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Article

Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells

  • Authors:
    • Yan Wang
    • Zunsong Wang
    • Hong Li
    • Wenwei Xu
    • Lin Dong
    • Yan Guo
    • Saran Feng
    • Kehong Bi
    • Chuansheng Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China, Department of Nephrology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 2050-2055
    |
    Published online on: March 6, 2017
       https://doi.org/10.3892/etm.2017.4184
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Abstract

The aim of the present study was to investigate the demethylation effect of arsenic trioxide (As2O3) on the secreted frizzled-related protein 1 (SFRP1) gene and its ability to inhibit the Wingless‑type MMTV integration site family (WNT) pathway in Jurkat cells. Methylation-specific polymerase chain reaction was used to examine the CpG island methylation status of the SFRP1 gene in leukemia cell lines. In addition, the effects on Jurkat cells of treatment with different concentrations of As2O3 for 48 h were investigated. Reverse transcription‑quantitative polymerase chain reaction was employed to measure the expression of mRNAs, while western blot analysis was used to examine protein expression in cells. The SFRP1 gene was methylated in Jurkat cells. However, both methylated and unmethylated SFRP1 genes were detected in HL60 and K562 cells. In normal bone marrow mononuclear cells, the SFRP1 gene was unmethylated. Following treatment with As2O3 for 48 h, the SFRP1 gene was demethylated, and the mRNA and protein expression levels of the SFRP1 gene were increased. By contrast, the mRNA and protein expression levels of β‑catenin and cyclin Dl were downregulated. The protein expression of c‑myc was also downregulated, but As2O3 exhibited no significant effect on the mRNA expression of c‑myc. Abnormal methylation of the SFRP1 gene was detected in Jurkat cells. These results suggest that As2O3 activates SFRP1 gene expression at the mRNA and protein levels in Jurkat cells by demethylation of the SFRP1 gene. Furthermore, they indicate that As2O3 regulates WNT target genes and controls the growth of Jurkat cells through the WNT/β-catenin signaling pathway.
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1 

Xu CB, Shen JZ, Shen SF, Fu HY, Zhu YF and Chen L: The significance of methylation status of secreted frizzled related protein gene promoter in acute leukemia. Zhonghua Nei Ke Za Zhi. 49:769–771. 2010.(In Chinese). PubMed/NCBI

2 

Griffiths EA, Gore SD, Hooker C, McDevitt MA, Karp JE, Smith BD, Mohammad HP, Ye Y, Herman JG and Carraway HE: Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation. Leuk Lyrephoma. 51:1711–1719. 2010. View Article : Google Scholar

3 

Bai XL, Zhang Q, Ye LY, Liang F, Sun X, Chen Y, Hu QD, Fu QH, Su W, Chen Z, et al: Myocyte enhancer factor 2C regulation of hepatocellular carcinoma via vascular endothelial growth factor and Wnt/β-catenin signaling. Oncogene. 34:4089–4097. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Kaveri D, Kastner P, Dembélé D, Nerlov C, Chan S and Kirstetter P: β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL. Blood. 122:694–704. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Shuai X, Zhou D, Shen T, Wu Y, Zhang J, Wang X and Li Q: Overexpression of the novel oncogene SALL4 and activation of the Wnt/beta-catenin pathway in myelodysplastic syndromes. Cancer Genet Cytogenet. 194:119–124. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Valencia A, Román-Gómez J, Cervera J, Such E, Barragán E, Bolufer P, Moscardó F, Sanz GF and Sanz MA: Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists inacute myeloid leukemia. Leukemia. 23:1658–1666. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Román-Gómez J, Cordeu L, Agirre X, Jiménez-Velasco A, San José-Eneriz E, Garate L, Calasanz MJ, Heiniger A, Torres A and Prosper F: Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. Blood. 109:3462–3469. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Ge X and Wang X: Role of Wnt canonical pathway in hematological malignancies. J Hematol Oncol. 3:332010. View Article : Google Scholar : PubMed/NCBI

