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Article Open Access

Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury

  • Authors:
    • Jian Ding
    • Xin Niu
    • Yan Su
    • Xiaolin Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China, Institute of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1609-1613
    |
    Published online on: June 21, 2017
       https://doi.org/10.3892/etm.2017.4636
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Abstract

In the present study, the levels of synovial fluid biomarkers of patients with knee osteoarthritis (OA) and those with meniscus injury (MI) were compared to associate the levels of synovial fluid biomarkers with the degree of OA and MI. Synovial fluid samples were obtained from 51 cases with OA and 40 patients with MI. Severity of OA and MI were evaluated using the Kellgren-Lawrence (K-L) classification and Magnetic Resonance Imaging Osteoarthritis Knee Score, respectively. A comparative analysis of the levels of matrix metalloproteinase-13 (MMP-13), vascular endothelial growth factor (VEGF), interleukin (IL)-10, IL-8, IL-6, IL-1, tumor necrosis factor-α (TNF-α), as well as collagenase 2 in synovial fluid was made between patients with OA and MI. We found that synovial fluid levels of VEGF and IL-6 were significantly higher in patients with OA than in patients with MI, and IL-10 was lower in patients with OA compared to MI patients (p<0.05). After adjusting for sex, course of disease, and surgical history, no significant associations between K-L scores and biomarker levels were found for patients with OA. In the MI patients, TNF-α was significantly associated with magnetic resonance imaging (MRI) score. In conclusion, patients with knee OA and MI have different patterns of biomarker expression in their synovial fluid.
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Copy and paste a formatted citation
Spandidos Publications style
Ding J, Niu X, Su Y and Li X: Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury. Exp Ther Med 14: 1609-1613, 2017.
APA
Ding, J., Niu, X., Su, Y., & Li, X. (2017). Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury. Experimental and Therapeutic Medicine, 14, 1609-1613. https://doi.org/10.3892/etm.2017.4636
MLA
Ding, J., Niu, X., Su, Y., Li, X."Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury". Experimental and Therapeutic Medicine 14.2 (2017): 1609-1613.
Chicago
Ding, J., Niu, X., Su, Y., Li, X."Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1609-1613. https://doi.org/10.3892/etm.2017.4636
Copy and paste a formatted citation
x
Spandidos Publications style
Ding J, Niu X, Su Y and Li X: Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury. Exp Ther Med 14: 1609-1613, 2017.
APA
Ding, J., Niu, X., Su, Y., & Li, X. (2017). Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury. Experimental and Therapeutic Medicine, 14, 1609-1613. https://doi.org/10.3892/etm.2017.4636
MLA
Ding, J., Niu, X., Su, Y., Li, X."Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury". Experimental and Therapeutic Medicine 14.2 (2017): 1609-1613.
Chicago
Ding, J., Niu, X., Su, Y., Li, X."Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1609-1613. https://doi.org/10.3892/etm.2017.4636
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