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Article Open Access

HOTAIR is a promising novel biomarker in patients with thyroid cancer

  • Authors:
    • Yifei Zhang
    • Sui Yu
    • Lixin Jiang
    • Xixun Wang
    • Xiaojing Song
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Gastrointestinal Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, Shandong 264000, P.R. China, Department of Endocrinology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, Shandong 264000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2274-2278
    |
    Published online on: March 17, 2017
       https://doi.org/10.3892/etm.2017.4231
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Abstract

Thyroid cancer (TC) is the most common endocrine malignancy. Lack of effective early diagnostic tools is one of the clinical obstacles for TC treatment. Thus, enhanced comprehension of the molecular changes in TC tumorigenesis is urgently needed to develop novel strategies for the diagnosis and treatment of TC. Long non‑coding RNAs (lncRNAs) manage fundamental biochemical and cellular processes in tumorigenesis and development. One of the best‑described lncRNAs, HOX transcript antisense RNA (HOTAIR), functions as a regulatory molecule in a wide variety of biological processes, and represses gene expression through recruitment of the chromatin modifying complex. However, the function of HOTAIR in TC remains unclear. In the current study, the expression of HOTAIR is elevated in TC and correlates with metastasis and poor prognosis. Furthermore, the expression of HOTAIR is significantly upregulated in human thyroid carcinoma cells compared with normal human thyroid cells. Furthermore, knockdown of HOTAIR significantly inhibited cell growth and invasion in TPC-1 and SW579 human thyroid carcinoma. In summary, HOTAIR is a promising novel biomarker in patients with TC.
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1 

Fofi C, Festuccia F, Barberi S, Apponi F, Chiacchiararelli L, Scopinaro F, Punzo G and Menè P: Hemodialysis in patients requiring 131I treatment for thyroid carcinoma. Int J Artif Organs. 36:439–443. 2013.PubMed/NCBI

2 

Sherman EJ, Su YB, Lyall A, Schöder H, Fury MG, Ghossein RA, Haque S, Lisa D, Shaha AR, Tuttle RM and Pfister DG: Evaluation of romidepsin for clinical activity and radioactive iodine reuptake in radioactive iodine-refractory thyroid carcinoma. Thyroid. 23:593–599. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Wakabayashi H, Taki J, Inaki A, Toratani A, Kayano D and Kinuya S: Extremity Radioactive Iodine Uptake on Post-therapeutic Whole Body Scan in Patients with Differentiated Thyroid Cancer. Asia Ocean J Nucl Med Biol. 3:26–34. 2015.PubMed/NCBI

4 

Netea-Maier RT, Klück V, Plantinga TS and Smit JW: Autophagy in thyroid cancer: Present knowledge and future perspectives. Front Endocrinol (Lausanne). 6:222015.PubMed/NCBI

5 

Mattick JS: RNA regulation: A new genetics? Nat Rev Genet. 5:316–323. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Morales D Rivea, Thomas K, Presser A, Bernstein BE, van Oudenaarden A, et al: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA. 106:11667–11672. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, Shi Y, Segal E and Chang HY: Long noncoding RNA as modular scaffold of histone modification complexes. Science. 329:689–693. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Huang L, Liao LM, Liu AW, Wu JB, Cheng XL, Lin JX and Zheng M: Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. Arch Gynecol Obstet. 290:717–723. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Zhang JX, Han L, Bao ZS, Wang YY, Chen LY, Yan W, Yu SZ, Pu PY, Liu N, You YP, et al: HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro Oncol. 15:1595–1603. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Thum T and Condorelli G: Long noncoding RNAs and microRNAs in cardiovascular pathophysiology. Circ Res. 116:751–762. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Ling H: Non-coding RNAs: Therapeutic Strategies and Delivery Systems. Adv Exp Med Biol. 937:229–237. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Latronico MV and Condorelli G: Therapeutic applications of noncoding RNAs. Curr Opin Cardiol. 30:213–221. 2015. View Article : Google Scholar : PubMed/NCBI

