Analgesic activity of cynaropicrinon on post‑inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model

  • Authors:
    • Hailong Shi
    • Xianwei Zhu
    • Yaya Cui
    • Yifei Qin
    • Lin Yang
    • Xu Deng
  • View Affiliations

  • Published online on: August 25, 2017     https://doi.org/10.3892/etm.2017.5037
  • Pages: 4476-4482
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Visceral hypersensitivity is one of the most common symptoms in patients with post-inflammatory‑irritable bowel syndrome (PI‑IBS). Enterochromaffin (EC) cells and 5‑hydroxytryptamine (5‑HT) are important in the development of visceral hyperalgesia, and EC cells are influenced by helper T‑cell subtype 1 or 2 cytokine predominant environments. In the present study, the analgesic effect of cynaropicrin and its underlying mechanism on the treatment of trinitrobenzene sulfonic (TNBS)‑induced PI‑IBS visceral hyperalgesia rats was investigated. The results from the abdominal withdrawal reflex tests and electromyography recordings indicated that treatment with cynaropicrin significantly and dose‑dependently alleviated the visceral hyperalgesia of PI‑IBS rats (P<0.05). In addition, the increased colonic 5‑HT content, colonic tryptophan hydroxylase expression, EC cell number and the cytokine levels, including tumor necrosis factor‑α and interleukin‑6 in PI‑IBS rats were significantly alleviated by cynaropicrin (P<0.05). These data demonstrate that the analgesic activity of cynaropicrin on TNBS‑induced PI‑IBS visceral hypersensitive rats was mediated via reduction of cytokines levels. Thus, cynaropicrin as a bioactive natural product may offer promising therapeutic avenues for visceral hypersensitivity in IBS.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shi H, Zhu X, Cui Y, Qin Y, Yang L and Deng X: Analgesic activity of cynaropicrinon on post‑inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model. Exp Ther Med 14: 4476-4482, 2017
APA
Shi, H., Zhu, X., Cui, Y., Qin, Y., Yang, L., & Deng, X. (2017). Analgesic activity of cynaropicrinon on post‑inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model. Experimental and Therapeutic Medicine, 14, 4476-4482. https://doi.org/10.3892/etm.2017.5037
MLA
Shi, H., Zhu, X., Cui, Y., Qin, Y., Yang, L., Deng, X."Analgesic activity of cynaropicrinon on post‑inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model". Experimental and Therapeutic Medicine 14.5 (2017): 4476-4482.
Chicago
Shi, H., Zhu, X., Cui, Y., Qin, Y., Yang, L., Deng, X."Analgesic activity of cynaropicrinon on post‑inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4476-4482. https://doi.org/10.3892/etm.2017.5037