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MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1

  • Authors:
    • Zhibo Chen
    • Mian Wang
    • Qiong He
    • Zilun Li
    • Yang Zhao
    • Wenjian Wang
    • Jieyi Ma
    • Yongxin Li
    • Guangqi Chang
  • View Affiliations / Copyright

    Affiliations: Division of Vascular Surgery, Guangdong Engineering Laboratory for Diagnosis and Treatment of Vascular Disease, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Division of Pathology, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Laboratory of General Surgery, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Vascular Surgery, The First Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1702-1710
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    Published online on: March 2, 2017
       https://doi.org/10.3892/etm.2017.4171
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Abstract

Oxidized low-density lipoprotein (ox-LDL) is a major and critical mediator of atherosclerosis, and the underlying mechanism is thought to involve the ox‑LDL‑induced dysfunction of endothelial cells (ECs). MicroRNAs (miRNAs), which are a group of small non‑coding RNA molecules that post‑transcriptionally regulate the expression of target genes, have been associated with diverse cellular functions and the pathogenesis of various diseases, including atherosclerosis. miRNA-98 (miR‑98) has been demonstrated to be involved in the regulation of cellular apoptosis; however, the role of miR-98 in ox-LDL-induced dysfunction of ECs and atherosclerosis has yet to be elucidated. Therefore, the present study aimed to investigate the role of miR‑98 in ox‑LDL‑induced dysfunction of ECs and the underlying mechanism. It was demonstrated that miR‑98 expression was markedly downregulated in ox‑LDL‑treated human umbilical vein ECs (HUVECs) and that miR-98 promoted the proliferation and alleviated apoptosis of HUVECs exposed to ox‑LDL. In addition, the results demonstrated that lectin‑like oxidized low‑density lipoprotein receptor 1 (LOX‑1) was a direct target of miR‑98 in HUVECs, as indicated by a luciferase assay. The results of the present study suggested that miR‑98 may inhibit the uptake of toxic ox‑LDL, maintain HUVEC proliferation and protect HUVECs against apoptosis via the suppression of LOX-1.
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1 

Santoro MM, Samuel T, Mitchell T, Reed JC and Stainier DY: Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet. 39:1397–1402. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Mano T, Masuyama T, Yamamoto K, Naito J, Kondo H, Nagano R, Tanouchi J, Hori M, Inoue M and Kamada T: Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound. Am Heart J. 131:231–238. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Pober JS, Min W and Bradley JR: Mechanisms of endothelial dysfunction, injury and death. Annu Rev Pathol. 4:71–95. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Triggle CR, Samuel SM, Ravishankar S, Marei I, Arunachalam G and Ding H: The endothelium: Influencing vascular smooth muscle in many ways. Can J Physiol Pharmacol. 90:713–738. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Otsuka F, Finn AV, Yazdani SK, Nakano M, Kolodgie FD and Virmani R: The importance of the endothelium in atherothrombosis and coronary stenting. Nat Rev Cardiol. 9:439–453. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sun C, Wu MH, Lee ES and Yuan SY: A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity. Arterioscler Thromb Vasc Biol. 32:2444–2451. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens R, Heyll K, Chun J, Saulnier-Blache JS, et al: Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab. 13:592–600. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, et al: Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation. 118:75–83. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Galle J, Hansen-Hagge T, Wanner C and Seibold S: Impact of oxidized low density lipoprotein on vascular cells. Atherosclerosis. 185:219–226. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H, Dean DB and Zhang C: MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ Res. 100:1579–1588. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Shan Z, Yao C, Li ZL, Teng Y, Li W, Wang JS, Ye CS, Chang GQ, Huang XL, Li XX, et al: Differentially expressed microRNAs at different stages of atherosclerosis in ApoE-deficient mice. Chin Med J (Engl). 126:515–520. 2013.PubMed/NCBI

