Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2016 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 12 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

  • Authors:
    • Yan‑Mei Xu
    • Guo‑Hua Ding
    • Jie Huang
    • Yan Xiong
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 2741-2746
    |
    Published online on: September 6, 2016
       https://doi.org/10.3892/etm.2016.3674
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tanshinone IIA is a chemical compound extracted from the root of traditional Chinese herb Salvia miltiorrhiza Bunge. Tanshinone IIA has been suggested to possess anti‑inflammatory activity and antioxidizing capability. Recently, accumulating results have indicated the antitumor activity of tanshinone IIA; thus, it has attracted increasing attention. In addition, tanshinone IIA has been indicated to attenuate ischemia/reperfusion induced renal injury (I/RIRI); however, little is known regarding the underlying mechanisms involved in this process. In the present study an I/RIRI rat model was used to analyze the effects of tanshinone IIA on myeloperoxidase (MPO), TNF‑α and IL‑6 activities using ELISA kits. Furthermore, macrophage migration inhibitory factor (MIF), cleaved caspase‑3, B‑cell lymphoma 2 (Bcl‑2) and p38 mitogen‑activated protein kinase (MAPK) protein expression levels were evaluated using western blot analysis. The results indicated that tanshinone IIA protected renal function in I/RIRI rats. ELISA demonstrated that tanshinone IIA significantly reduced MIF, TNF‑α and IL‑6 activities in I/RIRI rats. Western blot analysis showed that tanshinone IIA significantly suppressed MIF, cleaved caspase‑3 and p38 MAPK protein expression levels in I/RIRI rats. The present results suggest that tanshinone IIA pretreatment attenuates I/RIRI via the downregulation of MPO expression, inflammation, MIF, cleaved caspase‑3 and p38 MAPK.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Hoff U, Lukitsch I, Chaykovska L, Ladwig M, Arnold C, Manthati VL, Fuller TF, Schneider W, Gollasch M, Muller DN, et al: Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. Kidney Int. 79:57–65. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zhang J, Yao Y, Xiao F, Lan X, Yu C, Zhang Y, Jiang C, Yang J, Pei G, Li Y, et al: Administration of dexamethasone protects mice against ischemia/reperfusion induced renal injury by suppressing PI3K/AKT signaling. Int J Clin Exp Pathol. 6:2366–2375. 2013.PubMed/NCBI

3 

Jo SK, Ko GJ, Boo CS, Cho WY and Kim HK: Heat preconditioning attenuates renal injury in ischemic ARF in rats: Role of heat-shock protein 70 on NF-kappaB-mediated inflammation and on tubular cell injury. J Am Soc Nephrol. 17:3082–3092. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Tan S, Wang G, Guo Y, Gui D and Wang N: Preventive effects of a natural anti-inflammatory agent, astragalosideIV, on ischemic acute kidney injury in rats. Evid Based Complement Alternat Med. 2013:2840252013. View Article : Google Scholar : PubMed/NCBI

5 

Wei Q, Xiao X, Fogle P and Dong Z: Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion. PLoS One. 9:e1066472014. View Article : Google Scholar : PubMed/NCBI

6 

Grossini E, Molinari C, Pollesello P, Bellomo G, Valente G, Mary D, Vacca G and Caimmi P: Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs. J Pharmacol Exp Ther. 342:376–388. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Qin Y, Alderliesten MC, Stokman G, Pennekamp P, Bonventre JV, de Heer E, Ichimura T, de Graauw M, Price LS and van de Water B: Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion. Am J Pathol. 179:2766–2778. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Collino M, Benetti E, Miglio G, Castiglia S, Rosa AC, Aragno M, Thiemermann C and Fantozzi R: Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats. Free Radic Biol Med. 50:345–353. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Di Paola R, Genovese T, Impellizzeri D, Ahmad A, Cuzzocrea S and Esposito E: The renal injury and inflammation caused by ischemia-reperfusion are reduced by genetic inhibition of TNF-αR1: A comparison with infliximab treatment. Eur J Pharmacol. 700:134–146. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Mizutani A, Okajima K, Uchiba M, Isobe H, Harada N, Mizutani S and Noguchi T: Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. Blood. 101:3029–3036. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Isaka Y, Suzuki C, Abe T, Okumi M, Ichimaru N, Imamura R, Kakuta Y, Matsui I, Takabatake Y, Rakugi H, et al: Bcl-2 protects tubular epithelial cells from ischemia/reperfusion injury by dual mechanisms. Transplant Proc. 41:52–54. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Y, Zhang B, Xu DQ, Li WP, Xu M, Li JH, Xie XY, Fan QX, Liu W, Mu DG, et al: Tanshinone IIA attenuates seawater aspiration-induced lung injury by inhibiting macrophage migration inhibitory factor. Biol Pharm Bull. 34:1052–1057. 2011. View Article : Google Scholar : PubMed/NCBI