15 

He D, Wang J, Zhang C, Shan B, Deng X, Li B, Zhou Y, Chen W, Hong J, Gao Y, et al: Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer. Mol Cancer. 14:732015. View Article : Google Scholar : PubMed/NCBI

16 

Hu Y, Xu K and Yagüe E: MiR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer. Breast Cancer Res Treat. 151:269–280. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Rebucci M, Sermeus A, Leonard E, Delaive E, Dieu M, Fransolet M, Arnould T and Michiels C: MiRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1. Mol Cancer. 14:792015. View Article : Google Scholar : PubMed/NCBI

18 

Jin X, Sun Y, Yang H, Li J, Yu S, Chang X, Lu Z and Chen J: Deregulation of the MiR-193b-KRAS axis contributes to impaired cell growth in pancreatic cancer. PloS One. 10:e01255152015. View Article : Google Scholar : PubMed/NCBI

19 

Kohls K, Schmidt D, Holdenrieder S, Müller SC and Ellinger J: Detection of cell-free lncRNA in serum of cancer patients. Urologe A. 54:819–825. 2015.(In German). View Article : Google Scholar : PubMed/NCBI

20 

Li Z, Zhao X, Zhou Y, Liu Y, Zhou Q, Ye H, Wang Y, Zeng J, Song Y, Gao W, et al: The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer. J Transl Med. 13:842015. View Article : Google Scholar : PubMed/NCBI

21 

Yang Q, Xu E, Dai J, Liu B, Han Z, Wu J, Zhang S, Peng B, Zhang Y and Jiang Y: A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol Appl Pharmacol. 285:79–88. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Deng L, Yang SB, Xu FF and Zhang JH: Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge. J Exp Clin Cancer Res. 34:182015. View Article : Google Scholar : PubMed/NCBI

23 

Ishibashi M, Kogo R, Shibata K, Sawada G, Takahashi Y, Kurashige J, Akiyoshi S, Sasaki S, Iwaya T, Sudo T, et al: Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep. 29:946–950. 2013.PubMed/NCBI

24 

Yu X and Li Z: Long non-coding RNA HOTAIR: A novel oncogene (Review). Mol Med Rep. 12:5611–5618. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Yu S, Jiang L, Wang X and Song X: HOTAIR is a promising novel biomarker in patients with thyroid cancer. Exp Ther Med 13: 2274-2278, 2017.
APA
Zhang, Y., Yu, S., Jiang, L., Wang, X., & Song, X. (2017). HOTAIR is a promising novel biomarker in patients with thyroid cancer. Experimental and Therapeutic Medicine, 13, 2274-2278. https://doi.org/10.3892/etm.2017.4231
MLA
Zhang, Y., Yu, S., Jiang, L., Wang, X., Song, X."HOTAIR is a promising novel biomarker in patients with thyroid cancer". Experimental and Therapeutic Medicine 13.5 (2017): 2274-2278.
Chicago
Zhang, Y., Yu, S., Jiang, L., Wang, X., Song, X."HOTAIR is a promising novel biomarker in patients with thyroid cancer". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2274-2278. https://doi.org/10.3892/etm.2017.4231
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Yu S, Jiang L, Wang X and Song X: HOTAIR is a promising novel biomarker in patients with thyroid cancer. Exp Ther Med 13: 2274-2278, 2017.
APA
Zhang, Y., Yu, S., Jiang, L., Wang, X., & Song, X. (2017). HOTAIR is a promising novel biomarker in patients with thyroid cancer. Experimental and Therapeutic Medicine, 13, 2274-2278. https://doi.org/10.3892/etm.2017.4231
MLA
Zhang, Y., Yu, S., Jiang, L., Wang, X., Song, X."HOTAIR is a promising novel biomarker in patients with thyroid cancer". Experimental and Therapeutic Medicine 13.5 (2017): 2274-2278.
Chicago
Zhang, Y., Yu, S., Jiang, L., Wang, X., Song, X."HOTAIR is a promising novel biomarker in patients with thyroid cancer". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2274-2278. https://doi.org/10.3892/etm.2017.4231
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