13 

Wang M, Li W, Chang GQ, Ye CS, Ou JS, Li XX, Liu Y, Cheang TY, Huang XL and Wang SM: MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler Thromb Vasc Biol. 31:2044–2053. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Ouyang M, Shan Z, Ma J, Li J, Yao C, Zhu Z, Zhang L, Chen L, Chang G, et al: Involvement of microRNA-133a in the development of arteriosclerosis obliterans of the lower extremities via RhoA targeting. J Atheroscler Thromb. 22:424–432. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wang Y and Lee CG: MicroRNA and cancer-focus on apoptosis. J Cell Mol Med. 13:12–23. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Zhou DH, Wang X and Feng Q: EGCG enhances the efficacy of cisplatin by downregulating hsa-miR-98-5p in NSCLC A549 cells. Nutr Cancer. 66:636–644. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Xu S, Ogura S, Chen J, Little PJ, Moss J and Liu P: LOX-1 in atherosclerosis: Biological functions and pharmacological modifiers. Cell Mol Life Sci. 70:2859–2872. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Sawamura T, Wakabayashi I and Okamura T: LOX-1 in atherosclerotic disease. Clin Chim Acta. 440:157–163. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Mehta JL, Chen J, Hermonat PL, Romeo F and Novelli G: Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): A critical player in the development of atherosclerosis and related disorders. Cardiovasc Res. 69:36–45. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Li H, Li XX, Ma Q and Cui J: The variability of oxLDL-induced cytotoxicity on different types of cell lines. Cell Biochem Biophys. 67:635–644. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Gimbrone MA Jr, Topper JN, Nagel T, Anderson KR and Garcia-Cardeña G: Endothelial dysfunction, hemodynamic forces and atherogenesis. Ann N Y Acad Sci. 902:230–239. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Grover-Páez F and Zavalza-Gómez AB: Endothelial dysfunction and cardiovascular risk factors. Diabetes Res Clin Pract. 84:1–10. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Chen CH, Jiang W, Via DP, Luo S, Li TR, Lee YT and Henry PD: Oxidized low-density lipoproteins inhibit endothelial cell proliferation by suppressing basic fibroblast growth factor expression. Circulation. 101:171–177. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Yin G, Yang X, Li B, Yang M and Ren M: Connexin43 siRNA promotes HUVEC proliferation and inhibits apoptosis induced by ox-LDL: An involvement of ERK signaling pathway. Mol Cell Biochem. 394:101–107. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Dong Q, Xiang R, Zhang DY and Qin S: Ox-LDL increases OX40L in endothelial cells through a LOX-1-dependent mechanism. Braz J Med Biol Res. 46:765–770. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, et al: MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 20:368–376. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Pirillo A and Catapano AL: Soluble lectin-like oxidized low density lipoprotein receptor-1 as a biochemical marker for atherosclerosis-related diseases. Dis Markers. 35:413–418. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Shaw DJ, Seese R, Ponnambalam S and Ajjan R: The role of lectin-like oxidised low-density lipoprotein receptor-1 in vascular pathology. Diab Vasc Dis Res. 11:410–418. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T and Masaki T: An endothelial receptor for oxidized low-density lipoprotein. Nature. 386:73–77. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Akhmedov A, Rozenberg I, Paneni F, Camici GG, Shi Y, Doerries C, Sledzinska A, Mocharla P, Breitenstein A, Lohmann C, et al: Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo. Eur Heart J. 35:2839–2848. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Mehta JL and Li DY: Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells. Biochem Biophys Res Commun. 248:511–514. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Hermonat PL, Zhu H, Cao M and Mehta JL: LOX-1 transcription. Cardiovasc Drugs Ther. 25:393–400. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Lu J, Yang JH, Burns AR, Chen HH, Tang D, Walterscheid JP, Suzuki S, Yang CY, Sawamura T and Chen CH: Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. Circ Res. 104:619–627. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Mollace V, Gliozzi M, Musolino V, Carresi C, Muscoli S, Mollace R, Tavernese A, Gratteri S, Palma E, Morabito C, et al: Oxidized LDL attenuates protective autophagy and induces apoptotic cell death of endothelial cells: Role of oxidative stress and LOX-1 receptor expression. Int J Cardiol. 184:152–158. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Imanishi T, Hano T, Sawamura T, Takarada S and Nishio I: Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells. Circ J. 66:1060–1064. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Chen J, Mehta JL, Haider N, Zhang X, Narula J and Li D: Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells. Circ Res. 94:370–376. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Hong D, Bai YP, Gao HC, Wang X, Li LF, Zhang GG and Hu CP: Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway. Atherosclerosis. 235:310–317. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Sugawara T, Fujimura M, Noshita N, Kim GW, Saito A, Hayashi T, Narasimhan P, Maier CM and Chan PH: Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx. 1:17–25. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Han Z, Hendrickson EA, Bremner TA and Wyche JH: A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. J Biol Chem. 272:13–432, 13,436. 1997. View Article : Google Scholar : PubMed/NCBI

41 

Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 275:1132–1136. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Xiang H, Hochman DW, Saya H, Fujiwara T, Schwartzkroin PA and Morrison RS: Evidence for p53-mediated modulation of neuronal viability. J Neurosci. 16:6753–6765. 1996.PubMed/NCBI

43 

Kataoka H, Kume N, Miyamoto S, Minami M, Morimoto M, Hayashida K, Hashimoto N and Kita T: Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 21:955–960. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Li DY, Chen HJ and Mehta JL: Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation. Cardiovasc Res. 52:130–135. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Z, Wang M, He Q, Li Z, Zhao Y, Wang W, Ma J, Li Y and Chang G: MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1. Exp Ther Med 13: 1702-1710, 2017.
APA
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W. ... Chang, G. (2017). MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1. Experimental and Therapeutic Medicine, 13, 1702-1710. https://doi.org/10.3892/etm.2017.4171
MLA
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W., Ma, J., Li, Y., Chang, G."MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1". Experimental and Therapeutic Medicine 13.5 (2017): 1702-1710.
Chicago
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W., Ma, J., Li, Y., Chang, G."MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1702-1710. https://doi.org/10.3892/etm.2017.4171
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z, Wang M, He Q, Li Z, Zhao Y, Wang W, Ma J, Li Y and Chang G: MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1. Exp Ther Med 13: 1702-1710, 2017.
APA
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W. ... Chang, G. (2017). MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1. Experimental and Therapeutic Medicine, 13, 1702-1710. https://doi.org/10.3892/etm.2017.4171
MLA
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W., Ma, J., Li, Y., Chang, G."MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1". Experimental and Therapeutic Medicine 13.5 (2017): 1702-1710.
Chicago
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W., Ma, J., Li, Y., Chang, G."MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1702-1710. https://doi.org/10.3892/etm.2017.4171
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