Open Access

MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1

  • Authors:
    • Zhibo Chen
    • Mian Wang
    • Qiong He
    • Zilun Li
    • Yang Zhao
    • Wenjian Wang
    • Jieyi Ma
    • Yongxin Li
    • Guangqi Chang
  • View Affiliations

  • Published online on: March 2, 2017     https://doi.org/10.3892/etm.2017.4171
  • Pages: 1702-1710
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxidized low-density lipoprotein (ox-LDL) is a major and critical mediator of atherosclerosis, and the underlying mechanism is thought to involve the ox‑LDL‑induced dysfunction of endothelial cells (ECs). MicroRNAs (miRNAs), which are a group of small non‑coding RNA molecules that post‑transcriptionally regulate the expression of target genes, have been associated with diverse cellular functions and the pathogenesis of various diseases, including atherosclerosis. miRNA-98 (miR‑98) has been demonstrated to be involved in the regulation of cellular apoptosis; however, the role of miR-98 in ox-LDL-induced dysfunction of ECs and atherosclerosis has yet to be elucidated. Therefore, the present study aimed to investigate the role of miR‑98 in ox‑LDL‑induced dysfunction of ECs and the underlying mechanism. It was demonstrated that miR‑98 expression was markedly downregulated in ox‑LDL‑treated human umbilical vein ECs (HUVECs) and that miR-98 promoted the proliferation and alleviated apoptosis of HUVECs exposed to ox‑LDL. In addition, the results demonstrated that lectin‑like oxidized low‑density lipoprotein receptor 1 (LOX‑1) was a direct target of miR‑98 in HUVECs, as indicated by a luciferase assay. The results of the present study suggested that miR‑98 may inhibit the uptake of toxic ox‑LDL, maintain HUVEC proliferation and protect HUVECs against apoptosis via the suppression of LOX-1.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen Z, Wang M, He Q, Li Z, Zhao Y, Wang W, Ma J, Li Y and Chang G: MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1. Exp Ther Med 13: 1702-1710, 2017.
APA
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W. ... Chang, G. (2017). MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1. Experimental and Therapeutic Medicine, 13, 1702-1710. https://doi.org/10.3892/etm.2017.4171
MLA
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W., Ma, J., Li, Y., Chang, G."MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1". Experimental and Therapeutic Medicine 13.5 (2017): 1702-1710.
Chicago
Chen, Z., Wang, M., He, Q., Li, Z., Zhao, Y., Wang, W., Ma, J., Li, Y., Chang, G."MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1702-1710. https://doi.org/10.3892/etm.2017.4171