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Article Open Access

Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis

  • Authors:
    • Ai Li
    • Yuan Tao
    • Dexiao Kong
    • Ni Zhang
    • Yongjing Wang
    • Zhilun Wang
    • Yingxue Wang
    • Juandong Wang
    • Juan Xiao
    • Yang Jiang
    • Xiaoli Liu
    • Chengyun Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Cellular Therapy, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1538-1546
    |
    Published online on: June 27, 2017
       https://doi.org/10.3892/etm.2017.4687
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Abstract

The current study evaluated 5 patients with ankylosing spondylitis (AS). Patients received intravenous transfusions of umbilical cord mesenchymal stem cells (uMSCs). All therapeutic and adverse responses were assessed and recorded during uMSC therapy. No severe adverse reactions were observed in any of the patients, although a slight transient fever was observed in 3 patients within 2‑6 h of intravenous administration of uMSCs. Following treatment, the Bath Ankylosing Spondylitis Disease Activity and Bath Ankylosing Spondylitis Metrology Indices decreased, however the Bath Ankylosing Spondylitis Functional Index increased. The erythrocyte sedimentation rate in 3 patients was reduced and C‑reactive protein levels in 1 patient were markedly reduced. The symptoms of AS were alleviated in all patients. The present study indicates that intravenous transfusion of uMSCs is safe and well tolerated by patients and that it effectively alleviates disease activity and clinical symptoms. In the future, a larger cohort of patients with AS should be recruited to enable the systemic evaluation of uMSC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Li A, Tao Y, Kong D, Zhang N, Wang Y, Wang Z, Wang Y, Wang J, Xiao J, Jiang Y, Jiang Y, et al: Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis. Exp Ther Med 14: 1538-1546, 2017.
APA
Li, A., Tao, Y., Kong, D., Zhang, N., Wang, Y., Wang, Z. ... Zheng, C. (2017). Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis. Experimental and Therapeutic Medicine, 14, 1538-1546. https://doi.org/10.3892/etm.2017.4687
MLA
Li, A., Tao, Y., Kong, D., Zhang, N., Wang, Y., Wang, Z., Wang, Y., Wang, J., Xiao, J., Jiang, Y., Liu, X., Zheng, C."Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis". Experimental and Therapeutic Medicine 14.2 (2017): 1538-1546.
Chicago
Li, A., Tao, Y., Kong, D., Zhang, N., Wang, Y., Wang, Z., Wang, Y., Wang, J., Xiao, J., Jiang, Y., Liu, X., Zheng, C."Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1538-1546. https://doi.org/10.3892/etm.2017.4687
Copy and paste a formatted citation
x
Spandidos Publications style
Li A, Tao Y, Kong D, Zhang N, Wang Y, Wang Z, Wang Y, Wang J, Xiao J, Jiang Y, Jiang Y, et al: Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis. Exp Ther Med 14: 1538-1546, 2017.
APA
Li, A., Tao, Y., Kong, D., Zhang, N., Wang, Y., Wang, Z. ... Zheng, C. (2017). Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis. Experimental and Therapeutic Medicine, 14, 1538-1546. https://doi.org/10.3892/etm.2017.4687
MLA
Li, A., Tao, Y., Kong, D., Zhang, N., Wang, Y., Wang, Z., Wang, Y., Wang, J., Xiao, J., Jiang, Y., Liu, X., Zheng, C."Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis". Experimental and Therapeutic Medicine 14.2 (2017): 1538-1546.
Chicago
Li, A., Tao, Y., Kong, D., Zhang, N., Wang, Y., Wang, Z., Wang, Y., Wang, J., Xiao, J., Jiang, Y., Liu, X., Zheng, C."Infusion of umbilical cord mesenchymal stem cells alleviates symptoms of ankylosing spondylitis". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1538-1546. https://doi.org/10.3892/etm.2017.4687
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