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Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats

  • Authors:
    • Xiahong Tang
    • Feng Chen
    • Qinming Lin
    • Yan You
    • Jun Ke
    • Shen Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350009, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4312-4320
    |
    Published online on: August 28, 2017
       https://doi.org/10.3892/etm.2017.5059
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Abstract

The present study aimed to investigate the beneficial effects and underlying mechanisms of bone marrow mesenchymal stem cells (BMSCs) on global ischemic hypoxic brain injury. Cells collected from the femurs and tibias of male Sprague Dawley rats were used to generate BMSCs following three culture passages. A rate model of cardiac arrest (CA) was induced by asphyxia. One hour following return of spontaneous circulation (ROSC), BMSCs were transplanted through injection into the tail vein. Neurological status was assessed using modified neurological severity score (mNSS) tests 1, 3 and 7 days following ROSC. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and immunohistochemical staining were used to detect insulin‑like growth factor 1 (IGF‑1) expression in the hippocampus. Furthermore, double‑fluorescent labeling of green fluorescent protein (GFP) and IGF‑1 was used to detect the IGF‑1 expression in transplanted BMSCs. Serum levels of protein S100‑B were examined using ELISA. GFP‑labeled BMSCs were observed in the hippocampus at 1, 3 and 7 days post transplantation through fluorescent microscopy. BMSC transplantation resulted in reduced protein S100‑B levels. The mNSS of the BMSC‑treatment group was significantly reduced compared with that of the CA group. The RT‑qPCR analysis and immunohistochemistry results demonstrated that BMSC treatment significantly increased IGF‑1 expression in the hippocampus. In addition, the double‑fluorescent labeling results demonstrated that transplanted BMSCs expressed IGF‑1 in the hippocampus. The results of the present study suggest that BMSC treatment promotes the recovery of cerebral function following CA in rats possibly through the secretion of IGF‑1.
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View References

1 

Writing Group Members, . Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, et al: Heart Disease and Stroke Statistics-2016 Update A Report From the American Heart Association. Circulation. 133:E38–E360. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Popp E, Vogel P, Teschendorf P and Böttiger BW: Effects of the application of erythropoietin on cerebral recovery after cardiac arrest in rats. Resuscitation. 74:344–351. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Callaway CW, Donnino MW, Fink EL, Geocadin RG, Golan E, Kern KB, Leary M, Meurer WJ, Peberdy MA, Thompson TM and Zimmerman JL: Part 8: Post-cardiac arrest care: 2015 American heart association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular car. Circulation. 132 18 Suppl 2:S465–S482. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Teschendorf P, Vogel P, Wippel A, Krumnikl JJ, Spöhr F, Böttiger BW and Popp E: The effect of intracerebroventricular application of the caspase-3 inhibitor zDEVD-FMK on neurological outcome and neuronal cell death after global cerebral ischaemia due to cardiac arrest in rats. Resuscitation. 78:85–91. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Mohal JS, Tailor HD and Khan WS: Sources of adult mesenchymal stem cells and their applicability for musculoskeletal applications. Curr Stem Cell Res Ther. 7:103–109. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Colter DC, Class R, DiGirolamo CM and Prockop DJ: Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci USA. 97:3213–3218. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Chen A, Siow B, Blamire AM, Lako M and Clowry GJ: Transplantation of magnetically labeled mesenchymal stem cells in a model of perinatal brain injury. Stem Cell Res. 5:255–266. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Ding X, Li Y, Liu Z, Zhang J, Cui Y, Chen X and Chopp M: The sonic hedgehog pathway mediates brain plasticity and subsequent functional recovery after bone marrow stromal cell treatment of stroke in mice. J Cereb Blood Flow Metab. 33:1015–1024. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Kim SJ, Moon GJ, Chang WH, Kim YH and Bang OY: STARTING-2 (STem cell Application Researches and Trials In NeuroloGy-2) collaborators: Intravenous transplantation of mesenchymal stem cells preconditioned with early phase stroke serum: Current evidence and study protocol for a randomized trial. Trials. 14:3172013. View Article : Google Scholar : PubMed/NCBI

10 

Chen JL, Li Y, Wang L, Lu M, Zhang XH and Chopp M: Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci. 189:49–57. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Wakabayashi K, Nagai A, Sheikh AM, Shiota Y, Narantuya D, Watanabe T, Masuda J, Kobayashi S, Kim SU and Yamaguchi S: Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J Neurosci Res. 88:1017–1025. 2010.PubMed/NCBI

12 

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, et al: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41–49. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Dvorakova J, Hruba A, Velebny V and Kubala L: Isolation and characterization of mesenchymal stem cell population entrapped in bone marrow collection sets. Cell Biol Int. 32:1116–1125. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K and Hori S: H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc. 1:e0034592012. View Article : Google Scholar : PubMed/NCBI

15 

Xu K, Puchowicz MA, Lust WD and LaManna JC: Adenosine treatment delays postischemic hippocampal CA1 loss after cardiac arrest and resuscitation in rats. Brain Res. 1071:208–217. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Shen LH, Li Y, Chen J, Zhang J, Vanguri P, Borneman J and Chopp M: Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience. 137:393–399. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Lebouvier A, Poignard A, Cavet M, Amiaud J, Leotot J, Hernigou P, Rahmouni A, Bierling P, Layrolle P, Rouard H and Chevallier N: Development of a simple procedure for the treatment of femoral head osteonecrosis with intra-osseous injection of bone marrow mesenchymal stromal cells: Study of their biodistribution in the early time points after injection. Stem Cell Res Ther. 6:682015. View Article : Google Scholar : PubMed/NCBI