13 

van Poppel PC, Breedveld P, Abbink EJ, Roelofs H, van Heerde W, Smits P, Lin W, Tan AH, Russel FG, Donders R, et al: Salvia miltiorrhiza root water-extract (Danshen) has no beneficial effect on cardiovascular risk factors. A randomized double-blind cross-over trial. PLoS One. 10:e01286952015.

14 

Chen Y, Wu X, Yu S, Fauzee NJ, Wu J, Li L, Zhao J and Zhao Y: Neuroprotective capabilities of tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats. Biol Pharm Bull. 35:164–170. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Wen PY, Li J, Lu BL, Liu J, Yang FZ, Zhou L, Luo H, Li WW and Zhou J: Tanshinone IIA increases levels of NeuN, protein disulfide isomerase, and Na+/K+-ATPase and decreases evidence of microglial activation after cerebral ischemic injury. Neuroreport. 27:435–444. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Hu H, Zhai C, Qian G, Gu A, Liu J, Ying F, Xu W, Jin D, Wang H, Hu H, et al: Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression and inflammatory reaction. Pharm Biol. 53:1752–1758. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhang L, Gan W and An G: Influence of tanshinone IIA on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury. Neural Regen Res. 7:2882–2888. 2012.PubMed/NCBI

18 

Wang S, Zang W, Yang Y, Zhang Q, Zhao M, Gao Z, Li G, Meng Q, Liu Q and Zheng X: Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: Correlation with scavenging free radical. Environ Toxicol Pharmacol. 36:403–410. 2013. View Article : Google Scholar : PubMed/NCBI

19 

El Morsy EM, Ahmed MA and Ahmed AA: Attenuation of renal ischemia/reperfusion injury by açaí extract preconditioning in a rat model. Life Sci. 123:35–42. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wang F, Yu G, Liu SY, Li JB, Wang JF, Bo LL, Qian LR, Sun XJ and Deng XM: Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats. J Surg Res. 167:e339–e344. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Qi YY, Xiao L, Zhang LD, Song SH, Mei Y, Chen T, Tang JM, Liu F, Ding GS, Shi YZ and Wang QX: Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion. Front Biosci (Elite Ed). 4:1303–1313. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Wang H, Xu L, Zhao J, Wang D, Guo R, Wang J, Gong W, Liu T, Zhang Y and Dong L: Regulatory mechanism of pyrrolidine dithiocarbamate is mediated by nuclear factor-κB and inhibits neutrophil accumulation in ARDS mice. Exp Ther Med. 8:614–622. 2014.PubMed/NCBI

23 

Kurcer Z, Oguz E, Ozbilge H, Baba F, Aksoy N, Celik H, Cakir H and Gezen MR: Melatonin protects from ischemia/reperfusion-induced renal injury in rats: This effect is not mediated by proinflammatory cytokines. J Pineal Res. 43:172–178. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Ragab D, Abdallah DM and El-Abhar HS: Cilostazol renoprotective effect: Modulation of PPAR-γ, NGAL, KIM-1 and IL-18 underlies its novel effect in a model of ischemia-reperfusion. PLoS One. 9:e953132014. View Article : Google Scholar : PubMed/NCBI

25 

Chen Y, Wu X, Yu S, Lin X, Wu J, Li L, Zhao J and Zhao Y: Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats. PLoS One. 7:e401652012. View Article : Google Scholar : PubMed/NCBI

