Effect of general anesthesia on serum β-amyloid protein and regional cerebral oxygen saturation of elderly patients after subtotal gastrectomy

Yu,Peng; Wang,Hua; Mu,Lei; Ding,Xuemei; Ding,Wei

doi:10.3892/etm.2016.3814

Effect of general anesthesia on serum β-amyloid protein and regional cerebral oxygen saturation of elderly patients after subtotal gastrectomy

Authors:
- Peng Yu
- Hua Wang
- Lei Mu
- Xuemei Ding
- Wei Ding
View Affiliations

Affiliations: Department of Anesthesiology, Traditional Chinese Medical Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Otolaryngology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Neurology, Traditional Chinese Medical Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Surgery, Traditional Chinese Medical Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Neurosurgery, Traditional Chinese Medical Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China
Published online on: October 18, 2016 https://doi.org/10.3892/etm.2016.3814
Pages: 3561-3566
Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of the present study was to investigate the influence of general anesthesia on serum β-amyloid protein (Aβ) and regional cerebral oxygen saturation (rSO2) of elderly patients after subtotal gastrectomy. From June, 2014 to December, 2015, among 168 patients undergoing subtotal gastrectomy, the Mini-Mental State Examination and Montreal Cognitive Assessment was administered the day prior to surgery and the second and ninth days after the operation. In addition, we administered the tests to 168 healthy adult volunteers (healthy controls) who were treated in our hospital medical center in the same period. Near-infrared spectroscopy technology was used for continuous monitoring of the intraoperative rSO2, and the mean of intraoperative rSO2 was then calculated. Of the 168 patients, 28 developed postoperative cognitive dysfunction (POCD) and the remaining 140 patients were normal (control). The ELISA method was used to test the expression levels of serum Aβ in the three groups and statistical analyses were conducted. Serum Aβ level in the POCD group was significantly higher than that in the control and healthy control groups, and the difference was statistically significant (P<0.05). The rSO2 level in the patients with POCD was significantly lower than the control group (P<0.05). The correlation analysis with Aβ as an independent variable and other factors as dependent variables revealed that the serum Aβ level negatively correlated with rSO2 (r=-1.6749, P<0.05). The combined Aβ and rSO2 may be useful for the diagnosis and prevention of POCD after subtotal gastrectomy under general anesthesia.

