asthma march has not been evaluated. The aim of the present study was to investigate the value of FeNO in assessing lower airway inflammation and predicting bronchial hyperresponsiveness (BHR) in AR with or without asthma. FeNO and eosinophil count in induced sputum, and a methacholine bronchial provocation test were performed in 93 subjects, including: 45 AR patients (AR group); 20 patients with AR and asthma (AR with asthma group); and 28 normal controls (control group). The AR group was divided into two sub‑groups: AR with asymptomatic BHR group and AR without BHR group. Correlation between FeNO and eosinophil count was assessed. Receiver operating characteristic (ROC) curve was applied to evaluate the predictive and diagnostic value of FeNO in detecting BHR. The values of FeNO in the AR and AR with asthma groups were higher [29.5 (22.0) ppb and 61.5 (33.0) ppb] compared with the normal control group (16.0 (10.0) ppb), where the values in brackets indicate the interquartile range of the values. The percentages of eosinophils in induced sputum were 2.43±3.56, 7.36±4.98 and 18.58±11.26% in the control, AR and AR with asthma groups, respectively. For the diagnosis of BHR, the area under the curve (AUC) was 0.910 (95%CI 0.836, 0.984), with the sensitivity and specificity 0.846 and 0.817 when the cut‑off value takes 31.5 ppb. For diagnosis of asthma, the AUC was 0.873 (95%CI 0.753, 0.992) with sensitivity 0.857 and specificity 0.847 when taking the cut‑off value to be 38.0 ppb. The value of FeNO was well correlated with eosinophil count in the sputum. The measurement of FeNO is an effective method in detecting lower airway involvement in AR developing to asthma.
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1 

Zhang Y and Zhang L: Prevalence of allergic rhinitis in China. Allergy Asthma Immunol Res. 6:105–113. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Grossman J: One airway, one disease. CHEST. 111:(2 Suppl). 11S–16S. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Lin J, Su N, Liu G, Yin K, Zhou X, Shen H, Chen P, Chen R, Liu C, Wu C, et al: The impact of concomitant allergic rhinitis on asthma control: A cross-sectional nationwide survey in China. J Asthma. 51:34–43. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Bonay M, Neukirch C, Grandsaigne M, Leçon-Malas V, Ravaud P, Dehoux M and Aubier M: Changes in airway inflammation following nasal allergic challenge in patients with seasonal rhinitis. Allergy. 61:111–118. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Linneberg A, Nielsen N Henrik, Frølund L, Madsen F, Dirksen A and Jørgensen T: Copenhagen Allergy Study: The link between allergic rhinitis and allergic asthma: A prospective population-based study. The copenhagen allergy study. Allergy. 57:1048–1052. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Brozek JL, Bousquet J, Baena-Cagnani CE, et al: Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 126:466–476. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Alvarez MJ, Olaguibel JM, Garcia BE, Tabar AI and Urbiola E: Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients. Allergy. 55:531–539. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Irvin CG: The nose: a window into the asthmatic lung? Clin Exp Allergy. 40:839–840. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Bhimrao SK, Wilson SJ and Howarth PH: Airway inflammation in atopic patients: a comparison of the upper and lower airways. Otolaryngol Head Neck Surg. 145:396–400. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Braunstahl GJ, Fokkens WJ, Overbeek SE, KleinJan A, Hoogsteden HC and Prins JB: Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways. Clin Exp Allergy. 33:579–587. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Smith AD, Cowan JO, Filsell S, McLachlan C, Monti-Sheehan G, Jackson P and Taylor DR: Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med. 169:473–478. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Wang DY, Goh DY, Ho AK, Chew FT, Yeoh KH and Lee BW: The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis. Allergy. 58:78–82. 2003. View Article : Google Scholar : PubMed/NCBI

13 

de Graaf-int Veld C, Garrelds IM, Koenders S and van Wijk R Gerth: Relationship between nasal hyperreactivity, mediators and eosinophils in patients with perennial allergic rhinitis and controls. Clin Exp Allergy. 26:903–908. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Global Strategy for Asthma Management and Prevention, . Global Initiative for Asthma (GINA). 2011, http://www.ginasthma.orgAccessed December 20, 2011.

