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Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants

  • Authors:
    • Jing Ma
    • Ruan Biao
    • Fan Lou
    • Ken Lin
    • Ying‑Qin Gao
    • Mei‑Lan Wang
    • Yan‑Li Yang
    • Tie‑Song Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China, Department of Otolaryngology, The First Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1293-1298
    |
    Published online on: June 28, 2017
       https://doi.org/10.3892/etm.2017.4703
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Abstract

The treatment of lymphatic malformations (LMs) represents a great clinical challenge. The present study reported on the treatment of 68 infants with cervical macrocystic LMs using surgical resection. The cases were retrospectively analyzed. All patients underwent pre‑operative ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) examinations. The surgery was performed under general anesthesia with endotracheal intubation. Ultrasonograms showed that 24 cases were monolocular, 44 were multilocular, 16 had no echo, 20 had a uniform low‑level echo and 32 had a non‑uniform low‑level echo. CT showed non‑enhancing low‑attenuating cystic lesions and attenuation values of 10‑45 HU. The magnetic resonance images of the LMs showed a low signal intensity on T1‑weighted imaging (WI) and a high signal intensity on T2‑WI. Complete resection was achieved in 56 patients, subtotal resection in eight and partial resection in four. Two complications were noted, including reversible paresis of the marginal mandibular branch of the facial nerve and a surgical‑site infection. One patient in whom partial resection was achieved had recurrence at ~2 months after the surgery. Ultrasonography, CT and MRI clearly demonstrated the size, shape, extent and adjacent structures of LMs, which aided in surgical planning and assessment of potential risks. Surgical excision increased the chances of cure and was relatively safe for infants aged <1 year. Location and extent, rather than age, were determined to be the most important factors for successful surgical treatment.
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1 

Mulliken JB, Burrows PE and Fishman SJ: Mulliken and Young's vascular anomalies: Hemangiomas and malformations. Oxford: Oxford University Press; 2013, View Article : Google Scholar

2 

Cho BC, Kim JB, Lee JW, Choi KY, Yang JD, Lee SJ, Kim YS, Lee JM, Huh S and Chung HY: Cervicofacial lymphatic malformations: A retrospective review of 40 cases. Arch Plast Surg. 43:10–18. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Vlahovic A, Gazikalovic A and Adjic O: Bleomycin sclerotherapy for lymphatic malformation after unsuccessful surgical excision: Case report. Acta Otorhinolaryngol Ital. 35:365–367. 2015.PubMed/NCBI

4 

Wiegand S and Werner JA: Lymphatic malformations in the head and neck area. HNO. 64:133–142. 2016.(In German). View Article : Google Scholar : PubMed/NCBI

5 

Werner JA, Dünne AA, Folz BJ, Rochels R, Bien S, Ramaswamy A and Lippert BM: Current concepts in the classification, diagnosis and treatment of hemangiomas and vascular malformations of the head and neck. Eur Arch Otorhinolaryngol. 258:141–149. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Farnoosh S, Don D, Koempel J, Panossian A, Anselmo D and Stanley P: Efficacy of doxycycline and sodium tetradecyl sulfate sclerotherapy in pediatric head and neck lymphatic malformations. Int J Pediatr Otorhinolaryngol. 79:883–887. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Yang Y, Sun M, Ma Q, Cheng X, Ao J, Tian L, Wang L and Lei D: Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 53:150–155. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ameh EA, Caouette-Laberge L and Laberge JM: Lymphangiomas. Ameh EA, Bickler SW, Lakhoo K, Nwomeh BC and Poenaru D: Paediatric surgery: A comprehensive text for Africa. GLOBAL HELP Organization Seattle. 649–654. 2011.

9 

Ates LE, Kapran Y, Erbil Y, Barbaros U and Dizdaroglu F: Cystic lymphangioma of the right adrenal gland. Pathol Oncol Res. 11:242–244. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Zadvinskis DP, Benson MT, Kerr HH, Mancuso AA, Cacciarelli AA, Madrazo BL, Mafee MF and Dalen K: Congenital malformations of the cervicothoracic lymphatic system: Embryology and pathogenesis. Radiographics. 12:1175–1189. 1992. View Article : Google Scholar : PubMed/NCBI

