Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction

  • Authors:
    • Xing‑Hua Wang
    • Guang‑Ping Li
    • Wan‑Song Yang
    • Zhan‑Quan Jiao
    • Hong‑Mei Liu
    • Yan‑Ping Ni
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Tianjin Key Laboratory of Ionic‑Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3927-3933
    |
    Published online on: November 8, 2016
       https://doi.org/10.3892/etm.2016.3888
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Guanmaitong (GMT) is a traditional Chinese herbal compound that has been used for the treatment of coronary heart disease (CHD) and other cardiovascular diseases. However, the efficacy of GMT in treating cardiovascular diseases remains unclear. The aim of the present study was to investigate the protective mechanisms and identify the targeted proteins and signaling networks associated with the physiological activity of GMT in a rat model of acute myocardial infarction (AMI). Sprague‑Dawley rats were randomly allocated into five groups: Control group (sham‑operated), the model group, and small, medium, and large dosage GMT groups. The rat model of AMI was established via ligation of the coronary artery. The results indicate that GMT was able to reduce myocardial infarction size and improve the activities of tumor necrosis factor‑α (TNF‑α), intercellular adhesion molecule 1 (ICAM‑1) and interleukin‑1. Furthermore, the reduced apoptotic index of the GMT‑treated cardiocytes (P<0.05 vs. model group) was in accordance with the downregulated expression of Bax and the upregulated expression of Bcl‑2. In conclusion, GMT may exert a protective potential against myocardial infarction injury by inhibiting apoptosis and inflammation of cardiomyocytes, and may offer a promising adjunct treatment for CHD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Pranavchand R and Reddy B: Current status of understanding of the genetic etiology of coronary heart disease. J Postgrad Med. 59:30–41. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Li C, Pei F, Zhu X, Duan DD and Zeng C: Circulating microRNAs as novel and sensitive biomarkers of acute myocardial infarction. Clin Biochem. 45:727–732. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Frangogiannis NG: The immune system and the remodeling infarcted heart: Cell biological insights and therapeutic opportunities. J Cardiovasc Pharmacol. 63:185–195. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Dauwe DF and Janssens SP: Stem cell therapy for the treatment of myocardial infarction. Curr Pharm Des. 17:3328–3340. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Liang X, Chen X, Liang Q, Zhang H, Hu P, Wang Y and Luo G: Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats. J Proteome Res. 10:790–799. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Wang Y, Qian P, Liu P, Wei L, Cao M, Zhou L, Zhou D and Lin ZX: Effects of Panax notoginseng flower extract on the TGF-β/Smad signal transduction pathway in heart remodeling of human chymase transgenic mice. Mol Med Rep. 5:1443–1448. 2012.PubMed/NCBI

7 

Chen KJ and Xu H: The integration of traditional Chinese medicine and Western medicine. European Review. 11:225–235. 2003.

8 

Zhu YP and Woerdenbag HJ: Traditional Chinese herbal medicine. Pharmacy World and Science. 17:103–112. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Pan SY, Chen SB, Dong HG, Yu ZL, Dong JC, Long ZX, Fong WF, Han YF and Ko KM: New perspectives on Chinese herbal medicine (Zhong-Yao) research and development. Evid Based Complement Alternat Med. 2011:4037092011. View Article : Google Scholar : PubMed/NCBI

10 

Ling S, Nheu L, Dai A, Guo Z and Komesaroff P: Effects of four medicinal herbs on human vascular endothelial cells in culture. Int J Cardiol. 128:350–358. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Hong CY, Lo YC, Tan FC, Wei YH and Chen CF: Astrafalus membranaceus and Polygonum multiflourm protect rat heart mitochondria against lipid peroxidation. Am J Chin Med. 22:63–70. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Zhang SH, Wang WQ and Wang JL: Protective effect of tetrahydroxystilbene glucoside on cardiotoxicity induced by doxorubicin in vitro and in vivo. Acta Pharmacol Sin. 30:1479–1487. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Zheng CS, Xu XJ, Ye HZ, Wu GW, Xu HF, Li XH, Huang SP and Liu XX: Computational pharmacological comparison of Salvia miltiorrhiza and Panax notoginseng used in the therapy of cardiovascular diseases. Exp Ther Med. 6:1163–1168. 2013.PubMed/NCBI

14 

Fong CC, Wei F, Chen Y, Yu WK, Koon CM, Leung PC, Fung KP, Lau CB and Yang M: Danshen-Gegen decoction exerts proliferative effect on rat cardiac myoblasts H9c2 via MAPK and insulin pathways. J Ethnopharmacol. 138:60–66. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wing-Shing Cheung D, Koon CM, Ng CF, Leung PC, Fung KP, Kar-Sing Poon S and Bik-San Lau C: The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula. J Ethnopharmacol. 143:859–866. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Wan LH, Chen J, Li L, Xiong WB and Zhou LM: Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats. Pharm Biol. 49:1204–1209. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Han SY, Li HX, Ma X, Zhang K, Ma ZZ, Jiang Y and Tu PF: Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats. Ethnopharmacol. 145:722–727. 2013. View Article : Google Scholar