26 

Yin X, Yin Y, Cao FL, Chen YF, Peng Y, Hou WG, Sun SK and Luo ZJ: Tanshinone IIA attenuates the inflammatory response and apoptosis after traumatic injury of the spinal cord in adult rats. PLoS One. 7:e383812012. View Article : Google Scholar : PubMed/NCBI

27 

Yang CC, Lin LC, Wu MS, Chien CT and Lai MK: Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling. Transplantation. 88:1251–1260. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Yan XG, Cheng BH, Wang X, Ding LC, Liu HQ, Chen J and Bai B: Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury. Neural Regen Res. 10:766–771. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, Goujon JM, Ogier-Denis E and Vandewalle A: Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury. Cell Death Differ. 17:1474–1485. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Zhao WY, Han S, Zhang L, Zhu YH, Wang LM and Zeng L: Mitochondria-targeted antioxidant peptide SS31 prevents hypoxia/reoxygenation-induced apoptosis by down-regulating p66Shc in renal tubular epithelial cells. Cell Physiol Biochem. 32:591–600. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zhang MQ, Zheng YL, Chen H, Tu JF, Shen Y, Guo JP, Yang XH, Yuan SR, Chen LZ, Chai JJ, et al: Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway. Acta Pharmacol Sin. 34:1386–1396. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Zhou L, Bondy SC, Jian L, Wen P, Yang F, Luo H, Li W and Zhou J: Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases−3 and −8. Neuroscience. 288:105–111. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Chien CT, Shyue SK and Lai MK: Bcl-xL augmentation potentially reduces ischemia/reperfusion induced proximal and distal tubular apoptosis and autophagy. Transplantation. 84:1183–1190. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Chien CT, Chang TC, Tsai CY, Shyue SK and Lai MK: Adenovirus-mediated bcl-2 gene transfer inhibits renal ischemia/reperfusion induced tubular oxidative stress and apoptosis. Am J Transplant. 5:1194–1203. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Zhou WJ, Gui QF, Wu Y and Yang YM: Tanshinone IIA protects against methylglyoxal-induced injury in human brain microvascular endothelial cells. Int J Clin Exp Med. 8:1985–1992. 2015.PubMed/NCBI

36 

Lempiäinen J, Finckenberg P, Mervaala EE, Storvik M, Kaivola J, Lindstedt K, Levijoki J and Mervaala EM: Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury. Pharmacol Res Perspect. 2:e000452014. View Article : Google Scholar : PubMed/NCBI

37 

Park KM, Kramers C, Vayssier-Taussat M, Chen A and Bonventre JV: Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation and inflammation by remote transient ureteral obstruction. J Biol Chem. 277:2040–2049. 2002. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu YM, Ding GH, Huang J and Xiong Y: Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury. Exp Ther Med 12: 2741-2746, 2016.
APA
Xu, Y., Ding, G., Huang, J., & Xiong, Y. (2016). Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury. Experimental and Therapeutic Medicine, 12, 2741-2746. https://doi.org/10.3892/etm.2016.3674
MLA
Xu, Y., Ding, G., Huang, J., Xiong, Y."Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury". Experimental and Therapeutic Medicine 12.4 (2016): 2741-2746.
Chicago
Xu, Y., Ding, G., Huang, J., Xiong, Y."Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2741-2746. https://doi.org/10.3892/etm.2016.3674
Copy and paste a formatted citation
x
Spandidos Publications style
Xu YM, Ding GH, Huang J and Xiong Y: Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury. Exp Ther Med 12: 2741-2746, 2016.
APA
Xu, Y., Ding, G., Huang, J., & Xiong, Y. (2016). Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury. Experimental and Therapeutic Medicine, 12, 2741-2746. https://doi.org/10.3892/etm.2016.3674
MLA
Xu, Y., Ding, G., Huang, J., Xiong, Y."Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury". Experimental and Therapeutic Medicine 12.4 (2016): 2741-2746.
Chicago
Xu, Y., Ding, G., Huang, J., Xiong, Y."Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2741-2746. https://doi.org/10.3892/etm.2016.3674
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team