View Figures

View References

1	Vatter H, Konczalla J and Seifert V: Endothelin related pathophysiology in cerebral vasospasm: what happens to the cerebral vessels? Acta Neurochir Suppl. 110:177–l80. 2011.PubMed/NCBI
2	Peng L, Xu L and Ouyang W: Role of peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): a meta-analysis. PLoS One. 8:e796242013. View Article : Google Scholar : PubMed/NCBI
3	Hu Y, Shi S, Liu X, Hu Z, Huang W, Wang D, Xu J, Cheng B, Fang X and Shu Q: Effects of heart bypass surgery on plasma Aβ40 and Aβ42 levels in infants and young children. Medicine (Baltimore). 95:e26842016. View Article : Google Scholar : PubMed/NCBI
4	Saito S and Ishii H: Early detection of iliac artery rupture by sudden steep reduction of regional saturation of oxygen at the ipsilateral foot during transcatheter aortic valve implantation - a case report. Masui. 65:184–188. 2016.(In Chinese). PubMed/NCBI
5	Venerito M, Vasapolli R and Malfertheiner P: Prevention, early diagnosis and therapy of gastric cancer. MMW Fortschr Med. 158:39–43. 2016.(In German). View Article : Google Scholar : PubMed/NCBI
6	Tuna AT, Akkoyun I, Darcin S and Palabiyik O: Effects of carbon dioxide insufflation on regional cerebral oxygenation during laparoscopic surgery in children: a prospective study. Rev Bras Anestesiol. 66:249–253. 2016.(In Portuguese). View Article : Google Scholar : PubMed/NCBI
7	Li XM, Li F, Liu ZK and Shao MT: Investigation of one-lung ventilation postoperative cognitive dysfunction and regional cerebral oxygen saturation relations. J Zhejiang Univ Sci B. 16:1042–1048. 2015. View Article : Google Scholar : PubMed/NCBI
8	Ong HL, Subramaniam M, Abdin E, Wang P, Vaingankar JA, Lee SP, Shafie S, Seow E and Chong SA: Performance of Mini-Mental State Examination (MMSE) in long-stay patients with schizophrenia or schizoaffective disorders in a psychiatric institute. Psychiatry Res. 241:256–262. 2016. View Article : Google Scholar : PubMed/NCBI
9	Marceau EM, Lunn J, Berry J, Kelly PJ and Solowij N: The Montreal Cognitive Assessment (MoCA) is sensitive to head injury and cognitive impairment in a residential alcohol and other drug therapeutic community. J Subst Abuse Treat. 66:30–36. 2016. View Article : Google Scholar : PubMed/NCBI
10	Nesaratnam A, Nesaratnam N and Agius M: Cognitive impairment following use of anaesthetic agents: a review of the literature, and implications for future practice. Psychiatr Danub. 26:(Suppl 1). 53–55. 2014.PubMed/NCBI
11	Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y and Xie Z: Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep. 4:37662014.PubMed/NCBI
12	Vlisides P and Xie Z: Neurotoxicity of general anesthetics: an update. Curr Pharm Des. 18:6232–6240. 2012. View Article : Google Scholar : PubMed/NCBI
13	Erdem AF, Kayabasoglu G, Tas Tuna A,, Palabiyik O, Tomak Y and Beyaz SG: Effect of controlled hypotension on regional cerebral oxygen saturation during rhinoplasty: a prospective study. J Clin Monit Comput. 30:655–660. 2016. View Article : Google Scholar : PubMed/NCBI
14	Ide K and Secher NH: Cerebral blood flow and metabolism during exercise. Prog Neurobiol. 61:397–414. 2000. View Article : Google Scholar : PubMed/NCBI
15	Picton P, Dering A, Alexander A, Neff M, Miller BS, Shanks A, Housey M and Mashour GA: Influence of ventilation strategies and anesthetic techniques on regional cerebral oximetry in the beach chair position: a prospective interventional study with a randomized comparison of two anesthetics. Anesthesiology. 123:765–774. 2015. View Article : Google Scholar : PubMed/NCBI
16	Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, et al: Dynamics of β-amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor. J Pharmacol Exp Ther. 312:635–643. 2005. View Article : Google Scholar : PubMed/NCBI
17	Hametner C, Stanarcevic P, Stampfl S, Rohde S, Veltkamp R and Bösel J: Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study. J Cereb Blood Flow Metab. 35:1722–1728. 2015. View Article : Google Scholar : PubMed/NCBI
18	Mousa WF, Mowafi HA, Al-Metwalli RR, Al-Ghamdi AA and Al-Gameel HZ: Preoperative mannitol infusion improves perioperative cerebral oxygen saturation and enhances postoperative recovery after laparoscopic cholecystectomy. Saudi Med J. 36:1199–1204. 2015. View Article : Google Scholar : PubMed/NCBI
19	Xie Z and Tanzi RE: Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol. 41:346–359. 2006. View Article : Google Scholar : PubMed/NCBI
20	Jo YY, Kim JY, Park CK, Chang YJ and Kwak HJ: The effect of ventilation strategy on arterial and cerebral oxygenation during laparoscopic bariatric surgery. Obes Surg. 26:339–344. 2016. View Article : Google Scholar : PubMed/NCBI
21	Ding L, Zhang H, Mi W, Sun L, Zhang X, Ma X and Li H: Effects of carbon dioxide pneumoperitoneum and steep Trendelenburg positioning on cerebral blood backflow during robotic radical prostatectomy. Nan Fang Yi Ke Da Xue Xue Bao. 35:712–715. 2015.(In Chinese). PubMed/NCBI
22	Lin R, Zhang F, Xue Q and Yu B: Accuracy of regional cerebral oxygen saturation in predicting postoperative cognitive dysfunction after total hip arthroplasty: regional cerebral oxygen saturation predicts POCD. J Arthroplasty. 28:494–497. 2013. View Article : Google Scholar : PubMed/NCBI