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Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure

  • Authors:
    • Reinard Iskandar
    • Shengchen Liu
    • Fei Xiang
    • Wen Chen
    • Liangpeng Li
    • Wei Qin
    • Fuhua Huang
    • Xin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China
    Copyright: © Iskandar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1850-1858
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    Published online on: March 8, 2017
       https://doi.org/10.3892/etm.2017.4202
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Abstract

Pericardial fluid, as a biochemical indicator of heart status, directly indicates pathological alteration to the heart. The accumulation of pericardial fluid can be attributed to an underlying systemic or local inflammatory process. However, the pericardial fluid expression of cellular surface markers, as well as several cytokines in chronic heart failure (CHF), remain unclear. In order to evaluate these issues further the pericardial fluid expression of several cytokines and the surface expression of activity markers between CHF patients and non‑heart failure (NHF) patients were analyzed. The pericardial fluid expression of cytokines was measured by immunofluorescence and biomarker of plasma N‑terminal propeptide of B‑type natriuretic peptide (NT‑proBNP), while pericardial fluid levels of soluble glycoprotein 130 (sgp130) were analyzed by ELISA in 50 CHF and 24 NHF patients. In addition, the surface expression of activation markers for T‑cells was measured by immunohistochemistry. Patients with CHF demonstrated increased levels of plasma NT‑proBNP and pericardial fluid sgp130. Surface expression of cellular activation markers CD25 and Foxp3 in the pericardial fluid was increased in patients with CHF. Moreover, the pro‑ and anti‑inflammatory cytokines interferon (IFN)‑γ, interleukin (IL)‑6 and IL‑10 in patients with CHF also demonstrated an increased expression within its pericardial fluid. In addition, there was infiltration of inflammatory cells and enhanced expression of inflammatory cytokines in the pericardial fluid of patients with CHF, which may reflect T cell activation, suggesting that systemic inflammation is important in the progression of CHF. This evidence could indicate a possible novel target for future therapeutics and prevention of CHF.
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Copy and paste a formatted citation
Spandidos Publications style
Iskandar R, Liu S, Xiang F, Chen W, Li L, Qin W, Huang F and Chen X: Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure. Exp Ther Med 13: 1850-1858, 2017.
APA
Iskandar, R., Liu, S., Xiang, F., Chen, W., Li, L., Qin, W. ... Chen, X. (2017). Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure. Experimental and Therapeutic Medicine, 13, 1850-1858. https://doi.org/10.3892/etm.2017.4202
MLA
Iskandar, R., Liu, S., Xiang, F., Chen, W., Li, L., Qin, W., Huang, F., Chen, X."Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure". Experimental and Therapeutic Medicine 13.5 (2017): 1850-1858.
Chicago
Iskandar, R., Liu, S., Xiang, F., Chen, W., Li, L., Qin, W., Huang, F., Chen, X."Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1850-1858. https://doi.org/10.3892/etm.2017.4202
Copy and paste a formatted citation
x
Spandidos Publications style
Iskandar R, Liu S, Xiang F, Chen W, Li L, Qin W, Huang F and Chen X: Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure. Exp Ther Med 13: 1850-1858, 2017.
APA
Iskandar, R., Liu, S., Xiang, F., Chen, W., Li, L., Qin, W. ... Chen, X. (2017). Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure. Experimental and Therapeutic Medicine, 13, 1850-1858. https://doi.org/10.3892/etm.2017.4202
MLA
Iskandar, R., Liu, S., Xiang, F., Chen, W., Li, L., Qin, W., Huang, F., Chen, X."Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure". Experimental and Therapeutic Medicine 13.5 (2017): 1850-1858.
Chicago
Iskandar, R., Liu, S., Xiang, F., Chen, W., Li, L., Qin, W., Huang, F., Chen, X."Expression of pericardial fluid T‑cells and related inflammatory cytokines in patients with chronic heart failure". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1850-1858. https://doi.org/10.3892/etm.2017.4202
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