9 

Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R and Weissman IL: A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 423:409–414. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Weerkamp F, van Dongen JJ and Staal FJ: Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia. Leukemia. 20:1197–1205. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Kawano Y and Kypta R: Secreted antagonists of the Wnt signaling pathway. J Cell Sci. 116:2627–2634. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Wodarz A and Nusse R: Mechanisms of Wnt signaling in development. Ann Rev Cell Dev Biol. 14:59–88. 1998. View Article : Google Scholar

13 

Wang HL, Wang J, Xiao SY, Haydon R, Stoiber D, He TC, Bissonnette M and Hart J: Elevated protein expression of cyclin Di and Fra-I but decreased expression of c-Myc in human colorectal adenoclu'cinomas overexpressing beta-catenin. Int J Cancer. 101:301–310. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Cadigan KM and Liu YI: Wnt signaling: Complexity at the surface. J Cell Sci. 119:395–402. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Pan FY, Zhang SZ, Xu N, Meng FL, Zhang HX, Xue B, Han X and Li CJ: Beta-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription. Histochem Cell Biol. 134:285–295. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, Zhu J, Tang W, Sun GL, Yang KQ, et al: Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood. 89:3354–3360. 1997.PubMed/NCBI

17 

Berenson JR, Matous J, Swift RA, Mapes R, Morrison B and Yeh HS: A phase I/II study of arsenic trioxide/bortezomib/ascorbic acid combination therapy for the treatment of relapsed or refractory multiple myeloma. Clin Cancer Res. 13:1762–1768. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Zhao WL, Chen SJ, Shen Y, Xu L, Cai X, Chen GQ, Shen ZX, Chen Z and Wang ZY: Treatment of acute promyelocytic leukemia with arsenic trioxide: Clinical and basic studies. Leuk Lymphoma. 42:1265–1273. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Tarkanyi I, Dudognon C, Hillion J, Pendino F, Lanotte M, Aradi J and Ségal-Bendirdjian E: Retinoid/arsenic combination therapy of promyelocytic leukemia: Induction of telomerase-dependent cell death. Leukemia. 19:1806–1811. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Du J, Zhou N, Liu H, Jiang F, Wang Y, Hu C, Qi H, Zhong C, Wang X and Li Z: Arsenic induces functional reexpression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer. PloS One. 7:e359572012. View Article : Google Scholar : PubMed/NCBI

21 

Xia J, Li Y, Yang Q, Mei C, Chen Z, Bao B, Ahmad A, Miele L, Sarkar FH and Wang Z: Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 13:9627–9641. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Thomas DJ, Nava GM, Cai SY, Boyer JL, Hernández-Zavala A and Gaskins HR: Arsenic (+ 3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis. Toxicol Sci. 113:70–76. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Ji H, Li Y, Jiang F, Wang X, Zhang J, Shen J and Yang X: Inhibition of transforming growth factor beta/SMAD signal by MiR-155 is involved in arsenic trioxide-induced anti-angiogenesis in prostate cancer. Cancer Sci. 105:1541–1549. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Liu TH, Raval A, Chen SS, Matkovic JJ, Byrd JC and Plass C: CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia. Cancer Res. 66:653–658. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Chim CS, Chan WW, Pang A and Kwong YL: Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: An independent poor prognostic factor. Leukemia. 20:907–909. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Wang Y, Zhu XX and Zhu CS: Abnormal methylation patterns of SFRP1 gene in cells of leukemia and inhibition of arsenic trioxide on the SFRP1 gene. Zhonghua Xue Ye Xue Za Zhi. 34:157–159. 2013.(In Chinese). PubMed/NCBI

27 

Wang Y, Zhu CS, Bi KH, Xu WW, Dong L and Hou M: Study of WIF-1 promoter methylation with expressions of β-catenin in acute leukemia. Zhonghua Yi Xue Za Zhi. 91:2858–2860. 2011.(In Chinese). PubMed/NCBI

28 

Zhu XX, Zhu CS, Wang Y, Xu WW, Dong L, Guo Y, Li H and Bi KH: Analysis of methylation of the Dickkopf1 (DKK-1) gene in acute leukemia. Journal of Shandong University (Health Sciences). 50:84–87. 2012.

