Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2016 Volume 12 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation

  • Authors:
    • Liangchang Li
    • Hongmei Piao
    • Mingyu Zheng
    • Zhewu Jin
    • Liguang Zhao
    • Guanghai Yan
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Histology and Embryology, Yanbian University Medical College, Yanji, Jilin 133002, P.R. China, Department of Respiratory Medicine, Yanbian University, Yanji, Jilin 133000, P.R. China, Department of Respiratory Medicine, College of Pharmacy, Yanbian University, Yanji, Jilin 133002, P.R. China
  • Pages: 4175-4181
    |
    Published online on: November 15, 2016
       https://doi.org/10.3892/etm.2016.3903
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study is to determine the role of sesamin, the most abundant lignan in sesame seed oil, on the regulation of allergic airway inflammation in a murine asthma model. A BALB/c mouse model with allergic asthma was used to evaluate the effects of sesamin on nuclear factor‑kappa B (NF‑κB) activation. An enzyme‑linked immunosorbent assay was used to determine protein expression in bronchoalveolar lavage (BAL) fluids. Hematoxylin and eosin staining was performed to examine histological changes. Moreover, western blot analysis was used to detect the expression of proteins in tissues. Prior to administering sesamin, the mice developed the following pathophysiological features of asthma: An increase in the number of inflammatory cells, increased levels of interleukin (IL)‑4, IL‑5 and IL‑13, decreased levels of interferon‑γ in BAL fluids and lung tissues, increased immunoglobulin E (IgE) levels in the serum and an increased activation of NF‑κB in lung tissues. Following treatment with sesamin, the mice had evidently reduced peribronchiolar inflammation and airway inflammatory cell recruitment, inhibited production of several cytokines in BAL fluids and lung tissues, and decreased IgE levels. Following inhalation of ovalbumin, the administration of sesamin also inhibited the activation of NF‑κB. In addition, sesamin administration reduced the phosphorylation of p38 mitogen‑activated protein kinases (MAPKs). The present study demonstrates that sesamin decreases the activation of NF‑κB in order to attenuate allergic airway inflammation in a murine model of asthma, possibly via the regulation of phosphorylation of p38 MAPK. These observations provide an important molecular mechanism for the potential use of sesamin in preventing and/or treating asthma, as well as other airway inflammatory disorders.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Pascual RM and Peters SP: Airway remodeling contributes to the progressive loss of lung function in asthma: an overview. J Allergy Clin Immunol. 116:477–486. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Kay AB: Asthma and inflammation. J Allergy Clin Immunol. 87:893–910. 1991. View Article : Google Scholar : PubMed/NCBI

3 

Janssen EM, van Oosterhout AJ, van Rensen AJ, van Eden W, Nijkamp FP and Wauben MH: Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: Amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide. J Immunol. 164:580–588. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Mazzarella G, Bianco A, Catena E, De Palma R and Abbate GF: Th1/Th2 lymphocyte polarization in asthma. Allergy. 55:(Suppl 61). S6–S9. 2000. View Article : Google Scholar

5 

Primhak RA and Powell CV: AHR in asthma. Thorax. 57:186author reply 186. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR and Kay AB: Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med. 326:298–304. 1992. View Article : Google Scholar : PubMed/NCBI

7 

Tournoy KG, Kips JC and Pauwels RA: Is Th1 the solution for Th2 in asthma? Clin Exp Allergy. 32:17–29. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Kidd P: Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease. Altern Med Rev. 8:223–246. 2003.PubMed/NCBI

9 

Umetsu DT, McIntire JJ, Akbari O, Macaubas C and DeKruyff RH: Asthma: An epidemic of dysregulated immunity. Nat Immunol. 3:715–720. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Bao Z, Guan S, Cheng C, Wu S, Wong SH, Kemeny DM, Leung BP and Wong WS: A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway. Am J Respir Crit Care Med. 179:657–665. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Janssen-Heininger YM, Poynter ME, Aesif SW, Pantano C, Ather JL, Reynaert NL, Ckless K, Anathy V, van der Velden J, Irvin CG and van der Vliet A: Nuclear factor kappaB, airway epithelium and asthma: Avenues for redox control. Proc Am Thorac Soc. 6:249–255. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Tully JE, Hoffman SM, Lahue KG, Nolin JD, Anathy V, Lundblad LK, Daphtary N, Aliyeva M, Black KE, Dixon AE, et al: Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling. J Immunol. 191:5811–5821. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Ichikawa T, Sugiura H, Koarai A, Kikuchi T, Hiramatsu M, Kawabata H, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, et al: 25-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway. Exp Cell Res. 319:1176–1186. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Schieven GL: The biology of p38 kinase: A central role in inflammation. Curr Top Med Chem. 5:921–928. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Fu J, Meng X, He J and Gu J: Inhibition of inflammation by a p38 MAP kinase targeted cell permeable peptide. Med Chem. 4:597–604. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW and Natarajan V: Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. Biochem J. 393:657–668. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Saccani S, Pantano S and Natoli G: p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol. 3:69–75. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Woo CH, Lim JH and Kim JH: Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. J Immunol. 173:6973–6980. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Nasirullah and Latha RB: Storage stability of sunflower oil with added natural antioxidant concentrate from sesame seed oil. J Oleo Sci. 58:453–459. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Yokota T, Matsuzaki Y, Koyama M, Hitomi T, Kawanaka M, Enoki-Konishi M, Okuyama Y, Takayasu J, Nishino H, Nishikawa A, Osawa T and Sakai T: Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells. Cancer Sci. 98:1447–1453. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Utsunomiya T, Shimada M, Rikimaru T, Hasegawa H, Yamashita Y, Hamatsu T, Yamasaki M, Kaku S, Yamada K and Sugimachi K: Antioxidant and anti-inflammatory effects of a diet supplemented with sesamin on hepatic ischemia-reperfusion injury in rats. Hepatogastroenterology. 50:1609–1613. 2003.PubMed/NCBI

