Open Access

Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction

  • Authors:
    • Xing‑Hua Wang
    • Guang‑Ping Li
    • Wan‑Song Yang
    • Zhan‑Quan Jiao
    • Hong‑Mei Liu
    • Yan‑Ping Ni
  • View Affiliations

  • Published online on: November 8, 2016     https://doi.org/10.3892/etm.2016.3888
  • Pages: 3927-3933
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Guanmaitong (GMT) is a traditional Chinese herbal compound that has been used for the treatment of coronary heart disease (CHD) and other cardiovascular diseases. However, the efficacy of GMT in treating cardiovascular diseases remains unclear. The aim of the present study was to investigate the protective mechanisms and identify the targeted proteins and signaling networks associated with the physiological activity of GMT in a rat model of acute myocardial infarction (AMI). Sprague‑Dawley rats were randomly allocated into five groups: Control group (sham‑operated), the model group, and small, medium, and large dosage GMT groups. The rat model of AMI was established via ligation of the coronary artery. The results indicate that GMT was able to reduce myocardial infarction size and improve the activities of tumor necrosis factor‑α (TNF‑α), intercellular adhesion molecule 1 (ICAM‑1) and interleukin‑1. Furthermore, the reduced apoptotic index of the GMT‑treated cardiocytes (P<0.05 vs. model group) was in accordance with the downregulated expression of Bax and the upregulated expression of Bcl‑2. In conclusion, GMT may exert a protective potential against myocardial infarction injury by inhibiting apoptosis and inflammation of cardiomyocytes, and may offer a promising adjunct treatment for CHD.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang XH, Li GP, Yang WS, Jiao ZQ, Liu HM and Ni YP: Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction. Exp Ther Med 12: 3927-3933, 2016
APA
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., & Ni, Y. (2016). Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction. Experimental and Therapeutic Medicine, 12, 3927-3933. https://doi.org/10.3892/etm.2016.3888
MLA
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., Ni, Y."Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction". Experimental and Therapeutic Medicine 12.6 (2016): 3927-3933.
Chicago
Wang, X., Li, G., Yang, W., Jiao, Z., Liu, H., Ni, Y."Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction". Experimental and Therapeutic Medicine 12, no. 6 (2016): 3927-3933. https://doi.org/10.3892/etm.2016.3888