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Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients

  • Authors:
    • Ming‑Yu Wang
    • Xian‑Bin Wang
    • Xue‑Hui Sun
    • Feng‑Li Liu
    • Sheng‑Chuan Huang
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology and Immunology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Rheumatology and Radiology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Rheumatology and Ultrasonography, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 905-908
    |
    Published online on: January 17, 2017
       https://doi.org/10.3892/etm.2017.4056
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Abstract

We studied the diagnostic value of high‑frequency color Doppler ultrasonography (HCDU) examination in combination with anti-cyclic citrullinated peptide (anti‑CCP) antibody testing in rheumatoid arthritis (RA) patients with finger joint damage. From January 2015 to December 2015, 80 patients diagnosed with RA with finger joints damage were enrolled in this study. Patients were examined with HCDU. Serum anti‑CCP antibody level was tested using ELISA, and results were compared with the healthy control group. Results obtained by ELISA demonstrated that the positive rate of anti‑CCP antibodies was 73.8% in the study group, and 10% in the control group. The negative rate was 26.2% in the study group, and 90% in the control group. HCDU examination suggested that the predominantly affected joint by bone erosion of RA with finger joint damage was MCP3 (16.7%), followed by PIP3 (14.1%), MCP2 (13.5%) and PIP2 (12.8%). The slightest affected joint was thumb metacarpophalangeal joint, followed by thumb, little finger metacarpophalangeal joint and proximal interphalangeal joint. The sensitivity of diagnosis of RA with finger joints damage with both HCDU and CCP antibody examination showed a significantly lower level compared with examination with each one of the methods alone, while specificity showed a significantly higher level. Thus, a combination of HCDU examination and anti‑CCP antibody testing can be considered useful to improve the early diagnostic rate of RA. HCDU examination is a sensitive, secure, atraumatic and easily‑operated diagnostic method for early RA patients with finger joint damage. When combined with anti‑CCP antibody testing, it will provide a better chance for RA patients, and give them hope for a better treatment and improved prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang MY, Wang XB, Sun XH, Liu FL and Huang SC: Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients. Exp Ther Med 13: 905-908, 2017.
APA
Wang, M., Wang, X., Sun, X., Liu, F., & Huang, S. (2017). Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients. Experimental and Therapeutic Medicine, 13, 905-908. https://doi.org/10.3892/etm.2017.4056
MLA
Wang, M., Wang, X., Sun, X., Liu, F., Huang, S."Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients". Experimental and Therapeutic Medicine 13.3 (2017): 905-908.
Chicago
Wang, M., Wang, X., Sun, X., Liu, F., Huang, S."Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients". Experimental and Therapeutic Medicine 13, no. 3 (2017): 905-908. https://doi.org/10.3892/etm.2017.4056
Copy and paste a formatted citation
x
Spandidos Publications style
Wang MY, Wang XB, Sun XH, Liu FL and Huang SC: Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients. Exp Ther Med 13: 905-908, 2017.
APA
Wang, M., Wang, X., Sun, X., Liu, F., & Huang, S. (2017). Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients. Experimental and Therapeutic Medicine, 13, 905-908. https://doi.org/10.3892/etm.2017.4056
MLA
Wang, M., Wang, X., Sun, X., Liu, F., Huang, S."Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients". Experimental and Therapeutic Medicine 13.3 (2017): 905-908.
Chicago
Wang, M., Wang, X., Sun, X., Liu, F., Huang, S."Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients". Experimental and Therapeutic Medicine 13, no. 3 (2017): 905-908. https://doi.org/10.3892/etm.2017.4056
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