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Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis

  • Authors:
    • Yiming Li
    • Xiangjun Cai
    • Bo Chen
    • Hanbo Gu
    • Caigang Liu
  • View Affiliations / Copyright

    Affiliations: Division of Breast Surgery, Department of Surgical Oncology, General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of General Surgery, 202 Hospital of People's Liberation Army, Shenyang, Liaoning 110812, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4862-4868
    |
    Published online on: September 19, 2017
       https://doi.org/10.3892/etm.2017.5132
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Abstract

Epithelial cell transforming 2 (Ect2) protein is a member of the human diffuse B‑cell lymphoma family of guanine nucleotide exchange factors, which activate the Ras homolog gene family of small GTPases; however, the clinical implications of Ect2 in colorectal carcinoma (CRC) are unclear. The present study aimed to determine the relationship between Ect2 expression and prognosis in patients with CRC. Western blot analysis and immunohistochemistry assays were used to determine the expression of Ect2 in CRC and paired non‑cancerous tissues from 66 patients. The correlation between Ect2 expression and clinicopathological parameters was assessed using χ2 tests. Patient survival was determined using the Kaplan‑Meier method and log‑rank test. Cox regression was used for multivariate analysis of prognostic factors. Results demonstrated that Ect2 protein was highly expressed in human CRC samples [29/45 (64.45%)] and significantly correlated with a poor prognosis (P<0.05). Compared with normal tissues, CRC tissues demonstrated higher expression levels of Ect2 mRNA [44/66 (66.67%)]. In addition, highly‑expressed Ect2 was significantly associated with recurrence (P=0.023) and invasion (P=0.008) of CRC. High Ect2 expression levels in patients were associated with poorer overall survival (OS) and disease‑free survival (DFS) compared with lower expression levels of Ect2. Based on multivariate analysis, Ect2 overexpression was significantly correlated with OS and DFS (P=0.015 and 0.020, respectively). In conclusion, Ect2 overexpression is an independent and important prognostic factor for OS and DFS in patients with CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Cai X, Chen B, Gu H and Liu C: Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis. Exp Ther Med 14: 4862-4868, 2017.
APA
Li, Y., Cai, X., Chen, B., Gu, H., & Liu, C. (2017). Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis. Experimental and Therapeutic Medicine, 14, 4862-4868. https://doi.org/10.3892/etm.2017.5132
MLA
Li, Y., Cai, X., Chen, B., Gu, H., Liu, C."Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis". Experimental and Therapeutic Medicine 14.5 (2017): 4862-4868.
Chicago
Li, Y., Cai, X., Chen, B., Gu, H., Liu, C."Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4862-4868. https://doi.org/10.3892/etm.2017.5132
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Cai X, Chen B, Gu H and Liu C: Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis. Exp Ther Med 14: 4862-4868, 2017.
APA
Li, Y., Cai, X., Chen, B., Gu, H., & Liu, C. (2017). Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis. Experimental and Therapeutic Medicine, 14, 4862-4868. https://doi.org/10.3892/etm.2017.5132
MLA
Li, Y., Cai, X., Chen, B., Gu, H., Liu, C."Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis". Experimental and Therapeutic Medicine 14.5 (2017): 4862-4868.
Chicago
Li, Y., Cai, X., Chen, B., Gu, H., Liu, C."Overexpression of epithelial cell transforming 2 protein in colorectal carcinoma predicts a poor prognosis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4862-4868. https://doi.org/10.3892/etm.2017.5132
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