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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Case Report

Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature

  • Authors:
    • Xiao‑Wei Ma
    • Chang‑Ning Hao
    • Zhi‑Chun Gu
    • Meng Ye
    • Min Li
    • Lan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China, Department of Vascular Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China
  • Pages: 1157-1162
    |
    Published online on: June 14, 2017
       https://doi.org/10.3892/etm.2017.4604
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Abstract

Patients with acute limb ischemia, deep venous thrombosis and pulmonary artery embolism may be treated with warfarin. The dose‑response interaction of warfarin is associated with numerous factors, depending on which an uncommon life‑threatening bleeding may occur. The present case study reported on a patient with acute limb ischemia and a history of warfarin-induced bleeding ten years previously and who again developed life threatening bleeding associated with warfarin treatment and received vascular surgery. In this patient, a cytochrome P450 3A4 loss‑of‑function mutation decreased the effective dose of warfarin. Although this was a rare case, clinicians should be alert to the bleeding risk associated with such rare genetic mutations.
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Copy and paste a formatted citation
Spandidos Publications style
Ma XW, Hao CN, Gu ZC, Ye M, Li M and Zhang L: Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature. Exp Ther Med 14: 1157-1162, 2017.
APA
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., & Zhang, L. (2017). Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature. Experimental and Therapeutic Medicine, 14, 1157-1162. https://doi.org/10.3892/etm.2017.4604
MLA
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., Zhang, L."Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature". Experimental and Therapeutic Medicine 14.2 (2017): 1157-1162.
Chicago
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., Zhang, L."Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1157-1162. https://doi.org/10.3892/etm.2017.4604
Copy and paste a formatted citation
x
Spandidos Publications style
Ma XW, Hao CN, Gu ZC, Ye M, Li M and Zhang L: Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature. Exp Ther Med 14: 1157-1162, 2017.
APA
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., & Zhang, L. (2017). Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature. Experimental and Therapeutic Medicine, 14, 1157-1162. https://doi.org/10.3892/etm.2017.4604
MLA
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., Zhang, L."Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature". Experimental and Therapeutic Medicine 14.2 (2017): 1157-1162.
Chicago
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., Zhang, L."Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1157-1162. https://doi.org/10.3892/etm.2017.4604
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