Open Access

Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report

  • Authors:
    • Chunyu Zhang
    • Xiaoguang Yin
    • Jinghan Zhang
    • Qiang Ao
    • Yongquan Gu
    • Ying Liu
  • View Affiliations

  • Published online on: March 10, 2017     https://doi.org/10.3892/etm.2017.4222
  • Pages: 1922-1926
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Idiopathic pulmonary fibrosis (IPF) is a degenerative disease characterized by fibrosis. Cell therapy has been considered within the therapeutic options for IPF. In this study, we explored the potential benefits of human umbilical cord-derived mesenchymal stem cell (HUC-MSC) intravenous infusion in the management of IPF. We describe a case of a 56-year-old man with IPF who was receiving long-term oxygen therapy (LTOT). The patient underwent HUC-MSC intravenous infusion and was followed up for 12 months. Clinical and motor tests, as well as questionnaires assessing quality of life, were performed prior to and following the transplantation. At the end of 12 months, a relevant reduction of LTOT requirement was registered; improvements in terms of physical performance, quality of life, and respiratory parameters were observed in our patient. In conclusion, a program of HUC-MSC intravenous infusion appears to be beneficial to patients with IPF and may be considered as an additional therapeutic option.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang C, Yin X, Zhang J, Ao Q, Gu Y and Liu Y: Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report. Exp Ther Med 13: 1922-1926, 2017
APA
Zhang, C., Yin, X., Zhang, J., Ao, Q., Gu, Y., & Liu, Y. (2017). Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report. Experimental and Therapeutic Medicine, 13, 1922-1926. https://doi.org/10.3892/etm.2017.4222
MLA
Zhang, C., Yin, X., Zhang, J., Ao, Q., Gu, Y., Liu, Y."Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report". Experimental and Therapeutic Medicine 13.5 (2017): 1922-1926.
Chicago
Zhang, C., Yin, X., Zhang, J., Ao, Q., Gu, Y., Liu, Y."Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1922-1926. https://doi.org/10.3892/etm.2017.4222