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Article

Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors

  • Authors:
    • Jiao‑Jiao Yang
    • Hua Huang
    • Ming‑Bing Xiao
    • Feng Jiang
    • Wen‑Kai Ni
    • Yi‑Fei Ji
    • Cui‑Hua Lu
    • Run‑Zhou Ni
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 1749-1755
    |
    Published online on: June 26, 2017
       https://doi.org/10.3892/etm.2017.4677
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Abstract

Sex comb on midleg like‑2 (SCML2) is a polycomb‑group protein that encodes transcriptional repressors essential for appropriate development in the fly and in mammals. On the basis of previous findings, the present study aimed to explore the possibility of developing SCML2 into a new diagnostic marker for gastroenteropancreatic neuroendocrine tumors (GEP‑NETs). A total of 64 paired GEP‑NET tissues and adjacent non‑tumorous tissues were obtained from patients who had undergone surgical resection between January 2009 and January 2014, and the expression of SCML2 and two neuroendocrine markers, namely synaptophysin (Syn) and chromogranin A (CgA), in the tissues was assessed by immunohistochemistry. Strong SCML2 staining was observed predominantly in the cell nuclei of GEP‑NET tissues, and the overall expression rate and staining intensity of SCML2 were higher than those of Syn or CgA, respectively. Spearman rank correlation analysis demonstrated that SCML2 was not correlated with either Syn or CgA, while the combined detection of SCML2 with Syn or with CgA increased the diagnostic sensitivity to 100%. SCML2 expression in GEP‑NETs was associated with several clinicopathological parameters, such as histological type, tumor grade, depth of invasion and clinical stage. Kaplan‑Meier survival curves revealed that patients with higher SCML2 expression had lower survival rates than those with lower expression levels, while Cox proportional hazards regression analysis revealed that SCML2 was not an independent prognostic factor for GEP‑NET patients. Therefore, SCML2 may have potential as a specific marker for joint use with other markers to improve the diagnostic efficiency of GEP‑NETs.
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Copy and paste a formatted citation
Spandidos Publications style
Yang JJ, Huang H, Xiao MB, Jiang F, Ni WK, Ji YF, Lu CH and Ni RZ: Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors. Exp Ther Med 14: 1749-1755, 2017.
APA
Yang, J., Huang, H., Xiao, M., Jiang, F., Ni, W., Ji, Y. ... Ni, R. (2017). Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors. Experimental and Therapeutic Medicine, 14, 1749-1755. https://doi.org/10.3892/etm.2017.4677
MLA
Yang, J., Huang, H., Xiao, M., Jiang, F., Ni, W., Ji, Y., Lu, C., Ni, R."Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors". Experimental and Therapeutic Medicine 14.2 (2017): 1749-1755.
Chicago
Yang, J., Huang, H., Xiao, M., Jiang, F., Ni, W., Ji, Y., Lu, C., Ni, R."Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1749-1755. https://doi.org/10.3892/etm.2017.4677
Copy and paste a formatted citation
x
Spandidos Publications style
Yang JJ, Huang H, Xiao MB, Jiang F, Ni WK, Ji YF, Lu CH and Ni RZ: Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors. Exp Ther Med 14: 1749-1755, 2017.
APA
Yang, J., Huang, H., Xiao, M., Jiang, F., Ni, W., Ji, Y. ... Ni, R. (2017). Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors. Experimental and Therapeutic Medicine, 14, 1749-1755. https://doi.org/10.3892/etm.2017.4677
MLA
Yang, J., Huang, H., Xiao, M., Jiang, F., Ni, W., Ji, Y., Lu, C., Ni, R."Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors". Experimental and Therapeutic Medicine 14.2 (2017): 1749-1755.
Chicago
Yang, J., Huang, H., Xiao, M., Jiang, F., Ni, W., Ji, Y., Lu, C., Ni, R."Sex comb on midleg like‑2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1749-1755. https://doi.org/10.3892/etm.2017.4677
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