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Article

Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa

  • Authors:
    • Yixuan Sun
    • Fengjun Sun
    • Wei Feng
    • Xuewen Qiu
    • Yao Liu
    • Bo Yang
    • Yongchuan Chen
    • Peiyuan Xia
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 1647-1652
    |
    Published online on: June 21, 2017
       https://doi.org/10.3892/etm.2017.4641
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Abstract

Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen in hospital‑acquired infection and is readily able to form biofilms. Due to its high antibiotic resistance, traditional antibacterial treatments exert a limited effect on P. aeruginosa biofilm infections. It has been indicated that hyperoside inhibits P. aeruginosa PAO1 (PAO1) biofilm formation without affecting growth. Therefore, the current study examined the biofilm formation and quorum sensing (QS) system of PAO1 in the presence of hyperoside. Confocal laser scanning microscopy analysis demonstrated that hyperoside significantly inhibited biofilm formation. It was also observed that hyperoside inhibited twitching motility in addition to adhesion. Data from reverse transcription‑quantitative polymerase chain reaction indicated that hyperoside inhibited the expression of lasR, lasI, rhlR and rhlI genes. These results suggest that the QS‑inhibiting effect of hyperoside may lead to a reduction in biofilm formation. However, the precise mechanism of hyperoside on P. aeruginosa pathogenicity remains unclear and requires elucidation in additional studies.
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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Sun F, Feng W, Qiu X, Liu Y, Yang B, Chen Y and Xia P: Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa. Exp Ther Med 14: 1647-1652, 2017.
APA
Sun, Y., Sun, F., Feng, W., Qiu, X., Liu, Y., Yang, B. ... Xia, P. (2017). Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa. Experimental and Therapeutic Medicine, 14, 1647-1652. https://doi.org/10.3892/etm.2017.4641
MLA
Sun, Y., Sun, F., Feng, W., Qiu, X., Liu, Y., Yang, B., Chen, Y., Xia, P."Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa". Experimental and Therapeutic Medicine 14.2 (2017): 1647-1652.
Chicago
Sun, Y., Sun, F., Feng, W., Qiu, X., Liu, Y., Yang, B., Chen, Y., Xia, P."Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1647-1652. https://doi.org/10.3892/etm.2017.4641
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Sun F, Feng W, Qiu X, Liu Y, Yang B, Chen Y and Xia P: Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa. Exp Ther Med 14: 1647-1652, 2017.
APA
Sun, Y., Sun, F., Feng, W., Qiu, X., Liu, Y., Yang, B. ... Xia, P. (2017). Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa. Experimental and Therapeutic Medicine, 14, 1647-1652. https://doi.org/10.3892/etm.2017.4641
MLA
Sun, Y., Sun, F., Feng, W., Qiu, X., Liu, Y., Yang, B., Chen, Y., Xia, P."Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa". Experimental and Therapeutic Medicine 14.2 (2017): 1647-1652.
Chicago
Sun, Y., Sun, F., Feng, W., Qiu, X., Liu, Y., Yang, B., Chen, Y., Xia, P."Hyperoside inhibits biofilm formation of Pseudomonas aeruginosa". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1647-1652. https://doi.org/10.3892/etm.2017.4641
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