Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration

  • Authors:
    • Yi Dong
    • Guangming Wan
    • Panshi Yan
    • Yue Chen
    • Wenzhan Wang
    • Guanghua Peng
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3923-3926
    |
    Published online on: November 8, 2016
       https://doi.org/10.3892/etm.2016.3886
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

We analyzed the effects of anti-vascular endothelial growth factor (VEGF) drugs combined with photodynamic therapy (PDT) in the treatment of age-related macular degeneration (AMD). Ninety-six cases (192 eyes) of AMD were included in this study and randomly divided into the observation group and control group (n=48 cases per group). The control group was administered the treatment of Lucentis intravitreal injection alone and the observation group was administered Lucentis combined with PDT. The therapeutic effects were compared. The best corrected visual acuity of patients in the two groups increased gradually after treatment. Patients in the observation group had a significantly higher visual acuity when compared to the control group 1 and 6 months post-operation. The differences were statistically significant (P<0.05). The proportion of patients with vision improvement in the observation group was higher than that in the control group from 1 to 6 months; differences were statistically significant (P<0.05). Through detection by color Doppler ultrasound within 6 months after treatment, we observed that the peak systolic velocity and arterial end diastolic velocity of retrobulbar optic nerve bitemporal PCA of the observation group were higher than those of the control group. The values of arterial resistance index and pulsatility index of the observation group were lower than those of control group. The differences were statistically significant (P<0.05). Six months after treatment, the value of central foveal thickness of the observation group was lower than that of the control group, the value of mean sensitivity of visual field parameter 10˚ and 4˚ was higher in the observation group than in the control group, and the absolute value of mean defects in the observation group were lower than that of the control group. In summary, the differences were statistically significant (P<0.05). Anti-VEGF drugs combined with PDT can optimize the overall vision of patients with AMD, improve hemodynamic parameters and reduce visual field defects.
View Figures

Figure 1

View References

1 

Cho HJ, Kim KM, Kim HS, Lee DW, Kim CG and Kim JW: Response of pigment epithelial detachment to anti-vascular endothelial growth factor treatment in age-related macular degeneration. Am J Ophthalmol. 166:112–119. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ueda K, Zhao J, Kim HJ and Sparrow JR: Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration. Proc Natl Acad Sci USA. 113:6904–6909. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Novais EA, Badaró E, Hirai FE, Jorge FA, Leal P, Farah ME and Rodrigues EB: Daily optical coherence tomography examinations after first antivascular endothelial growth factor injections: an interventional case series. J Ophthalmol. 2016:69718312016. View Article : Google Scholar : PubMed/NCBI

4 

Heimes B, Gunnemann F, Ziegler M, Gutfleisch M, Spital G, Pauleikhoff D and Lommatzsch A: Compliance of age related macular degeneration patients undergoing anti-VEGF therapy: analysis and suggestions for improvement. Ophthalmologe. 6:Jun 6–2016.(In German) (Epub ahead of print).

5 

Senra H, Ali Z, Balaskas K and Aslam T: Psychological impact of anti-VEGF treatments for wet macular degeneration-a review. Graefes Arch Clin Exp Ophthalmol. 4:12–13. 2016.

6 

Arias L, Gómez-Ulla F and Ruiz-Moreno JM: Ranibizumab in monotherapy and combined with photodynamic therapy for retinal angiomatous proliferation. Clin Ophthalmol. 10:861–869. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Wu B, Li J, Lin H and Wu H: Different strategies for the treatment of age-related macular degeneration in China: an economic evaluation. J Ophthalmol. 2016:76898622016. View Article : Google Scholar : PubMed/NCBI

8 

Scherer KM, Bisby RH, Botchway SW and Parker AW: New approaches to photodynamic therapy from type I, II and III to type IV using one or more photons. Anticancer Agents Med Chem. 13:17–18. 2016.

9 

Catchpole T, Daniels T, Perkins J and Csaky KG: Method development to quantify Bv8 expression in circulating CD11b+ cells in patients with neovascular age-related macular degeneration (nvAMD) exhibiting anti-VEGF refractoriness. Exp Eye Res. 148:45–51. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Otsuji T, Sho K, Tsumura A, Koike N, Nishimura T and Takahashi K: Three-year results of a modified photodynamic therapy procedure (Ironing PDT) for age-related macular degeneration patients with large lesions. Clin Ophthalmol. 10:431–436. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Arnold JJ: Age-related macular degeneration: anti-vascular endothelial growth factor treatment. BMJ Clin Evid. 24:07012016.

