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The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels

  • Authors:
    • Hao Zhou
    • Nuan Wang
    • Lei Xu
    • Hongli Huang
    • Chunyu Yu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China, Department of Pharmacy, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4801-4806
    |
    Published online on: September 14, 2017
       https://doi.org/10.3892/etm.2017.5116
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Abstract

This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin‑B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high‑mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. The clinical data of 92 EAS patients admitted for treatment between April, 2014 and March, 2016 were collected. These patients were randomly divided into control and observation groups (n=46 each) using computer software. Patients in the control group were administered only regular antiepileptic drugs, whereas observation group patients also received a combination of gastrodin, FOL and V-B12. After treatment, we compared efficacy, frequency of epileptic seizure, and Montreal cognitive assessment (MoCA) scores. Serum homocysteine (HCY), FOL and V-B12 levels were detected 3 months later. Enzyme‑linked immunosorbent assay (ELISA) was used to detect changes in serum HMGB-1, IL-2 and IL-6 levels at one day before treatment and on the 7th, 21st, 30th and 90th days after treatment. Pearson's correlation coefficient was utilized to analyze the correlations of HMGB-1 with IL-2 and IL-6. The total treatment effectiveness rate was 95.65% in the observation group, which was significantly higher than the control group (73.91%, p<0.05). Epileptic seizure frequency and MoCA scores significantly improved in the observation group (p<0.05). Serum HCY levels were significantly lower, whereas FOL and V-B12 serum levels were significantly higher, at 3 months post-treatment start in the observation group relative to control group (p<0.05). After treatment, serum HMGB-1, IL-2 and IL-6 levels progressively decreased over time in both groups, but observation group levels were significantly lower than in control group (p<0.05). Pearson's correlation coefficient analysis showed that HMGB-1 levels were positively correlated with IL-2 and IL-6 levels. A combination of gastrodin, FOL and V-B12 for EAS can significantly improve inflammatory response symptoms, decrease HCY levels, and increase FOL and V-B12 levels in serum while effectively controlling epileptic seizures, thus exhibiting relatively better clinical efficacy. Therefore, this combination treatment is worthy of being promoted in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Wang N, Xu L, Huang H and Yu C: The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. Exp Ther Med 14: 4801-4806, 2017.
APA
Zhou, H., Wang, N., Xu, L., Huang, H., & Yu, C. (2017). The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. Experimental and Therapeutic Medicine, 14, 4801-4806. https://doi.org/10.3892/etm.2017.5116
MLA
Zhou, H., Wang, N., Xu, L., Huang, H., Yu, C."The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels". Experimental and Therapeutic Medicine 14.5 (2017): 4801-4806.
Chicago
Zhou, H., Wang, N., Xu, L., Huang, H., Yu, C."The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4801-4806. https://doi.org/10.3892/etm.2017.5116
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Wang N, Xu L, Huang H and Yu C: The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. Exp Ther Med 14: 4801-4806, 2017.
APA
Zhou, H., Wang, N., Xu, L., Huang, H., & Yu, C. (2017). The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels. Experimental and Therapeutic Medicine, 14, 4801-4806. https://doi.org/10.3892/etm.2017.5116
MLA
Zhou, H., Wang, N., Xu, L., Huang, H., Yu, C."The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels". Experimental and Therapeutic Medicine 14.5 (2017): 4801-4806.
Chicago
Zhou, H., Wang, N., Xu, L., Huang, H., Yu, C."The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4801-4806. https://doi.org/10.3892/etm.2017.5116
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