29 

Li H, Wang Y, Xu W, Dong L, Guo Y, Bi K and Zhu C: Arsenic trioxide inhibits DNA methyltransferase and restores TMS1 gene expression in K562 cells. Acta Haematol. 133:18–25. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Fu HY, Shen JZ, Wu Y, Shen SF, Zhou HR and Fan LP: Arsenic trioxide inhibits DNA methyltransferase and restores expression of methylation-silenced CDKN2B/CDKN2A genes in human hematologic malignant cells. Oncol Rep. 24:335–343. 2010.PubMed/NCBI

31 

Nusse R and Varmus HE: Wnt genes. Cell. 69:1073–1087. 1992. View Article : Google Scholar : PubMed/NCBI

32 

Shen JZ, Xu CB, Fu HY, Wu DS, Zhou HR and Fan LP: Methylation of secreted frizzled related protein gene in acute leukemia patients in China. Asian Pac J Cancer Prev. 12:2617–2621. 2011.PubMed/NCBI

33 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Meng Z, Wang DM, Li YH, Liu X, Guo SQ and Luo JM: Demethylation effect of inhibitor As2O3 on expression of SHP-1 and C-kit genes in leukemia HL-60 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 21:613–616. 2013.(In Chinese). PubMed/NCBI

35 

Zhang XK, Luo JM and Sun J: Effect of arsenic trioxide and 5-aza-2′-deoxycytidine on SHP-1, JAK3, TYK2 gene expression in K562 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 22:323–328. 2014.(In Chinese). PubMed/NCBI

36 

Cadigan KM: Wnt-beta-catenin signaling. Curr Biol. 18:R943–R947. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Karim R, Tse G, Putti T, Scolyer R and Lee S: The significance of the Wnt pathway in the pathology of human cancers. Pathology. 36:120–128. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Zhang X, Jia S, Yang S and Yang Y, Yang T and Yang Y: Arsenic trioxide induces G2/M arrest in hepatocellular carcinoma cel1s by increasing the tumor suppressor FTEN expression. J Cell Biochem. 113:3528–3535. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Feala JD, Cortes J, Duxbury PM, McCulloch AD, Piermarocchi C and Paternostro G: Statistical properties and robustness of biological controller-target networks. PLoS One. 7:e293742012. View Article : Google Scholar : PubMed/NCBI

40 

Dong X, Ma N, Liu M and Liu Z: Effects of As2O3 nanoparticles on cell growth and apoptosis of NB4 cells. Exp Ther Med. 10:1271–1276. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang Z, Li H, Xu W, Dong L, Guo Y, Feng S, Bi K and Zhu C: Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells. Exp Ther Med 13: 2050-2055, 2017.
APA
Wang, Y., Wang, Z., Li, H., Xu, W., Dong, L., Guo, Y. ... Zhu, C. (2017). Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells. Experimental and Therapeutic Medicine, 13, 2050-2055. https://doi.org/10.3892/etm.2017.4184
MLA
Wang, Y., Wang, Z., Li, H., Xu, W., Dong, L., Guo, Y., Feng, S., Bi, K., Zhu, C."Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells". Experimental and Therapeutic Medicine 13.5 (2017): 2050-2055.
Chicago
Wang, Y., Wang, Z., Li, H., Xu, W., Dong, L., Guo, Y., Feng, S., Bi, K., Zhu, C."Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2050-2055. https://doi.org/10.3892/etm.2017.4184
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang Z, Li H, Xu W, Dong L, Guo Y, Feng S, Bi K and Zhu C: Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells. Exp Ther Med 13: 2050-2055, 2017.
APA
Wang, Y., Wang, Z., Li, H., Xu, W., Dong, L., Guo, Y. ... Zhu, C. (2017). Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells. Experimental and Therapeutic Medicine, 13, 2050-2055. https://doi.org/10.3892/etm.2017.4184
MLA
Wang, Y., Wang, Z., Li, H., Xu, W., Dong, L., Guo, Y., Feng, S., Bi, K., Zhu, C."Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells". Experimental and Therapeutic Medicine 13.5 (2017): 2050-2055.
Chicago
Wang, Y., Wang, Z., Li, H., Xu, W., Dong, L., Guo, Y., Feng, S., Bi, K., Zhu, C."Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2050-2055. https://doi.org/10.3892/etm.2017.4184
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