12 

Uzun S and Pehlivan E: Comparison of intravitreal aflibercept and ranibizumab injections on subfoveal and peripapillary choroidal thickness in eyes with neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2:15–16. 2016.

13 

Teper SJ, Nowinska A, Pilat J and Wylegala E: Photodynamic therapy in VEGF inhibition non-responders-pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography. Photodiagn Photodyn Ther. 13:108–113. 2016. View Article : Google Scholar

14 

Lee JP, Park JS, Kwon OW, You YS and Kim SH: Management of acute submacular hemorrhage with intravitreal injection of tenecteplase, anti-vascular endothelial growth factor and gas. Korean J Ophthalmol. 30:192–197. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Newman DK: Photodynamic therapy: current role in the treatment of chorioretinal conditions. Eye (Lond). 30:202–210. 2016. View Article : Google Scholar : PubMed/NCBI

16 

MacDonald DA, Martin J, Muthusamy KK, Luo JK, Pyles E, Rafique A, Huang T, Potocky T, Liu Y, Cao J, et al: Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes. Angiogenesis. 19:389–406. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Colombeau L, Acherar S, Baros F, Arnoux P, Gazzali AM, Zaghdoudi K, Toussaint M, Vanderesse R and Frochot C: Inorganic nanoparticles for photodynamic therapy. Top Curr Chem. 370:113–134. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Shahin M, Gad MA and Hamza W: Impact of intravitreal triamcinolone acetonide versus intravitreal bevacizumab on retrobulbar hemodynamic in patients with diabetic macular edema. Cutan Ocul Toxicol. 33:49–53. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Toklu Y, Cakmak HB, Raza S, Anayol A, Asik E and Simşek S: Short-term effects of intravitreal bevacizumab [Avastin®] on retrobulbar hemodynamics in patients with neovascular age-related macular degeneration. Acta Ophthalmol. 89:e41–e45. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Mete A, Saygili O, Mete A, Bayram M and Bekir N: Effects of intravitreal bevacizumab (Avastin) therapy on retrobulbar blood flow parameters in patients with neovascular age-related macular degeneration. J Clin Ultrasound. 38:66–70. 2010.PubMed/NCBI

21 

Sakalar YB, Senturk S, Yildirim M, Keklikci U, Alakus MF and Unlu K: Evaluation of retrobulbar blood flow by color doppler ultrasonography after intravitreal ranibizumab injection in patients with neovascular age-related macular degeneration. J Clin Ultrasound. 41:32–37. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Koizumi H, Kano M, Yamamoto A, Saito M, Maruko I, Kawasaki R, Sekiryu T, Okada AA and Iida T: Short-term changes in choroidal thickness after aflibercept therapy for neovascular age-related macular degeneration. Am J Ophthalmol. 159:627–633. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Smith RT: New understanding of age-related macular degeneration through quantitative autofluorescence. JAMA Ophthalmol. 134:824–826. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Dong Y, Wan G, Yan P, Chen Y, Wang W and Peng G: Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration. Exp Ther Med 12: 3923-3926, 2016.
APA
Dong, Y., Wan, G., Yan, P., Chen, Y., Wang, W., & Peng, G. (2016). Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration. Experimental and Therapeutic Medicine, 12, 3923-3926. https://doi.org/10.3892/etm.2016.3886
MLA
Dong, Y., Wan, G., Yan, P., Chen, Y., Wang, W., Peng, G."Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration". Experimental and Therapeutic Medicine 12.6 (2016): 3923-3926.
Chicago
Dong, Y., Wan, G., Yan, P., Chen, Y., Wang, W., Peng, G."Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3923-3926. https://doi.org/10.3892/etm.2016.3886
Copy and paste a formatted citation
x
Spandidos Publications style
Dong Y, Wan G, Yan P, Chen Y, Wang W and Peng G: Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration. Exp Ther Med 12: 3923-3926, 2016.
APA
Dong, Y., Wan, G., Yan, P., Chen, Y., Wang, W., & Peng, G. (2016). Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration. Experimental and Therapeutic Medicine, 12, 3923-3926. https://doi.org/10.3892/etm.2016.3886
MLA
Dong, Y., Wan, G., Yan, P., Chen, Y., Wang, W., Peng, G."Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration". Experimental and Therapeutic Medicine 12.6 (2016): 3923-3926.
Chicago
Dong, Y., Wan, G., Yan, P., Chen, Y., Wang, W., Peng, G."Effect of anti-VEGF drugs combined with photodynamic therapy in the treatment of age-related macular degeneration". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3923-3926. https://doi.org/10.3892/etm.2016.3886
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team