11 

Zakaria RH, Barsoum NR, El-Basmy AA and El-Kaffas SH: Imaging of pericardial lymphangioma. Ann Pediatr Cardiol. 4:65–67. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Chaabouni A, Rebai N, Fourati M, Rekik S, Chabchoub K, Slimen MH, Bahloul A and Mhiri MN: Cystic lymphangioma of the kidney: Diagnosis and management. Int J Surg Case Rep. 3:587–589. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Fung K, Poenaru D, Soboleski DA and Kamal IM: Impact of magnetic resonance imaging on the surgical management of cystic hygromas. J Pediatr Surg. 33:839–841. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Balakrishnan K, Menezes MD, Chen BS, Magit AE and Perkins JA: Primary surgery vs primary sclerotherapy for head and neck lymphaticmal formations. JAMA Otolaryngol Head Neck Surg. 140:41–45. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Okazaki T, Iwatani S, Yanai T, Kobayashi H, Kato Y, Marusasa T, Lane GJ and Yamataka A: Treatment of lymphangioma in children: Our experience of 128 cases. J Pediatr Surg. 42:386–389. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Balakrishnan A and Bailey CM: Lymphangioma of the tongue: A review of pathogenesis, treatment and the use of surface laser photocoagulation. J Laryngol Otol. 105:924–930. 1991. View Article : Google Scholar : PubMed/NCBI

17 

Swetman GL, Berk DR, Vasanawala SS, Feinstein JA, Lane AT and Bruckner AL: Sildenafil for severe lymphatic malformations. N Engl J Med. 366:384–386. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Boardman SJ, Cochrane LA, Roebuck D, Elliott MJ and Hartley BE: Multimodality treatment of pediatric lymphatic malformations of the head and neck using surgery and sclerotherapy. Arch Otolaryngol Head Neck Surg. 136:270–276. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Chen WL, Zhang B, Wang JG, Ye HS, Zhang DM and Huang ZQ: Surgical excision of cervicofacial giant macrocystic lymphatic malformations in infants and children. Int J Pediatr Otorhinolaryngol. 73:833–837. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Perkins JA, Maniglia C, Magit A, Sidhu M, Manning SC and Chen EY: Clinical and radiographic findings in children with spontaneous lymphatic malformation regression. Otolaryngol Head Neck Surg. 138:772–777. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Kennedy TL, Whitaker M, Pellitteri P and Wood WE: Cystic hygroma/lymphangioma: A rational approach to management. Laryngoscope. 111:1929–1937. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Kumar V, Kumar P, Pandey A, Gupta DK, Shukla RC, Sharma SP and Gangopadhyay AN: Intralesional bleomycin in lymphangioma: An effective and safe non-operative modality of treatment. J Cutan Aesthet Surg. 5:133–136. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Biao R, Lou F, Lin K, Gao YQ, Wang ML, Yang YL and Zhang TS: Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants. Exp Ther Med 14: 1293-1298, 2017.
APA
Ma, J., Biao, R., Lou, F., Lin, K., Gao, Y., Wang, M. ... Zhang, T. (2017). Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants. Experimental and Therapeutic Medicine, 14, 1293-1298. https://doi.org/10.3892/etm.2017.4703
MLA
Ma, J., Biao, R., Lou, F., Lin, K., Gao, Y., Wang, M., Yang, Y., Zhang, T."Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants". Experimental and Therapeutic Medicine 14.2 (2017): 1293-1298.
Chicago
Ma, J., Biao, R., Lou, F., Lin, K., Gao, Y., Wang, M., Yang, Y., Zhang, T."Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1293-1298. https://doi.org/10.3892/etm.2017.4703
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Biao R, Lou F, Lin K, Gao YQ, Wang ML, Yang YL and Zhang TS: Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants. Exp Ther Med 14: 1293-1298, 2017.
APA
Ma, J., Biao, R., Lou, F., Lin, K., Gao, Y., Wang, M. ... Zhang, T. (2017). Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants. Experimental and Therapeutic Medicine, 14, 1293-1298. https://doi.org/10.3892/etm.2017.4703
MLA
Ma, J., Biao, R., Lou, F., Lin, K., Gao, Y., Wang, M., Yang, Y., Zhang, T."Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants". Experimental and Therapeutic Medicine 14.2 (2017): 1293-1298.
Chicago
Ma, J., Biao, R., Lou, F., Lin, K., Gao, Y., Wang, M., Yang, Y., Zhang, T."Diagnosis and surgical treatment of cervical macrocystic lymphatic malformations in infants". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1293-1298. https://doi.org/10.3892/etm.2017.4703
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