22 

Chavali SR, Zhong WW and Forse RA: Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: Effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. Prostaglandins Leukot Essent Fatty Acids. 58:185–191. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Iversen L, Fogh K and Kragballe K: Effect of dihomogammalinolenic acid and its 15-lipoxygenase metabolite on eicosanoid metabolism by human mononuclear leukocytes in vitro: Selective inhibition of the 5-lipoxygenase pathway. Arch Dermatol Res. 284:222–226. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Jeng KC, Hou RC, Wang JC and Ping LI: Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB. Immunol Lett. 97:101–106. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Phitak T, Pothacharoen P, Settakorn J, Poompimol W, Caterson B and Kongtawelert P: Chondroprotective and anti-inflammatory effects of sesamin. Phytochemistry. 80:77–88. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Bousquet J, Jeffery PK, Busse WW, Johnson M and Vignola AM: Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med. 161:1720–1745. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Wegmann M: Th2 cells as targets for therapeutic intervention in allergic bronchial asthma. Expert Rev Mol Diagn. 9:85–100. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Holt PG and Sly PD: Th2 cytokines in the asthma late-phase response. Lancet. 370:1396–1398. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Siebenlist U, Franzoso G and Brown K: Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 10:405–455. 1994. View Article : Google Scholar : PubMed/NCBI

30 

Baeuerle PA and Baltimore D: NF-kappa B: Ten years after. Cell. 87:13–20. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Baldwin AS Jr: The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu Rev Immunol. 14:649–683. 1996. View Article : Google Scholar : PubMed/NCBI

32 

Barnes PJ: Nuclear factor-kappa B. Int J Biochem Cell Biol. 29:867–870. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Ray A, Siegel MD, Prefontaine KE and Ray P: Anti-inflammation: Direct physical association and functional antagonism between transcription factor NF-KB and the glucocorticoid receptor. Chest. 107:(Suppl 3). S1391995. View Article : Google Scholar

34 

Imanifooladi AA, Yazdani S and Nourani MR: The role of nuclear factor-kappaB in inflammatory lung disease. Inflamm Allergy Drug Targets. 9:197–205. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Schaeffer HJ and Weber MJ: Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol. 19:2435–2444. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Davis RJ: Signal transduction by the JNK group of MAP kinases. Cell. 103:239–252. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Han J and Ulevitch RJ: Emerging targets for anti-inflammatory therapy. Nat Cell Biol. 1:E39–E40. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Kumar A, Lnu S, Malya R, Barron D, Moore J, Corry DB and Boriek AM: Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: Implications in asthma. FASEB J. 17:1800–1811. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha YH, Park JW, Joetham A, Poch K, Dakhama A, Dinarello CA and Gelfand EW: Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. Am J Respir Cell Mol Biol. 30:837–843. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Underwood DC, Osborn RR, Kotzer CJ, Adams JL, Lee JC, Webb EF, Carpenter DC, Bochnowicz S, Thomas HC, Hay DW and Griswold DE: SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. J Pharmacol Exp The. 293:281–288. 2000.

41 

Duan W, Chan JH, McKay K, Crosby JR, Choo HH, Leung BP, Karras JG and Wong WS: Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice. Am J Respir Crit Care Med. 171:571–578. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li L, Piao H, Zheng M, Jin Z, Zhao L and Yan G: Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation. Exp Ther Med 12: 4175-4181, 2016.
APA
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., & Yan, G. (2016). Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation. Experimental and Therapeutic Medicine, 12, 4175-4181. https://doi.org/10.3892/etm.2016.3903
MLA
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., Yan, G."Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation". Experimental and Therapeutic Medicine 12.6 (2016): 4175-4181.
Chicago
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., Yan, G."Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4175-4181. https://doi.org/10.3892/etm.2016.3903
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Piao H, Zheng M, Jin Z, Zhao L and Yan G: Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation. Exp Ther Med 12: 4175-4181, 2016.
APA
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., & Yan, G. (2016). Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation. Experimental and Therapeutic Medicine, 12, 4175-4181. https://doi.org/10.3892/etm.2016.3903
MLA
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., Yan, G."Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation". Experimental and Therapeutic Medicine 12.6 (2016): 4175-4181.
Chicago
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., Yan, G."Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor‑kappa B activation". Experimental and Therapeutic Medicine 12, no. 6 (2016): 4175-4181. https://doi.org/10.3892/etm.2016.3903
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team