19 

Zheng W, Honmou O, Miyata K, Harada K, Suzuki J, Liu H, Houkin K, Hamada H and Kocsis JD: Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. Brain Res. 1310:8–16. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Ohtaki H, Ylostalo JH, Foraker JE, Robinson AP, Reger RL, Shioda S and Prockop DJ: Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proc Natl Acad Sci USA. 105:14638–14643. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Yiu G and He Z: Glial inhibition of CNS axon regeneration. Nat Rev Neurosci. 7:617–627. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Huber AB, Weinmann O, Brösamle C, Oertle T and Schwab ME: Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions. J Neurosci. 22:3553–3567. 2002.PubMed/NCBI

23 

Shen LH, Li Y, Chen J, Cui Y, Zhang C, Kapke A, Lu M, Savant-Bhonsale S and Chopp M: One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke. 38:2150–2156. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Shichinohe H, Ishihara T, Takahashi K, Tanaka Y, Miyamoto M, Yamauchi T, Saito H, Takemoto H, Houkin K and Kuroda S: Bone marrow stromal cells rescue ischemic brain by trophic effects and phenotypic change toward neural cells. Neurorehabil Neural Repair. 29:80–89. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Nakano N, Nakai Y, Seo TB, Yamada Y, Ohno T, Yamanaka A, Nagai Y, Fukushima M, Suzuki Y, Nakatani T and Ide C: Characterization of conditioned medium of cultured bone marrow stromal cells. Neurosci Lett. 483:57–61. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Skoff RP, Bessert D, Barks JD and Silverstein FS: Plasticity of neurons and glia following neonatal hypoxic-ischemic brain injury in rats. Neurochem Res. 32:331–342. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Wang X, Deng J, Boyle DW, Zhong J and Lee WH: Potential Role of IGF-I in hypoxia tolerance using a rat hypoxic-ischemic model: Activation of hypoxia-inducible factor 1alpha. Pediatr Res. 55:385–394. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, et al: The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 69:893–905. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Šerbedžija P, Madl JE and Ishii DN: Insulin and IGF-I prevent brain atrophy and DNA loss in diabetes. Brain Res. 1303:179–194. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Landi S, Ciucci F, Maffei L, Berardi N and Cenni MC: Setting the pace for retinal development: Environmental enrichment acts through insulin-like growth factor 1 and brain-derived neurotrophic factor. J Neurosci. 29:10809–10819. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Lopez-Lopez C, LeRoith D and Torres-Aleman I: Insulin-like growth factor I is required for vessel remodeling in the adult brain. Proc Natl Acad Sci USA. 101:9833–9838. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Guan J: Insulin-like growth factor-1 (IGF-1) derived neuropeptides, a novel strategy for the development of pharmaceuticals for managing ischemic brain injury. CNS Neurosci Ther. 17:250–255. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC and Kahn CR: Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol. 22:965–977. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Khokhlatchev AV, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E and Cobb MH: Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell. 93:605–615. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Peruzzi F, Prisco M, Dews M, Salomoni P, Grassilli E, Romano G, Calabretta B and Baserga R: Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis. Mol Cell Biol. 19:7203–7215. 1999. View Article : Google Scholar : PubMed/NCBI

36 

Scheid MP and Duronio V: Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation. Proc Natl Acad Sci USA. 95:7439–7444. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Tanaka R, Miyasaka Y, Yada K, Ohwada T and Kameya T: Basic fibroblast growth factor increases regional cerebral blood flow and reduces infarct size after experimental ischemia in a rat model. Stroke. 26:2154–2159. 1995. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang X, Chen F, Lin Q, You Y, Ke J and Zhao S: Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats. Exp Ther Med 14: 4312-4320, 2017.
APA
Tang, X., Chen, F., Lin, Q., You, Y., Ke, J., & Zhao, S. (2017). Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats. Experimental and Therapeutic Medicine, 14, 4312-4320. https://doi.org/10.3892/etm.2017.5059
MLA
Tang, X., Chen, F., Lin, Q., You, Y., Ke, J., Zhao, S."Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats". Experimental and Therapeutic Medicine 14.5 (2017): 4312-4320.
Chicago
Tang, X., Chen, F., Lin, Q., You, Y., Ke, J., Zhao, S."Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4312-4320. https://doi.org/10.3892/etm.2017.5059
Copy and paste a formatted citation
x
Spandidos Publications style
Tang X, Chen F, Lin Q, You Y, Ke J and Zhao S: Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats. Exp Ther Med 14: 4312-4320, 2017.
APA
Tang, X., Chen, F., Lin, Q., You, Y., Ke, J., & Zhao, S. (2017). Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats. Experimental and Therapeutic Medicine, 14, 4312-4320. https://doi.org/10.3892/etm.2017.5059
MLA
Tang, X., Chen, F., Lin, Q., You, Y., Ke, J., Zhao, S."Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats". Experimental and Therapeutic Medicine 14.5 (2017): 4312-4320.
Chicago
Tang, X., Chen, F., Lin, Q., You, Y., Ke, J., Zhao, S."Bone marrow mesenchymal stem cells repair the hippocampal neurons and increase the expression of IGF‑1 after cardiac arrest in rats". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4312-4320. https://doi.org/10.3892/etm.2017.5059
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