18 

Maclean D, Fishbein MC, Braunwald E and Maroko PR: Long-term preservation of ischemic myocardium after experimentalcoronary artery occlusion. J Clin Invest. 61:541–551. 1978. View Article : Google Scholar : PubMed/NCBI

19 

Whelan RS, Kaplinskiy V and Kitsis RN: Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physio. 72:19–44. 2010. View Article : Google Scholar

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCt method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Favaloro B, Allocati N, Graziano V, Di Ilio C and De Laurenzi V: Role of apoptosis in disease. Aging (Albany NY). 4:330–349. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Lee SD, Chu CH, Huang EJ, Lu MC, Liu JY, Liu CJ, Hsu HH, Lin JA, Kuo WW and Huang CY: Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation. Am J Physiol Endocrinol Metab. 291:E306–E314. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Liou CM, Tsai SC, Kuo CH, Ting H and Lee SD: Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse. Int J Mol Sci. 15:5988–6001. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata SK and Sinha-Hikim AP: Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 16:563–573. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Gill C, Mestril R and Samali A: Losing heart: The role of apoptosis in heart disease-a novel therapeutic target? FASEB J. 16:135–146. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Bansal N, Marchion DC, Bicaku E, Xiong Y, Chen N, Stickles XB, Sawah EA, Wenham RM, Apte SM, Gonzalez-Bosquet J, et al: BCL2 antagonist of cell death kinases, phosphatases and ovarian cancer sensitivity to cisplatin. J Gynecol Oncol. 23:35–42. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Xu Z, Dong Y, Wu X, Zhang J, McAuliffe S, Pan C, Zhang Y, Ichinose F, Yue Y and Xie Z: The potential dual effects of anesthetic isoflurane on Aβ-induced apoptosis. Curr Alzheimer Res. 8:741–752. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Lin XM, Zhang ZY, Wang LF and Zhang L, Liu Y, Liu XL, Yang XC, Cui L and Zhang L: Attenuation of tumor necrosis factor-alpha elevation and improved heart function by postconditioning for 60 seconds in patients with acute myocardial infarction. Chin Med J (Engl). 123:1833–1839. 2010.PubMed/NCBI

29 

Tuttolomondo A, Di Raimondo D, Pecoraro R, Arnao V, Pinto A and Licata G: Inflammation in ischemic stroke subtypes. Curr Pharm Des. 18:4289–4310. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Chen M, Quintans J, Fuks Z, Thompson C, Kufe DW and Weichselbaum RR: Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor and ceramide. Cancer Res. 55:991–994. 1995.PubMed/NCBI

31 

Arnson Y: Circulating levels of adhesion molecules ICAM-1, VCAM-1, E-Selectin, VEGF and their associations with age and troponin in patients with acute coronary syndrome. J Am Coll Cardiol. 63:A1772014. View Article : Google Scholar

32 

Abbate A, Kontos MC, Grizzard JD, Biondi-Zoccai GG, Van Tassell BW, Robati R, Roach LM, Arena RA, Roberts CS, Varma A, et al: VCU-ART Investigators: Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction(Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). Am J Cardiol. 105:1371–1377. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Projahn D and Koenen RR: Platelets: key players in vascular inflammation. J Leukoc Biol. 92:1167–1175. 2012. View Article : Google Scholar : PubMed/NCBI

34 

van den Akker F, Deddens JC, Doevendans PA and Sluijter JP: Cardiac stem cell therapy to modulate inflammation upon myocardial infarction. Biochim Biophys Acta. 1830:2449–2458. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang XH, Li GP, Yang WS, Jiao ZQ, Liu HM and Ni YP: Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction. Exp Ther Med 12: 3927-3933, 2016.
APA
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., & Ni, Y. (2016). Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction. Experimental and Therapeutic Medicine, 12, 3927-3933. https://doi.org/10.3892/etm.2016.3888
MLA
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., Ni, Y."Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction". Experimental and Therapeutic Medicine 12.6 (2016): 3927-3933.
Chicago
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., Ni, Y."Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3927-3933. https://doi.org/10.3892/etm.2016.3888
Copy and paste a formatted citation
x
Spandidos Publications style
Wang XH, Li GP, Yang WS, Jiao ZQ, Liu HM and Ni YP: Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction. Exp Ther Med 12: 3927-3933, 2016.
APA
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., & Ni, Y. (2016). Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction. Experimental and Therapeutic Medicine, 12, 3927-3933. https://doi.org/10.3892/etm.2016.3888
MLA
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., Ni, Y."Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction". Experimental and Therapeutic Medicine 12.6 (2016): 3927-3933.
Chicago
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., Ni, Y."Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3927-3933. https://doi.org/10.3892/etm.2016.3888
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team