Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature

  • Authors:
    • Xiao‑Wei Ma
    • Chang‑Ning Hao
    • Zhi‑Chun Gu
    • Meng Ye
    • Min Li
    • Lan Zhang
  • View Affiliations

  • Published online on: June 14, 2017     https://doi.org/10.3892/etm.2017.4604
  • Pages: 1157-1162
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Abstract

Patients with acute limb ischemia, deep venous thrombosis and pulmonary artery embolism may be treated with warfarin. The dose‑response interaction of warfarin is associated with numerous factors, depending on which an uncommon life‑threatening bleeding may occur. The present case study reported on a patient with acute limb ischemia and a history of warfarin-induced bleeding ten years previously and who again developed life threatening bleeding associated with warfarin treatment and received vascular surgery. In this patient, a cytochrome P450 3A4 loss‑of‑function mutation decreased the effective dose of warfarin. Although this was a rare case, clinicians should be alert to the bleeding risk associated with such rare genetic mutations.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ma XW, Hao CN, Gu ZC, Ye M, Li M and Zhang L: Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature. Exp Ther Med 14: 1157-1162, 2017
APA
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., & Zhang, L. (2017). Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature. Experimental and Therapeutic Medicine, 14, 1157-1162. https://doi.org/10.3892/etm.2017.4604
MLA
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., Zhang, L."Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature". Experimental and Therapeutic Medicine 14.2 (2017): 1157-1162.
Chicago
Ma, X., Hao, C., Gu, Z., Ye, M., Li, M., Zhang, L."Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1157-1162. https://doi.org/10.3892/etm.2017.4604