15 

Luo W, Lai KF, Chen RC, Chen QL and Zhong NS: Establishment of reference values for cellularity in induced sputum of healthy adults in Guangzhou. Guo Ji Hu Xi Za Zhi She. 16:1213–1215. 2007.(In Chinese).

16 

American Thoracic Society; European Respiratory Society, . ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 171:912–930. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Jiang CY, Zheng JP, Guan WJ, Xie YQ, Gao Y, Liu QX, An JY, Yu XX and Liu WT: Reference ranges and predicted equations for fractional exhaled nitric oxide in adult hans. Zhong Guo Shi Yong Nei Ke Za Zhi. 8:608–613. 2012.(In Chinese).

18 

Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G and Wanger J: ATS/ERS Task Force: Standardization of spirometry. Eur Respir J. 26:319–338. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Zheng JP and Zhong NS: Normative values of pulmonary function testing in Chinese adults. Chin Med J (Engl). 115:50–54. 2002.PubMed/NCBI

20 

Schneider A, Schwarzbach J, Faderl B, Welker L, Karsch-Völk M and Jörres RA: FENO measurement and sputum analysis for diagnosing asthma in clinical practice. Respir Med. 107:209–216. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Marcucci F, Passalacqua G, Canonica GW, Frati F, Salvatori S, Dicara G, Petrini I, Bernini M, Novembre E, Bernardini R, et al: Lower airway inflammation before and after house dust mite nasal challenge: An age and allergen exposure-related phenomenon. Respir Med. 101:1600–1608. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Settipane RJ, Hagy GW and Settipane GA: Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Proc. 15:21–25. 1994. View Article : Google Scholar : PubMed/NCBI

23 

Stachler RJ: Comorbidities of asthma and the unified airway. Int Forum Allergy Rhinol. 5:S17–S22. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Moshe S, Slodownik D, Yagev Y, Segal N, Tavor M, Afek A and Zack O: Atopy as a risk factor for the development of asthma in young recruits. J Asthma. 52:453–457. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Z, Xie Y, Guan W, Gao Y, Xia S, Zhong N and Zheng J: FeNO for detecting lower airway involvement in patients with allergic rhinitis. Exp Ther Med 12: 2336-2340, 2016.
APA
Zhu, Z., Xie, Y., Guan, W., Gao, Y., Xia, S., Zhong, N., & Zheng, J. (2016). FeNO for detecting lower airway involvement in patients with allergic rhinitis. Experimental and Therapeutic Medicine, 12, 2336-2340. https://doi.org/10.3892/etm.2016.3616
MLA
Zhu, Z., Xie, Y., Guan, W., Gao, Y., Xia, S., Zhong, N., Zheng, J."FeNO for detecting lower airway involvement in patients with allergic rhinitis". Experimental and Therapeutic Medicine 12.4 (2016): 2336-2340.
Chicago
Zhu, Z., Xie, Y., Guan, W., Gao, Y., Xia, S., Zhong, N., Zheng, J."FeNO for detecting lower airway involvement in patients with allergic rhinitis". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2336-2340. https://doi.org/10.3892/etm.2016.3616
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Z, Xie Y, Guan W, Gao Y, Xia S, Zhong N and Zheng J: FeNO for detecting lower airway involvement in patients with allergic rhinitis. Exp Ther Med 12: 2336-2340, 2016.
APA
Zhu, Z., Xie, Y., Guan, W., Gao, Y., Xia, S., Zhong, N., & Zheng, J. (2016). FeNO for detecting lower airway involvement in patients with allergic rhinitis. Experimental and Therapeutic Medicine, 12, 2336-2340. https://doi.org/10.3892/etm.2016.3616
MLA
Zhu, Z., Xie, Y., Guan, W., Gao, Y., Xia, S., Zhong, N., Zheng, J."FeNO for detecting lower airway involvement in patients with allergic rhinitis". Experimental and Therapeutic Medicine 12.4 (2016): 2336-2340.
Chicago
Zhu, Z., Xie, Y., Guan, W., Gao, Y., Xia, S., Zhong, N., Zheng, J."FeNO for detecting lower airway involvement in patients with allergic rhinitis". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2336-2340. https://doi.org/10.3892/etm.2016.3616
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